Navigation Links
Simple Test May Identify Breast Cancer Subtypes

These classifications can help explain different outcomes for women with similar-looking tumors, expert says

FRIDAY, May 7 (HealthDay News) -- Classification of breast cancer into subtypes can be achieved through a simple genetic test that uses only three genes, U.S. researchers say.

They analyzed 32 gene expression data sets, including more than 4,600 breast cancer patients and six classification models.

"We studied these models in terms of concordance and prognostic value and, for the first time, we estimated their robustness: that is, their capacity to assign the same tumors to the same molecular subtypes whatever the gene expression data used to fit this model," Dr. Benjamin Haibe-Kains, of the Dana-Farber Cancer Institute in Boston, said in a news release from the European Society for Medical Oncology.

A simple test that uses three genes -- ESR1, ERBB2 and AURKA -- was found to be highly effective in identifying breast cancer subtypes.

The study was to be presented Thursday at the IMPAKT Breast Cancer Conference in Brussels, Belgium.

It's long been known that breast cancer isn't one biologically identical disease, but includes several molecular subtypes that have distinct gene expression profiles.

"It is these differences that explain, at least in part, why patients who have tumors that appear to be similar may experience completely different clinical outcomes such as prognosis and response to anticancer therapies," Haibe-Kains said in the news release. "Thus, there is an urgent need for developing a robust tool to provide clinicians with guidance for classifying breast cancer molecular subtypes, which could then aid in making therapeutic decisions."

More information

The American Cancer Society has more about breast cancer.

-- Robert Preidt

SOURCE: European Society for Medical Oncology, news release, May 6, 2010

Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. SimpleWebBox Offers Free Websites for Non-Profit Organizations
2. Monkey Brain Hardwired for Simple Math
3. Shamy & Shamy Launches New Web Site Providing Simple Access to Free Online Resources for New Jersey Court System
4. Father Channels His Grief into Advocacy, Promotes Simple Actions to Make Hospitals Safer for Children
5. Simple Concussion Test Measures Reaction Time
6. UAB-led study shows simple steps could reduce stillbirths by up to 1 million
7. Offers Simple Tax Saving Tips That Can Improve Credit Scores
8. Many With Arthritis Find Simple Solutions for Relief
9. Simple Forms Help Docs Do Better Breast Exams
10. The Simple and Revolutionary Power to OUTSMART YOUR GENES Out April 6th -- Predictive Medicine Pioneer Dr. Brandon Colby Releases Book
11. Simple Test May Spot Early Lung Cancer
Post Your Comments:
(Date:11/27/2015)... ... , ... A simply groundbreaking television series, "Voices in America", which is hosted ... array of issues that are presently affecting Americans. Dedicated to providing the world with ... changing the subjects consumers focus on, one episode at a time. , In ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... successful and prominent nonprofit healthcare organizations in the country. They have overseen financial ... organizations, and helped advance the healthcare industry as a whole through their advocacy ...
(Date:11/26/2015)... ... November 26, 2015 , ... Patients at Serenity Point ... come together on Thanksgiving Day to share the things that they are most ... Serenity Point YouTube channel, patients displayed what they wrote on index cards, describing ...
(Date:11/26/2015)... ... November 26, 2015 , ... ... to discuss bioavailability and the need to integrate dose form selection in early ... with OBN, the membership organization supporting and bringing together the UK’s emerging life ...
(Date:11/26/2015)... ... November 26, 2015 , ... Pixel ... self-animating trailer titles with ProTrailer: Vintage. This newly styled ProTrailer pack comes with ... work with any font, giving users limitless opportunities to stylize and create designs ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 26, 2015 Research and Markets ( ) ... Pacemaker Market Outlook to 2019 - Rise in Cardiac Disorders ... report to their offering. Boston ... Boston scientific and others. --> ... Biotronik, Boston scientific and others. ...
(Date:11/26/2015)... 26, 2015 ... "2016 Future Horizons and Growth Strategies ... Market: Supplier Shares, Country Segment Forecasts, Competitive ... offering. --> ) has ... Future Horizons and Growth Strategies in the ...
(Date:11/26/2015)... 2015 ) has ... of High Viscosity Drugs" report to their ... the addition of the "Self Administration of ... --> Research and Markets ( ... "Self Administration of High Viscosity Drugs" report ...
Breaking Medicine Technology: