Navigation Links
Simple, inexpensive and objective tools for the assessment of mucosal inflammation: fecal markers
Date:9/24/2008

UC and CD, the two major forms of IBD are chronic, idiopathic inflammatory conditions of the gut with a typically relapsing and remitting course. A prominent feature in mucosal biopsies from patients with active IBD is infiltration by neutrophil granulocytes. Moreover, the number of eosinophil granulocytes is also increased in IBD. Upon activation, neutrophils release Calprotectin and MPO, two major neutrophil proteins, while eosinophils release the protein, EPX. Previous studies have shown that fecal markers may be used to differentiate IBD from functional gastrointestinal disorders, but the usefulness of these markers in monitoring therapy of patients with active relapse of IBD needs further evaluation.

A research article to be published on September 28, 2008 in the World Journal of Gastroenterology addresses this question. A research team led by Associate professor M Carlson, Department of Medical Sciences, Uppsala University, evaluated patients with previously diagnosed UC or CD before starting treatment, and after 4 and 8 week of treatment. Treatment outcome, based on clinical activity and endoscopic findings in UC patients, and clinical activity in CD patients, was evaluated together with fecal levels of FC, and compared with fecal MPO and EPX. Fecal samples were analyzed for FC with ELISA, and MPO and EPX with RIA.

The authors have previously reported that elevated fecal levels of EPX and MPO may be useful in monitoring therapy in UC. The present study confirmed previous findings that patients with a relapse of IBD had elevated fecal markers. Interestingly, this study also demonstrated that normalized FC level may be used as a surrogate marker for successful treatment outcome in IBD patients. However, patients with persistently elevated FC levels need further evaluation. FC and MPO provided better assessment of treatment outcome than EPX in patients with UC, whereas EPX has the potential to identify treatment outcome, especially in patients with CD. These findings suggest that fecal markers can be used as surrogate markers for successful treatment outcome in IBD patients. Fecal markers are simple, inexpensive and objective tools for the assessment of mucosal inflammation.


'/>"/>

Contact: Jian-Xia Cheng
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. New OPAL Therapy presents simple, cost-effective method of treating HIV infection
2. AUDIO from Medialink and Bayer: Simple, Focused Ways to Boost Womens Health
3. Simple, personalized interventions improve colorectal cancer screening rates
4. If you think cancer genes are simple, you dont know JAK
5. Handbooks in Health Care Company Offers Full Line of Inexpensive Educational Pocket Books
6. Inexpensive Compound Could Treat Severe Diarrhea
7. Study Finds Nearly One-Third of All Inexpensive Earrings Examined Tested Positive for Nickel
8. Study: Before a CT scan or angiogram, many people should take inexpensive drug to protect kidneys
9. Inexpensive Online Pain Education Program for Physicians as Effective as Live Presentations by National Experts
10. Neurochem reports results for fourth quarter and fiscal year 2007 and important advances on corporate objectives
11. Sangamo BioSciences Provides Update on Companys Accomplishments in 2007 and 2008 Objectives
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... ... 2017 , ... Neil H. Greco Insurance Agency, a northern New Jersey firm ... is launching a charity drive to raise awareness of heart disease and promote habits ... America, and is responsible for 1 in every 4 deaths at the national level ...
(Date:1/17/2017)... ... January 17, 2017 , ... Physicians Education ... Lee as keynote speaker for the 34th Annual Miami Breast Cancer Conference®, on ... announcement, PER® president, Phil Talamo, said, “We are delighted to have Sandra Lee ...
(Date:1/17/2017)... ... January 17, 2017 , ... Twelve ... State University’s Athletic Training Education program forged a relationship built upon the foundation ... Program, which is consists of both student members and certified members of the ...
(Date:1/16/2017)... Village, IL (PRWEB) , ... January 16, 2017 ... ... personal audio products, will demonstrate their groundbreaking GunSport•PRO® and EB15•LE® electronic earplugs at ... Convention Center in Las Vegas, Booth #2809. The SHOT Show is the shooting, ...
(Date:1/16/2017)... ... January 16, 2017 , ... Permobil has just ... brand of custom seating systems has a well-earned reputation for premium quality, with ... for innovation and growth in the custom seating business, which enjoys strong demand, ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... , Jan 17, 2017 Research and ... Market 2016-2020" report to their offering. ... The global laparotomy sponges market to ... Global Laparotomy Sponges Market 2016-2020, has been prepared ... The report covers the market landscape and its growth prospects over ...
(Date:1/17/2017)...  ANI Pharmaceuticals, Inc. ("ANI") (Nasdaq: ... Quinn Ph.D as Vice President Corticotropin Regulatory Affairs, ... Karen Quinn is a professional with over ... Affairs, specifically with a focus on drug products ... most recently with Takeda Pharmaceuticals International as Senior ...
(Date:1/17/2017)... , Jan. 17, 2017  Bayer today announced the appointment ... Pharmaceuticals business in the Americas, comprising the United ... Latin America . In this role, Dr. ... the Board of Management of Bayer AG and President of ... highly respected leader in the pharmaceutical industry and I,m delighted ...
Breaking Medicine Technology: