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Similar outcomes in older patients with on- or off-pump bypass

SAN FRANCISCO (March 11, 2013) Older patients did as well after undergoing coronary bypass surgery off-pump as they did with the more costly "on-pump" procedure using a heart-lung machine to circulate blood and oxygen through the body during surgery, according to research presented today at the American College of Cardiology's 62nd Annual Scientific Session.

This large, multicenter trialthe German Off-Pump Coronary Artery Bypass Grafting in Elderly Patients, called GOPCABEwas the first to evaluate on-pump versus off-pump bypass surgery among patients aged 75 or older. The primary endpoint was individual patients' combined outcomes of death, stroke, heart attack, repeat revascularization or new renal replacement therapy within 30 days of surgery. Researchers found no significant difference in the primary endpoint between patients receiving the on-pump and off-pump procedures (8.2 vs. 7.8 percent, p = 0.74).

"Our study shows that coronary bypass surgery can be performed in the elderly population with excellent results, and this is equally true for both techniques," said Anno Diegeler, MD, PhD, head of the department of cardiovascular surgery at the Heart Center Bad Neustadt in Germany and the study's lead investigator. "These findings suggest clinicians can select the lower cost off-pump procedure without risk to the patient."

Coronary artery bypass graft surgery, or CABG, is one of the most commonly performed operations in the U.S. and the world and consumes more resources in cardiovascular medicine than any other procedure. In on-pump CABG, the patient's heart is stopped and blood is circulated through a heart-lung machine, where it is oxygenated and returned to the patient. In the off-pump technique, the surgeon uses a retractor to lift the still-beating heart and perform all coronary artery grafts. Off-pump CABG eliminates the need to insert a tube called a cannula into the aorta (the main artery distributing blood to the brain and body), cross-clamp the aorta, connect the patient to the heart-lung machine, and stop and restart the heart.

Previous studies comparing the two techniques also found similar results for on-pump and off-pump CABG, but none of these studies focused exclusively on elderly patients. To address concerns that the elderly may not benefit equally from both techniques because of their higher risks, GOPCABE enrolled 2,539 patients aged 75 or older scheduled for elective, first-time CABG in 12 cardiovascular centers in Germany.

Patients were randomized to receive on-pump or off-pump CABG. Results for all components of the primary endpoint were similar between the groups at 30 days. Patients had no significant differences in rates of death (2.8 vs. 2.6 percent), stroke (2.7 vs. 2.2 percent), heart attack (1.7 vs. 1.5 percent), and new renal replacement therapy (3.1 vs. 2.4 percent), and a slim difference in repeat revascularization (0.4 vs. 1.3 percent). At 12 months, researchers again found no significant difference in the composite endpoint between on- and off-pump (14.0 vs. 13.1 percent, p = 0.483). Study results are important for surgeons who favor off-pump surgery, Dr. Diegeler said.

"For surgeons who prefer off-pump surgery, our study confirms that off-pump CABG is safe and the quality is equal to on-pump surgery for elderly patients. At 12 months, we had a survival rate of 93 percent among our off-pump patients and 92 percent for on-pump," he said. He notes that the surgeon's level of experience is critical in assessing the two techniques.

According to Dr. Diegeler, the similar result from both techniques is beneficial to facilities and patients in developing countries, where the on-pump procedure may come at a higher cost since instruments used in off-pump CABG can be re-sterilized, but components of the machine used in on-pump cannot.

While this study provides support for the efficacy and safety of both CABG techniques in the elderly, Dr. Diegeler said further work is needed to look at CABG outcomes in other special populations, including patients deemed high-risk for surgery.


Contact: Beth Casteel
American College of Cardiology

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