Navigation Links
Simple Test May Identify Breast Cancer Subtypes
Date:5/7/2010

These classifications can help explain different outcomes for women with similar-looking tumors, expert says

FRIDAY, May 7 (HealthDay News) -- Classification of breast cancer into subtypes can be achieved through a simple genetic test that uses only three genes, U.S. researchers say.

They analyzed 32 gene expression data sets, including more than 4,600 breast cancer patients and six classification models.

"We studied these models in terms of concordance and prognostic value and, for the first time, we estimated their robustness: that is, their capacity to assign the same tumors to the same molecular subtypes whatever the gene expression data used to fit this model," Dr. Benjamin Haibe-Kains, of the Dana-Farber Cancer Institute in Boston, said in a news release from the European Society for Medical Oncology.

A simple test that uses three genes -- ESR1, ERBB2 and AURKA -- was found to be highly effective in identifying breast cancer subtypes.

The study was to be presented Thursday at the IMPAKT Breast Cancer Conference in Brussels, Belgium.

It's long been known that breast cancer isn't one biologically identical disease, but includes several molecular subtypes that have distinct gene expression profiles.

"It is these differences that explain, at least in part, why patients who have tumors that appear to be similar may experience completely different clinical outcomes such as prognosis and response to anticancer therapies," Haibe-Kains said in the news release. "Thus, there is an urgent need for developing a robust tool to provide clinicians with guidance for classifying breast cancer molecular subtypes, which could then aid in making therapeutic decisions."

More information

The American Cancer Society has more about breast cancer.



-- Robert Preidt



SOURCE: European Society for Medical Oncology, news release, May 6, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. SimpleWebBox Offers Free Websites for Non-Profit Organizations
2. Monkey Brain Hardwired for Simple Math
3. Shamy & Shamy Launches New Web Site Providing Simple Access to Free Online Resources for New Jersey Court System
4. Father Channels His Grief into Advocacy, Promotes Simple Actions to Make Hospitals Safer for Children
5. Simple Concussion Test Measures Reaction Time
6. UAB-led study shows simple steps could reduce stillbirths by up to 1 million
7. NationalCreditReport.com Offers Simple Tax Saving Tips That Can Improve Credit Scores
8. Many With Arthritis Find Simple Solutions for Relief
9. Simple Forms Help Docs Do Better Breast Exams
10. The Simple and Revolutionary Power to OUTSMART YOUR GENES Out April 6th -- Predictive Medicine Pioneer Dr. Brandon Colby Releases Book
11. Simple Test May Spot Early Lung Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... , ... April 28, 2016 , ... Head Over Heels ... 9 Western Championships. The competition will be held at the University of Montana on ... gymnasts west of the Mississippi River. , In order to qualify, Varize needed to ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... open availability of a new CDISC standard, Clinical Trial Registry (CTR) XML. ... This innovative standard will make it possible to build applications that generate ...
(Date:4/28/2016)... ... April 28, 2016 , ... Cosmetic Town, an online ... cosmetictown.com . The forum section was recently revamped and upgraded to allow even more ... in use across the country. , According to the senior editor of Cosmetic Town, ...
(Date:4/28/2016)... ... 2016 , ... Greener Hydroponics is now offering a large selection of Smart ... organic farmers and nurseries according to Sales Manager Joe Steele who says, “Now is ... is to offer wholesale level pricing and ultra-fast shipping for growers of any size.” ...
(Date:4/28/2016)... ... April 28, 2016 , ... In 2011, TIME magazine ... the emerging field of biomechatronics, technology that marries human physiology with electromechanics. He continues ... He is also the Founder of BionX , a leader in the field ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... 27, 2016 ... in Zürich gab Strekin AG den Start ... zur Erhaltung des Resthörvermögens von Patienten, denen ... die umfassende Phase-II-Doppelblindstudie mit Placebo-Kontrollgruppe werden momentan ... wird während der Operation direkt ins Mittelohr ...
(Date:4/27/2016)... PARIS , April 27, 2016 ... Year-Over-Year Including 42% Growth in Recurring Consumable Sales  ... Mauna Kea Technologies (Euronext: MKEA, OTCQX: MKEAY) ... today announced its sales for the first quarter ended ... business and the execution of its commercial strategy. ...
(Date:4/27/2016)... 2016 Transparency Market Research has ... - Global Industry Analysis, Size, Share, Growth, Trends, and ... global skincare devices market was valued at US$ 7,255.8 ... a CAGR of 10.1% from 2015 to 2023 to ... the full Skincare Devices Market (Treatment Device - LED Therapy ...
Breaking Medicine Technology: