Navigation Links
Simple gene test identifies clinically important subtypes of breast cancer

Brussels, 6 May 2010 -- A simple genetic test that uses just three genes is among the most effective means of classifying breast cancer into sub-types, US researchers report at the IMPAKT Breast Cancer Conference in Brussels, Belgium. The findings are a significant step in bringing more personalized treatment into breast cancer.

The study is based on the already well-established fact that breast cancer is not one biologically homogeneous disease, but it is composed of several molecular sub-types each of which is characterized by distinct gene expression profiles.

"It is these differences that explain, at least in part, why patients who have tumors that appear to be similar may experience completely different clinical outcomes such as prognosis and response to anticancer therapies," said Dr Benjamin Haibe-Kains from Dana-Farber Cancer Institute in Boston, USA. "Thus, there is an urgent need for developing a robust tool to provide clinicians with guidance for classifying breast cancer molecular sub-types, which could then aid in making therapeutic decisions."

Several research groups have already developed a range of different genetic 'fingerprints' they use to assign breast cancers into different sub-types, but questions have been raised about the reliability of these groupings.

To shed new light on this issue, Dr Haibe-Kains and colleagues performed the largest comparative study to date of breast cancer sub-types, analyzing 32 publicly available gene expression datasets including more than 4600 breast cancer patients and six different classification models.

"We studied these models in terms of concordance and prognostic value and, for the first time, we estimated their robustness: that is, their capacity to assign the same tumors to the same molecular sub-types whatever the gene expression data used to fit this model."

Two main classes of classification models have been published during the last decade: the Single Sample Predictor (SSP) and the Sub-type Classification Model (SCM). Over the years the list of genes used by these models have been refined, leading to the publication of six distinct classification models.

"Generally speaking, we found that SCMs yielded stronger concordance than SSPs," Dr Haibe-Kains said. "We also observed that SCMs, including a simple model that uses only three genes --ESR1, ERBB2 and AURKA-- were significantly more robust than SSPs."

By demonstrating the robustness of the SCM models, the new study is a significant step towards bringing these classification models into the clinic, Dr Haibe-Kains said. "The robustness of SCMs makes them promising candidates for an implementation into the clinic especially in the simplest form --that is, a model using only three genes."


Contact: Vanessa Pavinato
European Society for Medical Oncology

Related medicine news :

1. Dr. Keith Berman's Beach Body Secrets: 7 Simple Tips for Weight Loss Success
2. Simple reduction technique decreases radiation dose associated with CT scans of the head
3. Simple Carbs Pose Heart Risk for Women
4. A Simple Thank You Brings Rewards to All
5. Simple Memory Test May Detect Early Alzheimers
6. Simple Test May Spot Early Lung Cancer
7. The Simple and Revolutionary Power to OUTSMART YOUR GENES Out April 6th -- Predictive Medicine Pioneer Dr. Brandon Colby Releases Book
8. Simple Forms Help Docs Do Better Breast Exams
9. Many With Arthritis Find Simple Solutions for Relief
10. Offers Simple Tax Saving Tips That Can Improve Credit Scores
11. UAB-led study shows simple steps could reduce stillbirths by up to 1 million
Post Your Comments:
(Date:12/1/2015)... ... December 01, 2015 , ... Lutronic, a leading innovator ... the latest addition to the devices for sale in the United States. Clarity ... and long-pulsed 1064 nm Nd:YAG lasers, into a single platform that is easy to ...
(Date:12/1/2015)... CA (PRWEB) , ... December 01, 2015 , ... ... has selected 10 semi-finalists to head to Las Vegas for CES 2016, the world’s ... including CEO of Consumer Technology Association Gary Shapiro, Founding Partner of Pacific Investments Veronica ...
(Date:12/1/2015)... ... 2015 , ... Nurotron Biotechnology Co., Ltd., maker of cochlear implant systems, has ... The order will be from the China Disabled Persons’ Federation, a central government association, ... solution for children and adults suffering from severe and profound hearing loss . ...
(Date:12/1/2015)... ... December 01, 2015 , ... Tympani Inc., announced ... (ATP) status from Cisco. This designation recognizes Tympani as having fulfilled the training ... solutions targeted to the high-end enterprise contact center marketplace. , Ed Kapelinski, President ...
(Date:11/30/2015)... , ... November 30, 2015 , ... Trevor and Taylor ... as they play for the chance to represent the United States. This hybrid ... to be a part of their journey in addition to offering corporate sponsors with ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... UPPSALA, Sverige, December 1, 2015 ... Breast Cancer Study Group (IBCSG, Bern ... att ingå i en klinisk studie av palbociclib, ... --> Studien, med namn PYTHIA, ... med anti-hormonella läkemedel i kombination med palbociclib, som ...
(Date:11/30/2015)... MAPLE GROVE, Minn. and BASEL, ... Upsher-Smith Laboratories, Inc. (Upsher-Smith), through its wholly-owned ... for the further development of a novel, oral small ... cell-adhesion molecule that may be effective in the treatment ... Phase II clinical development. --> ...
(Date:11/30/2015)... Dec. 1, 2015 Express Scripts (NASDAQ: ESRX ... IMMY ) to drive access to a low-cost alternative ... of toxoplasmosis that has been recently priced out of reach ... immune systems. --> --> ... leucovorin (a form of folic acid) for $1 per capsule for ...
Breaking Medicine Technology: