Navigation Links
Simons Foundation grant boosts brain tumor research

NEW YORK, January 31, 2008 A $10 million commitment from James H. and Marilyn H. Simons through the Simons Foundation will support preclinical initiatives undertaken as part of Memorial Sloan-Ketterings new Brain Tumor Center (BTC).

Established in 2007, the BTC is designed to achieve fundamental new insights into the molecular and cellular properties that drive tumor development and growth. Investigators plan to apply that knowledge to the creation of therapies that target cancer cells and the abnormal signaling pathways needed to maintain them.

With its emphasis on carrying discoveries from the basic and translational research laboratory all the way to clinical trials, the BTC offers the potential for meaningful progress against one of the most challenging forms of cancer.

We are grateful to Jim and Marilyn Simons for their foresight and generosity in helping to get the Brain Tumor Center off to a strong start, said Harold Varmus, Memorial Sloan-Ketterings President. The work to be done through the BTC is highly complex, but absolutely essential, and we welcome the Foundations support in moving forward.

The grant from the Simons Foundation will underwrite preclinical studies of new therapies to confirm that they produce their desired effect in animal models. There currently exists no drug pipeline developed specifically for gliomas, and such preclinical work is an essential step in the design of new therapies for use in humans.

Brain cancer poses a particular challenge to treatment, in part because of the difficulties involved in getting drugs to cross the blood-brain barrier, which physically shields the brain from chemicals circulating in the body. There are also concerns about the potential side effects of drugs that do succeed in entering the brain. The highly precise treatments developed through the BTC will be designed to destroy cancer cells while sparing nearby sensitive tissues an especially important consideration in dealing with the brain.

Helping to guide the development of the BTC have been three physicians who bring a breadth of expertise to the project: Lisa M. DeAngelis, Chair of the Department of Neurology, Philip H. Gutin, Chair of the Department of Neurosurgery, and Eric C. Holland, a neurosurgeon and member of the Sloan-Kettering Institutes Cancer Biology and Genetics Program who is the BTCs founding director.

My colleagues and I are overwhelmed by the confidence that the Simons Foundation has shown in the work of the Brain Tumor Center and in the collaborative spirit that is at its heart, said Dr. Holland. This gift provides solid footings for the program and will dramatically accelerate the development of its preclinical and clinical components, which together are key to identifying new therapeutic approaches.

The Simons Foundations support for the Brain Tumor Center extends its commitment to promoting innovation in mathematics, physics, and other sciences a commitment exemplified by its Autism Research Initiative, which supports wide-ranging neuroscience research with the goal of improving the diagnosis, treatment, and prevention of autism and related conditions. Indeed, work conducted through the BTC into the biology of gliomas which arise from supporting tissue known as glia has the potential to shed new light on the role of glial cells in autism and a variety of neurodegenerative and neurodevelopmental disorders.


Contact: Christine Hickey
Memorial Sloan-Kettering Cancer Center

Related medicine news :

1. The Chrysler Foundation and Kenosha Engine Plant Donate $100,000 to New YMCA Aquatics Center
2. The UV Foundation Announces February is Vitamin D Deficiency Month
3. Michael J. Fox Foundation awards up to $3 million to industry teams
4. AMERIGROUP Foundation Announces Winners of Word About Health Contest
5. Dannemiller Memorial Education Foundation and GR MedEd, Inc. Announce Oncology Summit: From Discovery to Delivery
6. Fernandez Appointed to Blue Cross Foundation Board
7. Inspector Hector(R), National Childrens Oral Health Foundation Kick Off Events for National Childrens Dental Health Month
8. Asthma Foundation Announces 2008 Asthma Capitals, Knoxville on Top Again
9. Helios Education Foundation Invests $6.5 Million in New Partnership with TGen
10. The Highmark Foundation Awards $4 Million in Highmark Healthy High 5 Grants to Two Nonprofit Organizations
11. American Legacy Foundation Comments on New York State Department of Health Petition to the FDA to Expand Consumer Access to Over the Counter Nicotine Medications
Post Your Comments:
(Date:6/27/2016)... ... June 27, 2016 , ... The OSHA Training Center ... Education Center headquartered in Northern California, has issued an important reminder to employers ... worksites. Employers with workers exposed to high temperatures should establish a complete ...
(Date:6/27/2016)... ... , ... "FCPX editors can now reveal their media with growing colorful split ... Austin - CEO of Pixel Film Studios. , ProSlice Color brings the split ... now reveal the media of their split screens with growing colorful panels. , ProSlice ...
(Date:6/27/2016)... ... June 27, 2016 , ... TherapySites, ... its affiliation with Tennessee Counseling Association. This new relationship allows TherapySites ... Tennessee Counseling Association, adding exclusive benefits and promotional offers. , "TCA is extremely ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... payment industry today announced its strategic partnership with Connance, a healthcare industry ... The two companies’ proven, proprietary technology combine to provide health systems, hospitals ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... technology to revolutionize the emergency ambulance transport experience for the millions of people ... how Uber has disrupted the taxi industry through the use of technology. Now, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 , ... Thursday, July 7, 2016 , , , , LOCATION: , ... , , , , EXPERT PANELISTS:  , , , Frost ... Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh ... The global pharmaceutical industry is witnessing an exceptional era. Several ...
(Date:6/23/2016)... , June 23, 2016 ... Oticon , industry leaders in advanced ... launch of Oticon Opn ™, the world,s first ... of possibilities for IoT devices.      (Photo: ... Oticon introduces a number of ,world firsts,: ...
(Date:6/23/2016)... 2016 Research and Markets has ... Global Analysis (United States, China, Japan, Brazil, United Kingdom, ... their offering. Surgical ... business planners, provides surgical procedure volume data in a ... an in-depth analysis of growth drivers and inhibitors, including ...
Breaking Medicine Technology: