Navigation Links
Silenced genes as a warning sign of blood cancer
Date:8/4/2009

for humans. If so, an early methylation test in high-risk individuals could provide clues about a developing cancer," Christoph Plass says. In this case, preventive medical intervention might be possible. Drugs preventing methyl group attachment might delay the onset of cancer. First clinical studies have already been started to check this. "This is probably most effective in a very early phase of methylation," Plass explains. The researchers believe that the first chemically deactivated genes trigger whole cascades of changes in the genetic material which can hardly be controlled at a later stage.

Keyword: Epigenetics

The cells of the roughly 200 different tissues of the human body can fulfill their special tasks only by regulating the activity of their respective genes very specifically. Although every single gene is equipped with its own control elements, this is not enough for complex coordination. There is a second code that serves as an additional control level. In addition to the genetic switches that are directly integrated in the genetic material, the DNA, genes can also be switched on or off by chemical labeling of the DNA or the DNA packaging proteins. The most common of such epigenetic mutations is the attachment of methyl groups. The effect of these small chemical compounds is that a gene can no longer be read and translated into proteins.

Unlike genetic mutations, which permanently change the sequence of the DNA building blocks, all epigenetic mutations are reversible and, therefore, potential target structures of appropriate drugs.


'/>"/>

Contact: Dr. Sibylle Kohlstaedt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Pathway links inflammation, angiogenesis and breast cancer
2. Traffic Fumes Plus Genes Boosts Kids Asthma Risk
3. New Database to Help Speed Search for Bipolar Disorder Genes
4. Is Perfect Pitch All in the Genes?
5. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
6. Genes Boost Risk for Rheumatoid Arthritis, Lupus
7. The genes involved in rheumatoid arthritis identified
8. If you think cancer genes are simple, you dont know JAK
9. Test for lung cancer looks for discomforting quiet among protective genes
10. Hushed Genes Might Mean Higher Lung Cancer Risk
11. EURYI project to understand how the brain wires during embryogenesis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Dr. Myo Nwe is the co-author of a ... Future” and co-founder of the Ace Medical Weight Loss Center ... a broad look at the industry of weight loss, and ... On film and in television shows, however, she says the ... aspects and played for basic laughs, which she believes impacts ...
(Date:12/17/2014)... HeartMath® Inc., recognized as one of the ... (HRV), heart coherence and the physiology of emotions, ... algorithms to chipset manufacturers and consumer electronics companies. ... offer its HRV solutions, tap into its HRV ... normative HRV databases and algorithms for developing consumer ...
(Date:12/17/2014)... No matter how far modern medicine ... the head louse parasite—a common childhood malady and a ... between six and twelve million individuals will suffer an ... treatment company comes to the rescue, providing an all-natural ... its track record of customer service, and effectiveness in ...
(Date:12/17/2014)... 2014 (HealthDay News) -- As gas prices rose in ... new study suggests. In times of gas increases, ... riders are inexperienced, the researchers explained. They examined ... has the highest number of motorcycle registrations in the ... deaths. The analysis revealed a strong association between ...
(Date:12/17/2014)... Dec. 16, 2014 (HealthDay News) -- Poor students get more ... a new study finds. But, the opposite is true ... having fruits and vegetables at school may give a healthy ... But, no matter what the family income level, students all ... the study found. The study was published recently in ...
Breaking Medicine News(10 mins):Health News:Obesity Should Not Be a Hollywood Punchline, Weight Loss Doc Says 2Health News:HeartMath® Inc.’s HRV Platform Solutions Available for Licensing 2Health News:HeartMath® Inc.’s HRV Platform Solutions Available for Licensing 3Health News:Lice Troopers Announces New Lice Treatment Clinic in Coral Gables to Service Key Biscayne, Coconut Grove, Kendall, Brickell & South Miami 2Health News:When Gas Prices Go Up, So Do Motorcycle Accidents, Study Finds 2Health News:Poor Students Eat Healthier Foods at School, Study Finds 2
... boost emotional well-being in hard times , , THURSDAY, May ... women may actually overspend to try to cheer themselves up, ... found that 79 percent said they,d go on a shopping ... listed "depression" and 60 percent listed "feeling a bit low" ...
... to Improve CBO Modeling and Information for PolicymakersWASHINGTON, ... Fight Chronic Disease policy briefing on Capitol Hill, ... James C. Capretta, M.A., released a white paper, ... Diseases: The Current Context and Potential Enhancements." ...
... Hospitalist Company, Inc. (Nasdaq: IPCM ), a leading national physician group practice company, announced today that management ... New York City., ... ... ...
... CITY, Calif., May 21 Genomic Health, Inc. (Nasdaq: ... will present results from three studies at the American ... May 29 - June 2, 2009, at the Orange ... markets the widely-adopted Onco type DX(R) breast cancer ...
... 21 Celator Pharmaceuticals today announced that it ... Inc. (Nasdaq: CEPH ). The ... application of Celator,s proprietary technology to an ongoing ... agreement provides an opportunity to leverage the technology ...
... the importance of hearing healthPISCATAWAY, N.J., May 21 ... Hearing Month in Times Square from ... air a 30-second hearing loss awareness video every hour on ... addition, 18 Siemens representatives will be in Times Square and ...
Cached Medicine News:Health News:Shop 'Til You Drop: You May Feel Better 2Health News:National Coalition Hosts Event to Examine Costs Projections for Chronic Diseases 2Health News:National Coalition Hosts Event to Examine Costs Projections for Chronic Diseases 3Health News:IPC The Hospitalist Company, Inc. to Present at Citi's 2009 Healthcare Services Day 2Health News:Genomic Health to Present Multiple New Studies at the American Society of Clinical Oncology Annual Meeting 2Health News:Genomic Health to Present Multiple New Studies at the American Society of Clinical Oncology Annual Meeting 3Health News:Celator(R) Pharmaceuticals Initiates Research Agreement With Cephalon, Inc. 2Health News:Siemens Promotes May is Better Speech and Hearing Month on America's Largest Stage 2Health News:Siemens Promotes May is Better Speech and Hearing Month on America's Largest Stage 3
(Date:12/19/2014)... INC. (NYSE: RMD ) today announced that it ... on Thursday, January 22, 2015, after the New York Stock ... be issued after 1:00 p.m. US Pacific Time and the ... future outlook. The earnings call is scheduled to ... webcast of the call can be accessed on ResMed,s Investor ...
(Date:12/19/2014)... 18, 2014   Aratana Therapeutics, Inc . ... focused on the licensing, development and commercialization of ... results from its pivotal field study of AT-001 ... in dogs with osteoarthritis.  In the study, dogs ... that were statistically significant compared to placebo (p<0.05) ...
(Date:12/17/2014)... , Dec. 17, 2014 Royal Philips ... Corporation (NASDAQ: VOLC ), a global leader in ... that they have entered into a definitive merger agreement. Pursuant ... acquire all of the issued and outstanding shares of Volcano ... price of USD 1 billion (approx. EUR 800 million), to ...
Breaking Medicine Technology:ResMed To Announce Second Quarter 2015 Results 2Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 2Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 4Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 5Philips to acquire Volcano to expand global leadership position in image-guided therapy market 2Philips to acquire Volcano to expand global leadership position in image-guided therapy market 3Philips to acquire Volcano to expand global leadership position in image-guided therapy market 4Philips to acquire Volcano to expand global leadership position in image-guided therapy market 5Philips to acquire Volcano to expand global leadership position in image-guided therapy market 6Philips to acquire Volcano to expand global leadership position in image-guided therapy market 7Philips to acquire Volcano to expand global leadership position in image-guided therapy market 8
...
Bimod, acetabular cup "Xl" UHMWHDPE....
Metal on metal hip acetabular cups available for both cemented and cementless applications, the Biomet Merck metal on metal articulation hip system (M2aTM) combines proven materials with the latest i...
S-ROM acetabular cups provide a variety of geometrical options to help address many anatomical situations and defects....
Medicine Products: