Navigation Links
Simple Test May Identify Breast Cancer Subtypes
Date:5/7/2010

These classifications can help explain different outcomes for women with similar-looking tumors, expert says

FRIDAY, May 7 (HealthDay News) -- Classification of breast cancer into subtypes can be achieved through a simple genetic test that uses only three genes, U.S. researchers say.

They analyzed 32 gene expression data sets, including more than 4,600 breast cancer patients and six classification models.

"We studied these models in terms of concordance and prognostic value and, for the first time, we estimated their robustness: that is, their capacity to assign the same tumors to the same molecular subtypes whatever the gene expression data used to fit this model," Dr. Benjamin Haibe-Kains, of the Dana-Farber Cancer Institute in Boston, said in a news release from the European Society for Medical Oncology.

A simple test that uses three genes -- ESR1, ERBB2 and AURKA -- was found to be highly effective in identifying breast cancer subtypes.

The study was to be presented Thursday at the IMPAKT Breast Cancer Conference in Brussels, Belgium.

It's long been known that breast cancer isn't one biologically identical disease, but includes several molecular subtypes that have distinct gene expression profiles.

"It is these differences that explain, at least in part, why patients who have tumors that appear to be similar may experience completely different clinical outcomes such as prognosis and response to anticancer therapies," Haibe-Kains said in the news release. "Thus, there is an urgent need for developing a robust tool to provide clinicians with guidance for classifying breast cancer molecular subtypes, which could then aid in making therapeutic decisions."

More information

The American Cancer Society has more about breast cancer.



-- Robert Preidt



SOURCE: European Society for Medical Oncology, news release, May 6, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. SimpleWebBox Offers Free Websites for Non-Profit Organizations
2. Monkey Brain Hardwired for Simple Math
3. Shamy & Shamy Launches New Web Site Providing Simple Access to Free Online Resources for New Jersey Court System
4. Father Channels His Grief into Advocacy, Promotes Simple Actions to Make Hospitals Safer for Children
5. Simple Concussion Test Measures Reaction Time
6. UAB-led study shows simple steps could reduce stillbirths by up to 1 million
7. NationalCreditReport.com Offers Simple Tax Saving Tips That Can Improve Credit Scores
8. Many With Arthritis Find Simple Solutions for Relief
9. Simple Forms Help Docs Do Better Breast Exams
10. The Simple and Revolutionary Power to OUTSMART YOUR GENES Out April 6th -- Predictive Medicine Pioneer Dr. Brandon Colby Releases Book
11. Simple Test May Spot Early Lung Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2017)... ... September 20, 2017 , ... Doctors on Liens has added the medical group ... professionals working on a personal injury lien basis. Founded by Dr. Wayne Cheng, MD ... doctors’ vast experience with orthopedic injuries to patients in the Inland Empire. , Bones ...
(Date:9/20/2017)... ... September 20, 2017 , ... As part of The ... unveiled a redesigned website. The new site – still located at http://www.garlandco.com ... contractors and other industry users that Garland serves. , After an ambitious phase ...
(Date:9/20/2017)... ... September 20, 2017 , ... Five consumer packaged goods (CPG) products were selected ... different categories. Nopavera Plus was named to the short list in the ... West 2017 during presentations at SupplySide Central on Sept. 27 and 28 at Mandalay ...
(Date:9/20/2017)... ... ... “The Trials I Face to Receive God’s Grace”: a mesmerizing take on one ... better one’s life through God. “The Trials I Face to Receive God’s Grace” is ... found a love for writing. Green feels that expressing his feelings through prayer will ...
(Date:9/20/2017)... ... ... “Psalms of Humidity”: is a fascinating depiction of daily struggles and the inspirational ... to God. “Psalms of Humidity” is the creation of published author, David Waldrop, an ... life are the very same things that have shaped him into the man that ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... , Sept. 6, 2017 NeuroRx, a clinical ... Suicidal Ideation and Behavior (ASIB), has been granted Fast Track ... sequential therapy of NRX-100 (ketamine HCl) followed by NRX-101 (D-cycloserine ... a pivotal trial of this sequential therapy targeting patients who ... 1 ...
(Date:9/5/2017)... 5, 2017  Just 18 months after its February ... to announce the appointment of three new senior people ... Dominic Jones-Phillips and James Wright ... Tammy Wynne joins ... access writers. She has over ten years, experience in ...
(Date:8/31/2017)... NEW YORK , Aug. 31, 2017 ... the industry,s must-read guide to the latest innovations happening ... the first industry publication to focus on providing a ... advancements. Ultimately, the issue covers the most innovative companies, ... year. "Everyone in ...
Breaking Medicine Technology: