Navigation Links
Silencing small but mighty cancer inhibitors
Date:12/10/2007

Researchers from Johns Hopkins and the University of Pennsylvania have uncovered another reason why one of the most commonly activated proteins in cancer is in fact so dangerous. As reported in Nature Genetics this week, the Myc protein can stop the production of at least 13 microRNAs, small pieces of nucleic acid that help control which genes are turned on and off.

Whats more, in several instances, re-introducing repressed miRNAs into Myc-containing cancer cells suppressed tumor growth in mice, raising the possibility that a sort-of gene therapy approach could be effective therapy for treating certain cancers.

A research team led by Joshua Mendell, M.D., Ph.D., assistant professor at the McKusick-Nathans Institute of Genetic Medicine, previously found that Myc could turn on one particular group of growth-promoting miRNAs called the miR-17-92 cluster in lymphoma cells. His team, along with Andrei Thomas-Tikhonenkos lab at the University of Pennsylvania, now took a broader approach and analyzed more than 300 miRNAs in both human and mouse lymphoma cells.

In those cells that had high amounts of Myc protein, the researchers found significant changes in the quantities of at least 13 miRNAs. The surprising aspect, considering our miR-17-92 results, says Tsung-Cheng Chang, lead author on the study, is that lots of Myc turns everything off, not on.

When they looked closer at the DNA of the lymphoma cells, the team also found that Myc was directly attaching to the DNA at the miRNA genes. This was further evidence that the decrease in miRNA levels was directly due to the action of Myc, says Chang.

This study expands our understanding of how Myc acts as such a potent cancer-promoting protein, says Mendell. We already knew that it can directly regulate thousands of genes. Through its repertoire of miRNAs, Myc likely influences the expression of thousands of additional genes. Activation of Myc therefore profoundly changes t
'/>"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Prophylactic cranial irradiation in small cell lung cancer significantly increases survival
2. American Red Cross and FedEx Announce Collaboration to Help Small Businesses Get Prepared for Disaster
3. iCAD to Present at William Blair & Company Small-Cap Growth Stock Conference
4. Governor Rendell Announces $2.1 Million Investment in Small Transit Vehicles
5. Karen Vigil Named Senior Vice President and Chief Executive Officer, Blue Shield of Californias Individual, Small Group, and Government Business Unit
6. Small Incisions Make Heart Valve Surgery Safer
7. Smaller breast reduction surgeries provide health benefits and should be reimbursed
8. Exponent to Present at the Upcoming Sidoti & Company Investor Forum and William Blair Small-Cap Growth Stock Conference
9. Activate America(R) Brings Together YMCAs Nationwide to Promote Small Steps Toward a Healthier Lifestyle During America on the Move Week With the YMCA, September 22-29, 2007
10. Small Bone Innovations Introduces the Artelon(R) STT Spacer to Increase Treatment Options for Thumb Arthritis
11. Small Army Takes on Cure for Diabetes and New Approach to Ending World Poverty with Addition of Non-Profit Accounts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... September 17, 2014 The Delta Dental ... to the National Children’s Oral Health Foundation: America’s ToothFairy ... NCOHF’s Orange County Oral Health Zone Program® in California. ... is engaging a range of local constituent groups and ... of severe tooth decay and its devastating effects on ...
(Date:9/17/2014)... News) -- Managing diabetes, quitting smoking, controlling high blood ... the risk for dementia -- even late in life, ... Report 2014, commissioned by Alzheimer,s Disease International, revealed that ... percent. The study noted that obesity and an inactive ... as high blood pressure. The researchers suggested ...
(Date:9/17/2014)... care system is not properly designed to meet the ... those of their families, and major changes to the ... Institute of Medicine. The 21-member committee that wrote ... integrates traditional medical care and social services and that ... for more "advance care planning" for end-of-life by individuals, ...
(Date:9/17/2014)... shown that most 18-month-olds learn an average of two ... known about how children process information to learn new ... a new study, a University of Missouri researcher has ... and a limit exists as to how many words ... parents enhance their children,s vocabularies and assist speech-language professionals ...
(Date:9/17/2014)... (PRWEB) September 17, 2014 CarePoint Health ... when over 150 CarePoint Health employees participated in the ... the ALS Association. The event took place on ... Medical Center. CarePoint Health donated $100 to the ALS ... for a total of approximately $15,000. The Ice Bucket ...
Breaking Medicine News(10 mins):Health News:Delta Dental Community Care Foundation Donation to America's ToothFairy Helps Deliver Critical Services 2Health News:Healthy Lifestyle Changes Linked to Reduced Risk for Dementia 2Health News:Healthy Lifestyle Changes Linked to Reduced Risk for Dementia 3Health News:US health system not properly designed to meet needs of patients nearing end of life, says IOM 2Health News:US health system not properly designed to meet needs of patients nearing end of life, says IOM 3Health News:US health system not properly designed to meet needs of patients nearing end of life, says IOM 4Health News:US health system not properly designed to meet needs of patients nearing end of life, says IOM 5Health News:Babies learn words differently as they age, researcher finds 2Health News:CarePoint Health Accepts the Ice Bucket Challenge 2Health News:CarePoint Health Accepts the Ice Bucket Challenge 3
... study of young U.S. teens showed that between 11 ... an alcohol brand, and those who do appear more ... susceptibility, to beginning drinking, to binge drinking, according to ... of Pediatrics & Adolescent Medicine . , Alcohol-branded merchandise ...
... (Nasdaq: AIRM ) will report financial results for ... of the market on Tuesday, March 10, 2009. The ... 2009 at 4:15 p.m. Eastern to discuss these results. ... (domestic) or (706) 643-8826 (international) or by accessing the web ...
... surgery can restore function for obese males, study finds , , ... man, the greater his hormonal changes and the worse his ... side, the study,s authors found that gastric bypass surgery can ... obesity is correlated to lower sperm count and can be ...
... is best bet, experts say , , TUESDAY, March 3 ... find new solutions to combat the growing resistance to ... , "The startling news about oseltamivir [Tamiflu] resistance should ... effort to cope with this rapidly evolving pathogen," wrote ...
... second overall and first for long-term investment and social ... Diagnostics Incorporated (NYSE: DGX ), the world,s ... again been named to FORTUNE magazine,s list of the ... the "Health Care" category of "Pharmacy and Other Services." ...
... and CEO of the New Canadian EntityWHIPPANY, N.J., March ... company, has announced today that it is establishing a ... Ltd. This company will have its headquarters in Ontario, ... sale and distribution of branded pharmaceutical products currently available ...
Cached Medicine News:Health News:Owning alcohol-branded merchandise associated with teen drinking behaviors 2Health News:Men's Sex Lives May Suffer as Waistlines Expand 2Health News:Concerted Effort Needed to Fight Drug-Resistant Flu Strain 2Health News:Concerted Effort Needed to Fight Drug-Resistant Flu Strain 3Health News:Quest Diagnostics Again Named to FORTUNE Magazine's 'World's Most Admired Companies' List 2Health News:Halo Pharmaceutical Launches a Branded Product Marketing Company in Canada 2
(Date:9/17/2014)... OTEMR, Inc. , ONETOUCH EMR, 2.0 has achieved ONC ... the software is capable of supporting eligible providers with ... measures required to qualify for funding under the American ... certified on July 14, 2014 by ICSA Labs ... (ONC-ACB) and is compliant in accordance with applicable criteria ...
(Date:9/17/2014)... 17, 2014  Lightbeam Health Solutions announced today ... (Physician Direct ACO) to deploy the Lightbeam population ... better care while reducing costs. Photo ... Direct Accountable Care Organization is the ACO operating ... OPNS mission is to be the premier integrated ...
(Date:9/17/2014)... --  myMatrixx, a pharmacy and ancillary medical benefit manager for workers, ... has awarded myMatrixx with a "Best Places to Work ... row. Best Places to Work is ... Best Companies Group.  The competition, which involves months of ... insurance industry companies with at least 25 employees in ...
Breaking Medicine Technology:OTEMR, Inc.'s ONETOUCH EMR Achieves ONC HIT 2014 Edition COMPLETE EHR Certification from ICSA Labs 2OTEMR, Inc.'s ONETOUCH EMR Achieves ONC HIT 2014 Edition COMPLETE EHR Certification from ICSA Labs 3Physician Direct Accountable Care Organization Selects Lightbeam Health to Enable Better Care at a Lower Cost 2Physician Direct Accountable Care Organization Selects Lightbeam Health to Enable Better Care at a Lower Cost 3myMatrixx Honored with "Best Places to Work in Insurance" Award 2
... Aug. 11, 2011 Lexicon Pharmaceuticals, Inc. ... on discovering breakthrough treatments for human disease, announced today ... president and chief executive officer, will present at the ... August 16, 2011 at 1:15 p.m. Eastern Time in ...
... Minn., Aug. 11, 2011 The City of St. Louis ... to help provide residents with some relief from the high ... the National League of Cities (NLC) – the City is ... discount cards offer city residents an average of 23 percent ...
Cached Medicine Technology:Lexicon Pharmaceuticals to Present at the Wedbush 2011 Life Sciences Management Access Conference 2St. Louis Park and the National League of Cities Bring Free Prescription Discount Card Program to Residents 2
This CDI original designed Bra Vest incorporates Velcro® adjustable side closures to provide maximum compression to the patients breast, upper abdomen, upper and lower back....
Female Mini-VEST Seamless, Front Closure...
Male Support Brief...
For Lipoplasty or surgery of abdomen, flanks and midriff...
Medicine Products: