Navigation Links
Simple online tool to aid GPs in early ovarian cancer diagnosis
Date:1/4/2012

The lives of hundreds of women could be saved every year, thanks to a simple online calculator that could help GPs identify women most at risk of having ovarian cancer at a much earlier stage.

Academics from The University of Nottingham and ClinRisk Ltd have developed a new QCancer algorithm using the UK QResearch database. The new algorithm assesses a combination of patients' symptoms and risk factors to red flag those most likely to have ovarian cancer and enable them to be referred for further investigation or treatment at a much earlier stage.

A study into the effectiveness of the algorithm, published online this week at BMJ.com, has shown that it was successful in predicting almost two-thirds of ovarian cancers in the 10 per cent of women who were most at risk of having the disease over a two year period.

Leading the research, Professor Julia Hippisley-Cox, said: "Ovarian cancer is notoriously difficult to spot and we hope that this new tool will help GPs identify patients most at risk of having ovarian cancer for early referral and investigations."

Ovarian cancer is the seventh most common cancer in women worldwide and affects around 6,700 women in the UK every year, one of the highest rates in Europe. Most women are diagnosed when the disease is already at an advanced stage, meaning that in many cases their chances of surviving for five years after diagnosis can be as low as six per cent.

Less than one-third of women are diagnosed in the first stages of the disease but of those 90 per cent will survive to five years, showing that earlier diagnosis and treatment can have a dramatic impact on the patient's chances of survival.

However, GPs are faced with the tough challenge of making a correct diagnosis as early as possible for a disease which has few established risk factors and a range of non-specific symptoms such as loss of appetite, weight loss and abdominal pain which could also point to a number of less serious and more common conditions.

For the study, the academics used anonymous data from 564 GPs surgeries using the QResearch database system a not-for-profit partnership between The University of Nottingham and leading GPs systems supplier EMIS.

They included information for female patients aged 30 to 84 who had not previously been diagnosed with ovarian cancer and did not have one of a number of 'red flag' symptoms in the previous 12 months.

They assessed risk factors including age, family history, previous diagnosis of other forms of cancer, loss of appetite, weight loss, abdominal distension, rectal bleeding, postmenopausal bleeding and anaemia to predict which patients were most at risk of having ovarian cancer and combined these in the risk prediction algorithm.

The tool was successful in predicting 63 per cent of all ovarian cancers over the following two years which were in the top 10 per cent of women found to be most at risk.

In addition to detecting cancer at an earlier stage, the tool could help GPs to direct their scarce resources such as ultrasonography, MRI scans and blood tests, to the patients more urgently in need of further investigation.

It is in line with current Government policy and the National Awareness and Early Diagnosis Initiative (NAEDI) a public/third sector partnership between the Department of Health, National Cancer Action Team and Cancer Research UK.

The simple web-based calculator http://www.qcancer.org/ovary is designed for doctors but a simpler version could also be made available on the internet to raise awareness among the general public and to prompt women with risk factors or symptoms to seek advice from their doctor. It could also be integrated into GP clinical computer systems for use during the consultation or for identifying patients with combinations of symptoms needing further assessment.

Similar scores using QResearch have already proven effective in previous research in identifying patients at most risk of developing lung cancer, gastro-oesophageal cancer, bowel cancer, pancreatic cancer, heart disease, type 2 diabetes, fractures, kidney disease and serious blood clots.

Professor Hippisley-Cox added: "We are very grateful for the continuing support of the EMIS GP practices that contribute their high quality data to QResearch. Without them, our research would not be possible."


'/>"/>
Contact: Emma Thorne
emma.thorne@nottingham.ac.uk
44-011-595-15793
University of Nottingham
Source:Eurekalert

Related medicine news :

1. Simple test to help diagnose bowel and pancreatic cancer could save thousands of lives
2. Simple blood test diagnoses Parkinsons disease long before symptoms appear
3. Radiologists: Going green with small, simple step
4. Simple lifestyle changes can add a decade or more healthy years to the average lifespan
5. Food Nutrition Labels Must Be Made Simpler, Experts Say
6. Simple MRIs Safe for Children, Study Says
7. Cancer Patients Should Ask Doctors to Use Simple Terms
8. Simple Safety Steps Can Make Back to School a Breeze
9. A new set of building blocks for simple synthesis of complex molecules
10. Simple guidelines decreased unnecessary antibiotic use in Quebec, Canada
11. Understanding Numbers Isnt as Simple as 1, 2, 3
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... ... February 24, 2017 , ... The narrative in “ ... Erik Schanssema ’s true account of his paramedic experiences. Schanssema describes the tragedies he ... and his attempts to overcome them. , Schanssema, initially unsure of the career path ...
(Date:2/24/2017)... ... 2017 , ... The International Association of Eating Disorders Professionals (iaedp) announces the ... body image mannequin art competition. Selected from 15 submissions from around the nation, the ... the 31st annual iaedp Symposium, March 22 – 26 in Las Vegas. , This ...
(Date:2/24/2017)... ... February 24, 2017 , ... Congratulations to Head Over ... on February 12th. Ms. Esparza qualified into this prestigious status after winning ... in Las Vegas, Nevada. Frida is one of approximately 25 gymnasts in the ...
(Date:2/23/2017)... ... 23, 2017 , ... The 89th Academy Awards will be celebrated this weekend, ... Policy Center Bunkum Award. We invite you to enjoy our 11th annual tongue-in-cheek “salute” ... is the Center for American Progress (CAP), for its report, Lessons From State Performance ...
(Date:2/23/2017)... ... February 23, 2017 , ... Los Angeles-based weight loss ... WE TV’s “Mama June: From Not to Hot,” which will begin airing on February ... Shannon, known to millions from the 2012 reality television series, “Here Comes Honey Boo ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... Feb. 23, 2017  Genesis Healthcare Services has merged ... was made by Bill Monast , President and ... and Nathan Feltman , executives with Home Health ... LLC. This acquisition helps Hospice Cloud ... technology enabled durable medical equipment (DME) solutions for the ...
(Date:2/23/2017)... 23, 2017 ITL Limited, ( ASX: ITD ), an ... the half year ended 31 December 2016 compared with the previous ... can be viewed here . Highlights ... up 104%) Earnings per share of 2.2 cents ... $17.5m (Dec 2015: $15.7m; up 11%) Profit before ...
(Date:2/23/2017)... GUIYANG, China , 23. Februar 2017 ... Area , eine nationale Wirtschaftszone in der südwestlichen chinesischen Provinz ... Beschleunigung der Errichtung einer Innovationsplattform aktiv an der Entwicklung einer ... Continue Reading ... ...
Breaking Medicine Technology: