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Simple Breath Test Might Diagnose Heart Failure
Date:3/26/2013

nd symptoms, and a physical exam in which a doctor will listen to a patient's heart and lung sounds, and check ankles, feet, legs and abdomen for signs of fluid buildup. Blood tests and an electrocardiogram can help confirm that heart failure exists.

In the new study, to gauge how well the noninvasive breath test could identify heart failure, the team collected exhaled breath samples from 41 patients who had been admitted as in-patients to the Cleveland Clinic.

Of those, 25 had been admitted with a primary diagnosis of "acute decompensated heart failure" while another 16 patients had shown no signs of heart failure but did have other cardiovascular issues. A single breath sample was obtained from each of the patients within 24 hours of admission, as well as from an additional 36 patients with acute decompensated heart failure as an independent point of comparison.

Within two hours of collection, all the samples were subject to the breath test analysis, which relied upon "mass spectrometry" technology to scan the samples for their molecular and chemical compound content. Some of those compounds had been pegged as potential telltale signs of heart failure.

The result: The breath test correctly identified all the patients with heart failure, clearly distinguishing them from those cardiac cases where heart failure was not an issue.

Dr. Gregg Fonarow, a professor of cardiology at the University of California, Los Angeles, said that if further research were able to establish its effectiveness, a breath-driven tool for identifying heart failure would be a helpful diagnostic innovation -- but more so in a doctor's office or clinic than in the hospital.

"If it is clear that it is highly reliable and specific and sensitive, then yes, it would be a welcome advance," he said. "But I would say it would be perhaps more helpful for primary care physicians in an outpatient setting, because that is where it's most challenging to identify heart f
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