Navigation Links
Silencing a deadly conversation in breast cancer
Date:6/2/2011

While it is already known that breast cancer cells create the conditions for their own survival by communicating their needs to the healthy cells that surround them, Australian researchers have identified a new way of turning off that cellular cross talk.

They have shown that a molecule known as 'hedgehog' sits at the centre of the switchboard in breast cancer, transmitting biochemical signals between the cancer cells and healthy cells.

When this conversation is blocked or hedgehog is 'silenced' tumours shrink and stop their spread.

While the finding applies to all breast cancers, it is particularly relevant for women with basal breast cancer, for which there is no current targeted therapy.

The good news is that drugs for silencing hedgehog are already undergoing Phase 2 clinical trials in other cancer types.

Clinical Associate Professor Sandra O'Toole and Dr Alex Swarbrick, from Sydney's Garvan Institute of Medical Research, analysed breast tumour samples from a cohort of 279 women with advanced breast cancer, revealing that the higher the level of hedgehog, the more aggressive the cancer.

Having discovered high levels of hedgehog in some breast cancer patients, they went on to over-produce the protein in mouse models of basal breast cancer. Mice developed tumours that grew and spread through the body rapidly. When hedgehog was blocked, the tumour growth and spread were significantly slowed.

These findings are published in the prestigious international journal Cancer Research, now online.

"We are hopeful that our findings will drive the progress of clinical trials for anti-hedgehog drugs in breast cancer," said Dr Alex Swarbrick.

"Finding an effective drug target for basal breast cancer is a very high priority. It is often referred to as 'triple negative disease', because it doesn't produce any of the oestrogen, progesterone or HER2 receptors, targets of the drugs tamoxifen and
'/>"/>

Contact: Alison Heather
a.heather@garvan.org.au
61-292-958-128
Research Australia
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Silencing hepatitis B virus prevent recurrence of liver cancer
2. Deadly bacteria may mimic human proteins to evolve antibiotic resistance
3. Cardiac Arrest Less Deadly in Exercise Facilities, Study Finds
4. Belly Fat + Heart Disease Can Be Deadly: Study
5. Gene Variant May Be Linked to Deadly Lung Fibrosis
6. Problem Drinking May Make Hospital Infections More Deadly
7. Possible new approach to treating deadly leukemia in babies
8. Newly discovered virus implicated in deadly Chinese outbreaks
9. Tanning bed exposure can be deadly when complicated by medication reactions
10. Study finds close linkage between a rare, deadly lung condition and blood cell abnormalities
11. Virus Unlikely to Advance Deadly Lung Disease: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... Beach, Calif. (PRWEB) August 30, 2014 Insomnia ... Francis helps listeners understand how they unknowingly developed insomnia and ... have restful nights during. Tune in to the show ... The show airs live on August 30, and will ... more information on programming, go to DrCarolFrancisTalkRadio.com. , ...
(Date:8/30/2014)... 30, 2014 Hastings and Hastings, a ... located throughout Arizona is pleased to report having saved ... specific example among many cases where Hastings and Hastings ... to retain a greater portion of their settlement or ... providing a positive solution for Arizona car accident victims ...
(Date:8/30/2014)... "My niece developed a nighttime fever, and I ... fever might get worse," said an inventor from Montgomery, ... how she was doing, I developed this monitoring system." ... a child's temperature. The unit instantly alerts parents if ... medical care can be given, which is designed to ...
(Date:8/30/2014)... "I had a handicapped friend who could not walk along ... Wetumpka, Ala. "In order to help her be able to ... up with a way for her to use her crutches ... patent-pending Deezers to allow crutches to be used on uneven ... or canes at the beach. The device reduces the risk ...
(Date:8/30/2014)... WA (PRWEB) August 30, 2014 One of ... this era is the gluten-free diet. Originally meant for sufferers ... become a catchall for people who are looking to get ... However, not only is this kind of information erroneous, it ... health problems because of a drastic change in their ...
Breaking Medicine News(10 mins):Health News:Sleepless Nights, Exhausting Days, Mental Fog – Relief for Insomnia With Clinical Psychologist Dr. Carol Francis 2Health News:Hastings and Hastings Is Pleased To Report Having Saved A Client $67,100 On A Settlement Of $610,000 2Health News:“What is Gluten: Three Things You Need to Know Before Adopting a Gluten-Free Diet” Reveals What Readers Need to Know About the Benefits of a Strict Gluten Diet - Vinamy 2
... Unique off-label marketing case results in $425M ... government,s investigation,into Cephalon Inc.,s illegal marketing practices ... plea by the pharmaceutical company began,in January ... Ohio., The sales representative, Bruce Boise, ...
... Bear Bryant,Awards committee of the American Heart Association has ... has been named the,2009 winner of its, Lifetime Achievement ... Award at the Paul Bear,Bryant College Football Coaching Awards ... in Houston. The award recognizes excellence in,coaching on and ...
... pharmacy chain Walgreens has paid the United ... resolve allegations of falsely billing,the Medicaid program, ... submitted claims to Medicaid agencies in four ... both by Medicaid and by,private third-party insurance. ...
... More and more cancer patients are,looking for treatment ... of,life during difficult treatment regimens., ... at:, http://media.medialink.com/WebNR.aspx?story=35774 ) Philips Research is developing ... the effectiveness and reduce the side,effects of chemotherapy ...
... study also finds too many clinicians still using ... -- In children and teens, individual and group ... stress disorder (PTSD) and other trauma symptoms, say ... studies on the subject. , However, despite the ...
... it a “carrier of choice” for many in the medical device ... ... -- All medical devices share a critical need regardless of their ... the supply chain. For medical devices traveling to cross border ...
Cached Medicine News:Health News:Ohio Sales Rep's Information Launched Massive Government Investigation of Cephalon 2Health News:Ohio Sales Rep's Information Launched Massive Government Investigation of Cephalon 3Health News:Ohio Sales Rep's Information Launched Massive Government Investigation of Cephalon 4Health News:Barry Switzer to Receive Paul 'Bear' Bryant Lifetime Achievement Award 2Health News:Walgreens Pays U.S. $9.9 Million to Settle Medicaid Prescription Drug Allegations 2Health News:Cognitive Behavioral Therapy Best for Traumatized Youths 2Health News:Medical Device Producers Express Interest in Purolator USA's Express Service and Customer Service 2
(Date:8/29/2014)... -- Research and Markets has announced the ... & Pipeline Insight 2014" report to their offering. ... and eradicate the prevalence of cancer have achieved limited ... low specificity, safety and large number of side effects, ... solution. It has been discovered that peptides can be ...
(Date:8/29/2014)... Aug. 29, 2014 Does your doctor know what ... doctors have recommended marijuana to the over 112,000 currently registered ... the majority of the other roughly 20,300+ active physicians listed ... little about it – even though a poll in February ... say they have tried it. "With marijuana ...
(Date:8/29/2014)... Corporation , a neurodiagnostics medical device company based in ... Forcht Dagi , MD, DmedSc, MPH, MBA, FACS, FRCSEd  was ... " Teo Forcht Dagi is an experienced leader with ... said Remis Bistras , President and CEO of Vittamed. ... entrepreneurial expertise to our Board." Dr. Dagi is ...
Breaking Medicine Technology:Global Peptide Cancer Therapeutics Market & Pipeline Insight 2014 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 3Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 4Vittamed Adds Prominent Neurosurgeon and Venture Capitalist T. Forcht Dagi to Board of Directors 2
... Nov. 22, 2011  Colorado Drug Card, in partnership with ... has agreed to be the "Preferred Pharmacy" for the ... to process prescriptions through Colorado Drug Card. Coloradans can ... pharmacist to process their prescription through the Colorado Drug ...
... Nov. 22, 2011 Omeros Corporation (NASDAQ: ... to discovering, developing and commercializing products targeting inflammation, ... today announced that Gregory A. Demopulos, M.D., chairman ... at the 23rd Annual Piper Jaffray Health Care ...
Cached Medicine Technology:
14 mm oval solid lower plate and straight 9 mm serrated upper jaw. Locking thumb screw and serrated handle with polished finish....
Oval solid 17 mm wide lower plate. Open upper plate with inside dimensions 12 mm x 14 mm. Serrated handle with locking thumb screw and polished finish. Most popular size or model....
Utrata-like fine angled tips with gently curved shaft for performing capsulorhexis through tunnel incisions. Dull finish. Round handle manufactured in titanium....
McPherson handle. 45 degree angled shafts. Manufactured in titanium....
Medicine Products: