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Silicone Breast Implants Might Raise Risk of Rare Lymphoma
Date:11/4/2008

re are no known risk factors.

The authors of this study, at the Netherlands Cancer Institute in Amsterdam, searched a national database in the Netherlands for all cases of lymphoma in the breast diagnosed between 1990 and 2006.

They found 11 patients with ALCL, five of whom had had breast implants one to 23 years before their diagnosis. This was out of a total population of 8 million Dutch women over 17 years.

Compared with women who had other types of lymphoma in the breast, women with silicone breast implants had an 18-fold greater risk for developing ALCL.

The authors hypothesized that an immune system response related to placement of the implants or toxic damage from the implants might explain the association.

"There has been a lot of information about silicone and autoimmune disorders," Smith said. "Lymphomas do occur in other immune-deficiency states where you have chronic stimulation of parts of the immune system. It makes some sort of sense that this could happen."

More information

Visit The Leukemia & Lymphoma Society for more on different types of lymphoma.



SOURCES: Mitchell Smith, M.D., Ph.D., head, lymphoma service, Fox Chase Cancer Center, Philadelphia; Nov. 5, 2008, Journal of the American Medical Association


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