Navigation Links
Silenced genes as a warning sign of blood cancer
Date:8/4/2009

for humans. If so, an early methylation test in high-risk individuals could provide clues about a developing cancer," Christoph Plass says. In this case, preventive medical intervention might be possible. Drugs preventing methyl group attachment might delay the onset of cancer. First clinical studies have already been started to check this. "This is probably most effective in a very early phase of methylation," Plass explains. The researchers believe that the first chemically deactivated genes trigger whole cascades of changes in the genetic material which can hardly be controlled at a later stage.

Keyword: Epigenetics

The cells of the roughly 200 different tissues of the human body can fulfill their special tasks only by regulating the activity of their respective genes very specifically. Although every single gene is equipped with its own control elements, this is not enough for complex coordination. There is a second code that serves as an additional control level. In addition to the genetic switches that are directly integrated in the genetic material, the DNA, genes can also be switched on or off by chemical labeling of the DNA or the DNA packaging proteins. The most common of such epigenetic mutations is the attachment of methyl groups. The effect of these small chemical compounds is that a gene can no longer be read and translated into proteins.

Unlike genetic mutations, which permanently change the sequence of the DNA building blocks, all epigenetic mutations are reversible and, therefore, potential target structures of appropriate drugs.


'/>"/>

Contact: Dr. Sibylle Kohlstaedt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Pathway links inflammation, angiogenesis and breast cancer
2. Traffic Fumes Plus Genes Boosts Kids Asthma Risk
3. New Database to Help Speed Search for Bipolar Disorder Genes
4. Is Perfect Pitch All in the Genes?
5. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
6. Genes Boost Risk for Rheumatoid Arthritis, Lupus
7. The genes involved in rheumatoid arthritis identified
8. If you think cancer genes are simple, you dont know JAK
9. Test for lung cancer looks for discomforting quiet among protective genes
10. Hushed Genes Might Mean Higher Lung Cancer Risk
11. EURYI project to understand how the brain wires during embryogenesis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2015)... Aidan Booth And Steve Clayton's ... yesterday, and has since received rave reviews from ... Tiffany Hendricks has weighed in with her opinion ... on her website HonestyFirstReviews.com. , "These days the ... looking to hone their business skills has gotten ...
(Date:6/2/2015)... (PRWEB) June 02, 2015 Food Lion ... its sixth annual “Thriller on the Griller” events, starting ... and South Carolina locations. Each event will raise funds ... to restoring a sense of self, restoring the family ... our military families. , Through these events, Food ...
(Date:6/2/2015)... (PRWEB) June 02, 2015 MEDIA ... Wallace, 571-319-9594 (cell) , Email: ewallace(at)mentalhealthamerica(dot)net , Breaking ... New Mental Health Legislation at MHA Annual Conference ... What: Rep. Murphy to address the Mental Health ... the long-awaited updated version of the Helping Families ...
(Date:6/2/2015)... April 8th, 2015, saw the transformation ... Entertainment’s “RockNRolla Movie Awards” EcoLuxe Lounge, a daylong event, ... of the world’s top providers of ecologically sound and ... by Debbie Durkin, Los Angeles’ leading producer of sustainable ... is a premier red carpet event that makes appearances ...
(Date:6/2/2015)... 2015 On March 19th, 2015, LiveToBeSober.org ... the Hall of Legends at Detroit’s Ford Field. Hosted ... Herman Moore, the goal of the conference was to ... society, highlight the benefits of effective professional rehabilitation programs. ... the options that are available to them in regards ...
Breaking Medicine News(10 mins):Health News:100K Factory - Review of Aidan Booth and Steve Clayton's New IM System Published 2Health News:Food Lion to Launch “Thriller on the Griller” Events to Benefit Military Families through Hope For The Warriors® 2Health News:Food Lion to Launch “Thriller on the Griller” Events to Benefit Military Families through Hope For The Warriors® 3Health News:Congressman Tim Murphy to Unveil Details of New Mental Health Legislation at MHA Annual Conference Thursday 2Health News:Choices Recovery South Bend Discusses Addiction With Rising Hollywood Star Ben Stillwell 2Health News:Rehabilitation Facility Graduate Shares Her Story at "Fighting Addiction Together" Conference 2
... teachers and students prefer enhanced sex education programs//, they ... UK schools. When teen pregnancy is taken into consideration, ... officials said. The study, which was conducted by the ... Medical Journal, covered about 25 secondary schools. ...
... of Parliament tuesday that she would resign if the ... by March 2007. ,Her comment was ... select committee who were apprehensive about the NHS's half-year ... NHS trusts are forecasting deficits. The deficits are expected ...
... over the effects of drinking too much alcohol on their ... While alcohol-related deaths have doubled in last 15 years, just ... last 3 months, worried about the effects of over drinking ... exercise and too much stress – says Legal & General. ...
... type of salmonella bacteria.It is usually found in eggs infected ... bacteria is now found more often in chicken meat. Tests ... increase of salmonella enteritidis on chicken meat., ,Salmonella is ... year with an annual death toll of about 600 in ...
... play an important role in how insects develop from ... model for congestive heart failure// to be effective in ... rhythms, according to UC Davis research published in the ... Academy of Sciences. ,The research, led by cardiologist ...
... includes products like insulin, sugar-free food and healthcare books, ... 'D' Lounge has been set up by Way-to-Health, a ... ,"'D' Lounge offers a complete range of products ... biscuits, jams and honey. Sugar-free toothpaste is also available ...
Cached Medicine News:Health News:Insect Protein Effective for Treating Heart Enlargement, Arrythmias 2
(Date:6/2/2015)... -- Vanda Pharmaceuticals Inc. (Vanda) (NASDAQ: VNDA ), a ... products for the treatment of central nervous system disorders, ... Vanda,s President and CEO, will deliver a corporate presentation ... New York City on Thursday, June 4, ... presentation at the Jefferies Global Healthcare Conference will be ...
(Date:6/2/2015)... International plc (NASDAQ: ENDP ) (TSX: ENL) (the ... an underwritten public offering of $1.75 billion of ordinary ... are to be sold by Endo. ... the Offering an option, exercisable for a period of ... supplement, to purchase an additional $262.5 million of ordinary ...
(Date:6/2/2015)... STATESVILLE, N.C. , June 2, 2015 ... its Board of Directors declared a quarterly cash dividend ... 26, 2015 to stockholders of record at the close ... About Kewaunee Scientific Founded in 1906, Kewaunee ... design, manufacture, and installation of laboratory, healthcare, and technical ...
Breaking Medicine Technology:Endo International plc Announces Proposed Public Offering of $1.75 Billion of Ordinary Shares 2Endo International plc Announces Proposed Public Offering of $1.75 Billion of Ordinary Shares 3Endo International plc Announces Proposed Public Offering of $1.75 Billion of Ordinary Shares 4
... BOSTON, Dec. 29, 2011  Solos Endoscopy, Inc. (OTCPK: SNDY) ... continued growth in 2012 through the development and sales ... treatment and management of medical conditions. In 2011, Solos ... approximately $300,000 in debt for the Company. The signed ...
... Dec. 29, 2011 Janssen Research & Development, LLC (JRD) ... Application (sNDA) to the U.S. Food and Drug Administration (FDA) ... an oral anticoagulant, to reduce the risk of (thrombotic) cardiovascular ... The filing is supported by data from the pivotal Phase ...
Cached Medicine Technology:Solos Endoscopy, Inc. is Primed for Growth in 2012 2Solos Endoscopy, Inc. is Primed for Growth in 2012 3Janssen Research & Development Submits Application to U.S. FDA for XARELTO® (rivaroxaban) to Reduce Secondary Cardiovascular Events in Patients with Acute Coronary Syndrome 2Janssen Research & Development Submits Application to U.S. FDA for XARELTO® (rivaroxaban) to Reduce Secondary Cardiovascular Events in Patients with Acute Coronary Syndrome 3Janssen Research & Development Submits Application to U.S. FDA for XARELTO® (rivaroxaban) to Reduce Secondary Cardiovascular Events in Patients with Acute Coronary Syndrome 4Janssen Research & Development Submits Application to U.S. FDA for XARELTO® (rivaroxaban) to Reduce Secondary Cardiovascular Events in Patients with Acute Coronary Syndrome 5Janssen Research & Development Submits Application to U.S. FDA for XARELTO® (rivaroxaban) to Reduce Secondary Cardiovascular Events in Patients with Acute Coronary Syndrome 6Janssen Research & Development Submits Application to U.S. FDA for XARELTO® (rivaroxaban) to Reduce Secondary Cardiovascular Events in Patients with Acute Coronary Syndrome 7Janssen Research & Development Submits Application to U.S. FDA for XARELTO® (rivaroxaban) to Reduce Secondary Cardiovascular Events in Patients with Acute Coronary Syndrome 8Janssen Research & Development Submits Application to U.S. FDA for XARELTO® (rivaroxaban) to Reduce Secondary Cardiovascular Events in Patients with Acute Coronary Syndrome 9Janssen Research & Development Submits Application to U.S. FDA for XARELTO® (rivaroxaban) to Reduce Secondary Cardiovascular Events in Patients with Acute Coronary Syndrome 10Janssen Research & Development Submits Application to U.S. FDA for XARELTO® (rivaroxaban) to Reduce Secondary Cardiovascular Events in Patients with Acute Coronary Syndrome 11
Angled for temporal approach. Solid 14 mm blades. Dull finish....
Open 11 mm blades. Polished finish....
Open 10 mm blades. Dull finish....
Angled for temporal approach. Open 14 mm rounded blades for patient comfort. Dull finish....
Medicine Products: