Navigation Links
Signs of Alzheimer's disease may be present decades before diagnosis
Date:8/11/2008

Tampa, FL (August 11, 2008) Scientists from the University of South Florida and the University of Kentucky report that people who develop Alzheimer's disease may show signs of this illness many decades earlier in life, including compromised educational achievement. Their research appears online this month in the journal Alzheimer's Disease and Associated Disorders.

Participants in the Nun Study were studied to identify those who became demented before death or had characteristic brain changes of Alzheimer's disease at autopsy. Among nuns who became demented or had evidence of Alzheimer's disease at autopsy, those with small head sizes had significantly lower educational achievement in earlier adult life. In those dying without a dementia diagnosis or autopsy evidence of Alzheimer's disease, head size had no relationship with education.

Adult head size can be used to estimate the size of the fully-developed brain. Previous studies have found that clinical expression of Alzheimer's disease is related to head size, with people having smaller heads more likely to show the characteristic symptoms of this illness. Larger brains provide reserve against Alzheimer's, allowing people to function normally despite having considerable Alzheimer pathology in their brains.

"If brain damage related to Alzheimer's disease begins earlier in adult life, then having less reserve due to a smaller brain could compromise intellectual ability in those destined to get Alzheimer's and lead to them getting less education," said lead author James Mortimer, PhD, Professor of Epidemiology at USF. "Although it has been known for many years that individuals with lower education have a greater risk of getting Alzheimer's, this is the first report showing that reduced educational attainment may actually be an early sign of the underlying disease."

The study findings add to others showing that individuals who will eventually develop Alzheimer's differ from those who don't many decades before. In 1996, the Nun Study found that Alzheimer's disease with onset in old age could be predicted accurately from characteristics of autobiographical essays written at an average age of 22. Other studies have shown that those who develop Alzheimer's have specific deficits on tests of memory and thinking decades before the disease is diagnosed. The fact that subtle signs of Alzheimer's appear many years before symptoms appear may be useful for predicting who is at risk of the illness and identifying individuals earlier in life who could benefit from preventive therapies.


'/>"/>

Contact: James Mortimer
jmortime@health.usf.edu
813-857-3163
University of South Florida Health
Source:Eurekalert  

Related medicine news :

1. Mylan Creates New Womens Health Care Franchise; Signs Agreement with Famy Care to Develop and Supply 22 Oral Contraceptive Products
2. China Healthcare Acquisition Corp Signs Definitive Agreement to Acquire Europe Asia Huadu Environment Holding Pte, Ltd.
3. Data mining detects signs of Lou Gehrigs disease in gene carriers long before symptoms appear
4. ACS Signs Five-Year, $100 Million Deal to Provide Technology Services to UMass Memorial Health Care, Inc.
5. DiaLog Signs Agreement with DeliverMed to Improve Diabetic Patient Management
6. Streamline Health(R) Signs Catholic Healthcare West for Integrated Document Workflow Solutions
7. iNutrition Signs John OHurley to Launch New Internet Video Campaign
8. Huntsville Hospital Signs With Health Care Systems, Inc. for Automated Medication Reconciliation Services
9. BMP Sunstone Signs Letter of Intent to Acquire Shengda Pharmaceutical Co.
10. Dilon Technologies Signs Amerinet for Breast-Specific Gamma Imaging
11. Wyeth Consumer Healthcare Signs Agreement to Purchase ThermaCare from Procter & Gamble
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Signs of Alzheimer's disease may be present decades before diagnosis
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of ... Philippines. “The Journey: From the Mountains to the Mission Field” is the creation of ... taught all ages and currently teaches a class of ladies at her church, which ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), ... will showcase a range of technology and learning solutions at the 68th Annual ... Expo to be held October 14–18, 2017 at the Mandalay Bay Resort in ...
(Date:10/12/2017)... New Orleans, LA (PRWEB) , ... October 12, 2017 , ... ... fitness centers in the U.S., announced today its plans to open a flagship location ... club will occupy the former Rooms To Go store next to Office Depot in ...
(Date:10/12/2017)... ... 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one of ... innovative new design of the shoulder pad. The shoulder pad provides optimal support ... your pain while using cold therapy. By utilizing ice and water that is circulated ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... -- AllianceRx Walgreens Prime, the combined central specialty pharmacy and ... manager Prime Therapeutics LLC (Prime), today officially began the ... of new signage at its headquarters in ... few other company-owned facilities across the country. This also ... whom will begin to see the AllianceRx Walgreens Prime ...
(Date:9/28/2017)... 2017 Cohen Veterans Bioscience and Early Signal ... wearable and home sensors for real-time monitoring of patients ... a nonprofit organization focused on disruptive health solutions for ... analytical system to record and integrate behavioral, cognitive, physiological ... ...
(Date:9/25/2017)...  EpiVax, Inc., a leader in the fields ... announced the launch of EpiVax Oncology Inc., a ... cancer vaccines. EpiVax has provided $500,000 in seed ... technologies to the new precision immunotherapy venture. Gad ... as Chief Executive Officer. Gad brings over 25 ...
Breaking Medicine Technology: