Navigation Links
Simple blood test may predict if a child will become obese
Date:3/27/2014

Researchers at the Universities of Southampton, Plymouth and Exeter used the test to assess the levels of epigenetic switches in the PGC1a gene a gene that regulates fat storage in the body.

Epigenetic switches take place through a chemical change called DNA methylation, which controls how genes work and is set during early life.

The Southampton team found that the test, when carried out on children at five years old, differentiates between children with a high body fat and those with a low body fat when they were older. Results showed that a rise in DNA methylation levels of 10 per cent at five years was associated with up to 12 per cent more body fat at 14 years. Results were independent of the child's gender, their amount of physical activity and their timing of puberty.

Dr Graham Burdge, of the University of Southampton who led the study with colleague Dr Karen Lillycrop, comments: "It can be difficult to predict when children are very young, which children will put on weight or become obese. It is important to know which children are at risk because help, such as suggestions about their diet, can be offered early and before they start to gain weight.

"The results of our study provide further evidence that being overweight or obese in childhood is not just due to lifestyle, but may also involve important basic processes that control our genes. We hope that this knowledge will help us to develop and test new ways to prevent children developing obesity which can be introduced before a child starts to gain excess weight. However, our findings now need to be tested in larger groups of children."

The study, which also involved Professor Terence Wilkin at the University of Exeter and Dr Joanne Hosking at Plymouth University, is published in the journal Diabetes. The researchers used DNA samples from 40 children who took part in the EarlyBird project, which studied 300 children in Plymouth from the age of five until they were 14 years old.

Led by Professor Wilkin, the study assessed the children in Plymouth each year for factors related to type 2 diabetes, such as the amount of exercise they undertook and the amount of fat in their body. A blood sample was collected and stored. The Southampton team extracted DNA from these blood samples to test for epigenetic switches.

Joanne Hosking, research fellow at Plymouth University, says: "This a unique longitudinal data set and we hope to gain even further insight by looking at what happens in these children beyond age 14 years and into adulthood."

Professor Wilkin says: "The EarlyBird study has already provided important information about the causes of obesity in children. Now samples stored during the study have provided clues about the role of fundamental processes that affect how genes work, over which a child has no control. This has shown that these mechanisms can affect their health during childhood and as adults."


'/>"/>

Contact: Andrew Gould
andrew.gould@plymouth.ac.uk
University of Plymouth
Source:Eurekalert

Related medicine news :

1. Simple assault and ground level fall do not require cervical spine CT
2. Prosthetic retina offers simple solution to restoring sight
3. Cancer may require simpler genetic mutations than previously thought
4. Safe, simple eye test may help save lives by preventing stroke
5. Simple new way to clean traces of impurities from drug ingredients
6. Simpler lifestyle found to reduce exposure to endocrine-disrupting chemicals
7. Simple exercises are an easy and cost-effective treatment for persistent dizziness
8. Simple Steps Can Shield Children From Dog Bites
9. Simple Measures May Curb Excessive Weight Gain in Pregnancy
10. Simple mathematical computations underlie brain circuits
11. Simple new test to combat counterfeit drug problem in developing countries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/26/2017)... ... February 26, 2017 , ... NuevaCare, a leading home care agency based ... and Palo Alto, is proud to announce an important upgrade to its geographic information ... home care close to home, and by having city-specific pages, NuevaCare is answering that ...
(Date:2/26/2017)... ... February 26, 2017 , ... ... staffing, scheduling, and reporting for healthcare organizations. This comprehensive and customizable solution ... staffing process. StaffBridge technology improves staffing efficiency, maximizes resource allocation, collects critical ...
(Date:2/26/2017)... ... February 26, 2017 , ... Occupational pesticide exposure is ... specific LRRK2 mutation, according to a study released today at the 1st Pan ... a link between pesticides and incidence of sporadic PD through occupational exposure. This ...
(Date:2/24/2017)... ... February 24, 2017 , ... ... tooth replacement options at his office, Antoine Dental Center. Currently, patients can get ... Some restrictions may apply, but patients can learn more about these offers by ...
(Date:2/24/2017)... ... 24, 2017 , ... An in-depth computational analysis of genetic variants implicated in ... eight genes that may explain why susceptibility to one of the disorders could place ... published today in the journal npj Schizophrenia. , “There is a wealth of ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... Period October – December 2016 ... to SEK -16.4 (-6.4) million Result after tax amounted to ... after dilution Cash flow from operating activities amounted to SEK ... Period full ... Operating result amounted to SEK -39.5 (-29.5) million ...
(Date:2/24/2017)... Mass. , Feb. 24, 2017  Today, ... US dental labs have a new path to ... using the Biodenta implant library integrated into exocad ... must implement FDA compliant Good Manufacturing Processes (GMP,s) ... manufacturer with Biodenta, and complete an audit process. Then, ...
(Date:2/24/2017)... Research and Markets has announced the addition ... Industry Forecast to 2025" report to their offering. ... The Global Wireless Health ... over the next decade to reach approximately $330.5 billion by 2025. ... for all the given segments on global as well as regional ...
Breaking Medicine Technology: