Navigation Links
Silencing hepatitis B virus prevent recurrence of liver cancer
Date:6/24/2010

(PHILADELPHIA) Previous studies have shown that antiviral treatment reduces the incidence of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). But now, researchers from the Division of Gastroenterology and Hepatology at Thomas Jefferson University are reporting that the antiviral therapy also prevents recurrence of HCC and extends patients' lives.

The standard of care for patients with HCC is local ablation of the tumor, unless it is large or has metastasized. However, HCC tumors often recur, or new lesions develop. In the International Journal of Cancer, Hie-Won Hann, M.D., professor of Medicine at Jefferson Medical College of Thomas Jefferson University, and colleagues reported that the median survival in patients who received antiviral therapy after HCC diagnosis was 60 months in patients. In those who did not receive antiviral therapy, the median survival was 12.5 months.

"Before the antiviral drugs were developed, patients would often develop new lesions within a few months of tumor ablation because we were not treating the underlying virus that is causing the liver cancer," Dr. Hann said. "The virus drives the cancer, and by suppressing the virus and making it undetectable we can extend the survival for these patients."

The small study included 15 CHB patients who received local ablation of a single HCC tumor that was less than four cm. The first six patients were diagnosed between 1991 and 1997, prior to the development of antiviral therapy. These patients were considered historical controls.

The other nine patients were diagnosed between 2000 and 2004. These patients began ongoing antiviral therapy with lamivudine immediately after HCC diagnosis. Other antiviral medications, such as tenofovir and adefovir were added to the regimen if resistance to lamivudine developed, or even without drug resistance.

All patients who received the antiviral therapy maintained undetectable hepatitis B virus in serum and continued the therapy. Seven of the nine patients have not developed a new HCC or recurrence. The longest survivors are the two patients who came with HCC in 2000. They are doing well, free of caner for more than 10 years. All patients continue with the antiviral therapy and are followed at three to four month intervals.

"The other option for these patients is liver transplantation, which carries its own risks," said Robert Coben, M.D., associate professor of Medicine at Jefferson Medical College of Thomas Jefferson University, who was involved in the study. "This is an attractive alternative for this patient population."


'/>"/>

Contact: Emily Shafer
emily.shafer@jefferson.edu
215-955-6300
Thomas Jefferson University
Source:Eurekalert

Related medicine news :

1. NVHR: Administrations 2011 Budget Proposal Shortchanges Five Million Americans Afflicted with Chronic Viral Hepatitis
2. NVHR Issues Challenge to Administration, Congress: Dont Leave 5 Million Americans Afflicted with Chronic Viral Hepatitis Out in the Cold with Budget Freeze
3. New Treatment Eyed for Hepatitis C
4. Treatment for chronic hepatitis C: A phase II study
5. New Hepatitis C Treatment Shows Promise
6. NVHR Offers Congressman Hank Johnson Support & Encouragement as He Battles Chronic Hepatitis C Virus
7. Hepatitis B Foundation awards UT School of Public Health professor
8. Key to Hepatitis C May Be Two Cellular Proteins
9. IOM report recommends steps to tackle hepatitis B and C
10. New screening system for hepatitis C
11. Groundbreaking research to find vaccine for hepatitis C
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2017)... ... September 19, 2017 , ... Trusted debt-reduction firm CreditAssociates, LLC has announced two ... in excess of $835 million in resolved debt for its clients. , Credit card ... of the categories of debt settled by the company. With more than a decade ...
(Date:9/19/2017)... ... September 19, 2017 , ... ... Canyon Ranch to its recently formed Corporate Roundtable, a group of ... system and a sustainable world. , Canyon Ranch is a unique collection of ...
(Date:9/19/2017)... RESTON, VA (PRWEB) , ... ... ... future of medication management to the present, Mirixa Corporation recently unveiled the ... has continually redefined and reinvented how medication management services are delivered. Based ...
(Date:9/19/2017)... (PRWEB) , ... September 19, 2017 , ... Driving Dynamics ... Safety Training Company by Training Industry Inc. as part of its mission to continually ... , Selection to the first annual 2017 Top 20 Health and Safety Training Companies ...
(Date:9/19/2017)... ... September 19, 2017 , ... ... neurosurgeon, has received a big bump in sales after recently going live ... available on the Wal-Mart Stores-owned Jet.com, StackedNutrtion.com, RonnieColemanNutrition.com, RevNutrition.com and Go4ItNutrition.com. ...
Breaking Medicine News(10 mins):
(Date:8/29/2017)... 2017 ivWatch, LLC, the leading provider of continuous monitoring ... has been awarded an Innovative Technology contract from Vizient, Inc., the ... ... in the early detection of peripheral IV infiltration and extravasation events ... The Innovative Technology contract was awarded to ...
(Date:8/28/2017)... division of LightScalpel ®, LLC, is announcing its new line of ... American veterinary laser surgery innovation, Aesculight® is revolutionizing veterinary laser surgery once ... ... VetScalpel laser. Dr. Duclos practices veterinary dermatology at the Animal Skin and ... ...
(Date:8/24/2017)... -- BioBridges, a Career Portfolio® Management company providing integrated ... announce its corporate sponsorship of the upcoming fourth annual ... event will benefit charitable foundations affiliated with each band. ... to return once again as a sponsor of the ... Jason Falchuk , BioBridges Founding Partner. "Our life sciences ...
Breaking Medicine Technology: