Navigation Links
Simple Breath Test Might Diagnose Heart Failure
Date:3/26/2013

By Alan Mozes
HealthDay Reporter

MONDAY, March 25 (HealthDay News) -- An experimental breath test, designed to quickly identify patients suffering from heart failure simply by analyzing the contents of a single exhaled breath, has demonstrated promise in early trials, a team of researchers says.

The investigators stressed that their evaluation is based on a small group of participating patients, and that more extensive research will have to be done to confirm their initial success.

But by subjecting a patient's breath to a rigorous but fast analysis of the hundreds of so-called volatile organic compounds contained therein, the study team said it has so far been able to correctly diagnose heart failure among newly hospitalized patients with a 100 percent accuracy.

"Every individual has a breath print that differentiates them from other people, depending on what's going on in their body," explained study lead author Dr. Raed Dweik, a staff physician in the department of pulmonary, allergy and critical care medicine with the Respiratory Institute at Cleveland Clinic. "And that print can tell us a lot about a person, what they've been exposed to and what disease they have," he added.

"That's what makes the new field of breath testing so promising, because it is non-intrusive, so there is no risk involved," Dweik said. "And you can do it anywhere, in a clinic, in a hospital, anywhere."

The findings were published March 25 in the Journal of the American College of Cardiology.

The study authors pointed out that the most common reason American patients are admitted to a hospital is when there is a suspicion of heart failure -- a tough-to-treat condition in which the heart's pumping action grows gradually weaker over time.

Currently, a diagnosis of heart failure comes from a variety of factors, according to the U.S. National Heart, Lung, and Blood Institute. These include medical history and symptoms, and a physical exam in which a doctor will listen to a patient's heart and lung sounds, and check ankles, feet, legs and abdomen for signs of fluid buildup. Blood tests and an electrocardiogram can help confirm that heart failure exists.

In the new study, to gauge how well the noninvasive breath test could identify heart failure, the team collected exhaled breath samples from 41 patients who had been admitted as in-patients to the Cleveland Clinic.

Of those, 25 had been admitted with a primary diagnosis of "acute decompensated heart failure" while another 16 patients had shown no signs of heart failure but did have other cardiovascular issues. A single breath sample was obtained from each of the patients within 24 hours of admission, as well as from an additional 36 patients with acute decompensated heart failure as an independent point of comparison.

Within two hours of collection, all the samples were subject to the breath test analysis, which relied upon "mass spectrometry" technology to scan the samples for their molecular and chemical compound content. Some of those compounds had been pegged as potential telltale signs of heart failure.

The result: The breath test correctly identified all the patients with heart failure, clearly distinguishing them from those cardiac cases where heart failure was not an issue.

Dr. Gregg Fonarow, a professor of cardiology at the University of California, Los Angeles, said that if further research were able to establish its effectiveness, a breath-driven tool for identifying heart failure would be a helpful diagnostic innovation -- but more so in a doctor's office or clinic than in the hospital.

"If it is clear that it is highly reliable and specific and sensitive, then yes, it would be a welcome advance," he said. "But I would say it would be perhaps more helpful for primary care physicians in an outpatient setting, because that is where it's most challenging to identify heart failure. Today a diagnosis in that environment is based on a patient's history and exam, but symptoms for heart failure can easily overlap with a lot of other diagnoses. And the blood work that would be taken in a doctor's office might not come back until the next day, delaying identification," he noted.

"So a breath test would be most useful in that kind of challenging situation," Fonarow said. "But in an emergency room, while there are challenges as well, bedside blood tests are much more readily drawn and quickly analyzed so you can often get the results in minutes. So there may be potentially less of a role for a breath test in that kind of setting."

Study author Dweik added that the test is "theoretically cheap. But of course we're still early in the process of exploring its potential. This study is really a proof of concept. There is much more work that needs to be done to get it to the point where it would become widely available."

More information

For more on heart failure, visit the U.S. National Heart, Lung, and Blood Institute.

SOURCES: Raed Dweik, M.D., staff physician, department of pulmonary, allergy and critical care medicine, Respiratory Institute at Cleveland Clinic; Gregg C. Fonarow, M.D., professor, cardiology, University of California, Los Angeles; March 25, 2013, Journal of the American College of Cardiology


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Simple assault and ground level fall do not require cervical spine CT
2. Prosthetic retina offers simple solution to restoring sight
3. Cancer may require simpler genetic mutations than previously thought
4. Safe, simple eye test may help save lives by preventing stroke
5. Simple new way to clean traces of impurities from drug ingredients
6. Simpler lifestyle found to reduce exposure to endocrine-disrupting chemicals
7. Simple exercises are an easy and cost-effective treatment for persistent dizziness
8. Simple Steps Can Shield Children From Dog Bites
9. Simple Measures May Curb Excessive Weight Gain in Pregnancy
10. Simple mathematical computations underlie brain circuits
11. Simple new test to combat counterfeit drug problem in developing countries
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Simple Breath Test Might Diagnose Heart Failure
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating ... Millions of individuals in the United States and Canada wear eyeglasses. Once considered to ... correct vision and make a fashion statement. Even celebrities use glasses as a way ...
(Date:6/26/2016)... ... ... Kasmer, a legally blind and certified personal trainer is helping to develop a weight loss ... plans to fix the two major problems leading the fitness industry today:, ... , They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily ... of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures ... . Simply select a ProHand generator and drag it above media or text in ...
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... 24, 2016 , ... The Pulmonary Hypertension Association (PHA) learned ... receive two significant new grants to support its work to advance research and ... by recognizing patients, medical professionals and scientists for their work in fighting pulmonary ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... Jazz Pharmaceuticals plc (Nasdaq: JAZZ ... Antitrust Improvements Act of 1976, as amended ("HSR"), with ... ("Celator"; Nasdaq: CPXX ) expired effective June ... As previously announced on May 31, 2016, Jazz ... under which Jazz Pharmaceuticals has commenced a tender offer ...
(Date:6/26/2016)... 2016 Story Highlights: ... within the health care industry is causing providers to ... , Deloitte offers a suite of solutions for health ... efficient cost optimization: labor resource analysis, revenue cycle optimization ... better outcomes and better economics ...
(Date:6/24/2016)... 24, 2016  Collagen Matrix, Inc., ("Collagen Matrix") ... manufacturing of collagen and mineral based medical devices ... Bill Messer has joined the company ... leverage the growing portfolio of oral surgery, neurosurgery, ... Bill joins the Collagen Matrix executive team as ...
Breaking Medicine Technology: