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Silencing small but mighty cancer inhibitors
Date:12/10/2007

he program of genes that are expressed in cancer cells.

Still, we needed to determine whether any of these Myc-regulated microRNAs played a direct role in cancer, adds Thomas-Tikhonenko. His team then individually reintroduced several of the repressed miRNAs into mouse lymphomas that also had high levels of Myc and measured the effect on lymphoma progression in animals. They found that more than five of the miRNAs could stop cancer growth. While this result was not entirely surprising, we had no idea that cancer suppression by microRNAs could be so powerful, admits Thomas-Tikhonenko. Mendell also notes that RNA-based therapies have had some success in animal models, and researchers might potentially find a wide range of miRNAs that can stop cancers in their tracks.


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Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
Source:Eurekalert

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