Navigation Links
Simple gene test identifies clinically important subtypes of breast cancer
Date:5/6/2010

Brussels, 6 May 2010 -- A simple genetic test that uses just three genes is among the most effective means of classifying breast cancer into sub-types, US researchers report at the IMPAKT Breast Cancer Conference in Brussels, Belgium. The findings are a significant step in bringing more personalized treatment into breast cancer.

The study is based on the already well-established fact that breast cancer is not one biologically homogeneous disease, but it is composed of several molecular sub-types each of which is characterized by distinct gene expression profiles.

"It is these differences that explain, at least in part, why patients who have tumors that appear to be similar may experience completely different clinical outcomes such as prognosis and response to anticancer therapies," said Dr Benjamin Haibe-Kains from Dana-Farber Cancer Institute in Boston, USA. "Thus, there is an urgent need for developing a robust tool to provide clinicians with guidance for classifying breast cancer molecular sub-types, which could then aid in making therapeutic decisions."

Several research groups have already developed a range of different genetic 'fingerprints' they use to assign breast cancers into different sub-types, but questions have been raised about the reliability of these groupings.

To shed new light on this issue, Dr Haibe-Kains and colleagues performed the largest comparative study to date of breast cancer sub-types, analyzing 32 publicly available gene expression datasets including more than 4600 breast cancer patients and six different classification models.

"We studied these models in terms of concordance and prognostic value and, for the first time, we estimated their robustness: that is, their capacity to assign the same tumors to the same molecular sub-types whatever the gene expression data used to fit this model."

Two main classes of classification models have been published during the last decade: t
'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Dr. Keith Berman's Beach Body Secrets: 7 Simple Tips for Weight Loss Success
2. Simple reduction technique decreases radiation dose associated with CT scans of the head
3. Simple Carbs Pose Heart Risk for Women
4. A Simple Thank You Brings Rewards to All
5. Simple Memory Test May Detect Early Alzheimers
6. Simple Test May Spot Early Lung Cancer
7. The Simple and Revolutionary Power to OUTSMART YOUR GENES Out April 6th -- Predictive Medicine Pioneer Dr. Brandon Colby Releases Book
8. Simple Forms Help Docs Do Better Breast Exams
9. Many With Arthritis Find Simple Solutions for Relief
10. NationalCreditReport.com Offers Simple Tax Saving Tips That Can Improve Credit Scores
11. UAB-led study shows simple steps could reduce stillbirths by up to 1 million
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Recently, Weddingshe.com has added many trendy Champagne wedding ... revenues in the past three years. Today, the business announces ... According to the sales manager of the company, this is ... 2015. This point can be reflected on the discounted wedding ...
(Date:1/22/2015)... Boulder, Colorado (PRWEB) January 22, 2015 Four years ... is Queen – which coincided with the marriage of Avasa & ... album, THE ROAD, which is scheduled for release through White Swan ... heartfelt message that there is a sacred path available to all ...
(Date:1/22/2015)... Mass. (PRWEB) January 22, 2015 EBSCO ... (AMA) are expanding their relationship in an effort to ... around the world. While EBSCO has long made AMA journals ... a sales agent for The JAMA Network. , ...
(Date:1/22/2015)... a famous dress online store for wedding dresses and other ... of wedding dresses , and launches a site-wide women’s dress ... on your big day; the wedding gown is the most ... find the most suitable wedding dress. Now, we are proud ...
(Date:1/22/2015)... 2015 Lower-Auto-Insurance.com has released a new blog post ... car for reducing the costs of an auto insurance policy ... able to get lower prices for their vehicle insurance policies. The ... in determining policy costs. Because of this, drivers should always ...
Breaking Medicine News(10 mins):Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2Health News:Driving Safe And Other Factors That Make Auto Insurance Affordable! 2
... ,New evidence shows that an "electronic nose" containing ... to identify asthma in patients. Researchers from Italy compared ... function tests and fraction of exhaled nitric oxide (FENO) ... For each person, the electronic nose analysis was performed ...
... the University of Wisconsin-Madison, one of the most ... screen high-risk pregnant patients for rare but very ... collaboration with The Medical College of Wisconsin, Milwaukee; ... Hospital, Chicago, the ultrasensitive detector measures magnetic signals ...
... study finds , MONDAY, April 5 (HealthDay News) -- ... teen girls is cost-effective, U.S. researchers report. , A ... to a 45 percent reduction in repeated births within ... , This new study, published in the April issue ...
... from injuries is increasing for Americans ages 65 and ... Hopkins Bloomberg School of Public Health,s Center for Injury ... death rates from falls (42 percent increase), machinery (46 ... poisoning (34 percent increase). The results are published in ...
... ... courses, which begin mid-April and during the spring, are part of the curricula of ... programs. More individual courses will be offered in the months to come. , ... Laurel, MD (Vocus) April 5, 2010 ...
... media and others interested in the chemical sciences are invited ... Society (ACS) Webinars, Your Career Matters! featuring speakers ... and engineering professionals. Scheduled for Thursday, April 8, 2 ... Susan Butts, Senior Director of External Science & Technology ...
Cached Medicine News:Health News:News briefs from the April issue of Chest 2Health News:Ultrasensitive detector pinpoints big problem in tiny fetal heart 2Health News:Ultrasensitive detector pinpoints big problem in tiny fetal heart 3Health News:Ultrasensitive detector pinpoints big problem in tiny fetal heart 4Health News:Cost-Effective Program Helps Prevent Repeat Teen Births 2Health News:Fatal injuries increase in older Americans 2Health News:Tai Sophia Institute Offers Individual Graduate-Level Courses 2Health News:Tai Sophia Institute Offers Individual Graduate-Level Courses 3Health News:Tai Sophia Institute Offers Individual Graduate-Level Courses 4Health News:ACS Webinar features tips for finding and building a career in public policy and chemical industry 2
(Date:1/22/2015)... , Jan. 22, 2015  ViewRay™, a privately held ... into an exclusive distributor agreement with ITOCHU Corporation (Tokyo ... therapy system for the treatment of cancer in ... system, is the world,s first and only MRI-guided radiation ...
(Date:1/22/2015)... ON , Jan. 22, 2015 /PRNewswire/ - Pivotal Therapeutics Inc. ... with a focus on Omega-3 therapies for cardiovascular disease and ... of the Company,s accomplishments in 2014 and its outlook for ... Dear Fellow Shareholders, We would like to ...
(Date:1/22/2015)... PARK, Calif. , Jan. 22, 2015 Increasing ... the continued consolidation of localization purchasing in 2015, says ... According to a recent study by market research ... chose a single-source solution for their translation and localization ...
Breaking Medicine Technology:ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7Moravia Sees Single-Sourcing as Key Localization Trend in 2015 2
The Mitek Restore System, designed in conjunction with Sanford S. Kunkel, M.D., offers instrumentation for all ACL Procedures....
The cordless Simon Dermatome with rechargeable battery is used to harvest split-thickness skin grafts and for debridement....
... quality and innovation has resulted in one ... Model C is an air dermatome especially ... in burn care surgery. The Model C ... same dedication to quality, durability and reliability ...
Needle holder, delicate, curved without lock...
Medicine Products: