Navigation Links
Simple gene test identifies clinically important subtypes of breast cancer
Date:5/6/2010

Brussels, 6 May 2010 -- A simple genetic test that uses just three genes is among the most effective means of classifying breast cancer into sub-types, US researchers report at the IMPAKT Breast Cancer Conference in Brussels, Belgium. The findings are a significant step in bringing more personalized treatment into breast cancer.

The study is based on the already well-established fact that breast cancer is not one biologically homogeneous disease, but it is composed of several molecular sub-types each of which is characterized by distinct gene expression profiles.

"It is these differences that explain, at least in part, why patients who have tumors that appear to be similar may experience completely different clinical outcomes such as prognosis and response to anticancer therapies," said Dr Benjamin Haibe-Kains from Dana-Farber Cancer Institute in Boston, USA. "Thus, there is an urgent need for developing a robust tool to provide clinicians with guidance for classifying breast cancer molecular sub-types, which could then aid in making therapeutic decisions."

Several research groups have already developed a range of different genetic 'fingerprints' they use to assign breast cancers into different sub-types, but questions have been raised about the reliability of these groupings.

To shed new light on this issue, Dr Haibe-Kains and colleagues performed the largest comparative study to date of breast cancer sub-types, analyzing 32 publicly available gene expression datasets including more than 4600 breast cancer patients and six different classification models.

"We studied these models in terms of concordance and prognostic value and, for the first time, we estimated their robustness: that is, their capacity to assign the same tumors to the same molecular sub-types whatever the gene expression data used to fit this model."

Two main classes of classification models have been published during the last decade: the Single Sample Predictor (SSP) and the Sub-type Classification Model (SCM). Over the years the list of genes used by these models have been refined, leading to the publication of six distinct classification models.

"Generally speaking, we found that SCMs yielded stronger concordance than SSPs," Dr Haibe-Kains said. "We also observed that SCMs, including a simple model that uses only three genes --ESR1, ERBB2 and AURKA-- were significantly more robust than SSPs."

By demonstrating the robustness of the SCM models, the new study is a significant step towards bringing these classification models into the clinic, Dr Haibe-Kains said. "The robustness of SCMs makes them promising candidates for an implementation into the clinic especially in the simplest form --that is, a model using only three genes."


'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Related medicine news :

1. Dr. Keith Berman's Beach Body Secrets: 7 Simple Tips for Weight Loss Success
2. Simple reduction technique decreases radiation dose associated with CT scans of the head
3. Simple Carbs Pose Heart Risk for Women
4. A Simple Thank You Brings Rewards to All
5. Simple Memory Test May Detect Early Alzheimers
6. Simple Test May Spot Early Lung Cancer
7. The Simple and Revolutionary Power to OUTSMART YOUR GENES Out April 6th -- Predictive Medicine Pioneer Dr. Brandon Colby Releases Book
8. Simple Forms Help Docs Do Better Breast Exams
9. Many With Arthritis Find Simple Solutions for Relief
10. NationalCreditReport.com Offers Simple Tax Saving Tips That Can Improve Credit Scores
11. UAB-led study shows simple steps could reduce stillbirths by up to 1 million
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... MA (PRWEB) , ... May 25, 2016 , ... ... Research Institute (WCRI) compare outcomes of injured workers across 15 states. The ... to work, earnings recovery, access to medical care, and satisfaction with medical care. ...
(Date:5/25/2016)... ... , ... CloudLIMS, joins an elite number of companies that have earned a ... 2016 by CIOReview. , In a deliberate session with the honorary industrial experts, a ... been concluded with. The positioning is based on evaluation of CloudLIMS’ specialties in Automated ...
(Date:5/25/2016)... ... May 25, 2016 , ... The ... Drug Development through Molecular Imaging.” The focus of ADDMI-IG will be geared towards ... and development pipeline issues. Through ADDMI-IG WMIS will provide a platform for productive ...
(Date:5/25/2016)... ... May 25, 2016 , ... ... products in the developing world, is pleased to release their 2015 global impact ... million unwanted pregnancies, almost 14,000 maternal deaths and 3.8 million unsafe abortions across ...
(Date:5/25/2016)... ... May 25, 2016 , ... Afrimesure specializes in ... and pharmaceutical, to food and HVAC facilities. Their knowledgeable staff also takes care ... For medical applications, Afrimesure offers a variety of MadgeTech systems available for sterilization ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... May 25, 2016 Digital Health Dialog, ... it by the US Patent and Trademark Office ... includes proprietary processes for electronic opt-­in and processing ... wellness programs, HIPAA compliance and otherwise. ... "Our technology allows for individuals ...
(Date:5/24/2016)... 2016 Cirujanos holandeses han puesto ... los médicos a compartir sus mejores prácticas por el ... Profesionales médicos de Europa, África, Asia ... la aplicación, que combina la transmisión en vivo con ... Educación   "Imagine un médico de ...
(Date:5/24/2016)... 24, 2016  NxStage Medical, Inc. (Nasdaq: ... advancing renal care, today announced that Jeffrey H. ... the following schedule of investor conferences. Where applicable, a ... http://ir.nxstage.com/ .   ... NY, NY           Friday, June 10, 2016 1:30 p.m. ...
Breaking Medicine Technology: