Navigation Links
Signs of Alzheimer's disease may be present decades before diagnosis
Date:8/11/2008

Tampa, FL (August 11, 2008) Scientists from the University of South Florida and the University of Kentucky report that people who develop Alzheimer's disease may show signs of this illness many decades earlier in life, including compromised educational achievement. Their research appears online this month in the journal Alzheimer's Disease and Associated Disorders.

Participants in the Nun Study were studied to identify those who became demented before death or had characteristic brain changes of Alzheimer's disease at autopsy. Among nuns who became demented or had evidence of Alzheimer's disease at autopsy, those with small head sizes had significantly lower educational achievement in earlier adult life. In those dying without a dementia diagnosis or autopsy evidence of Alzheimer's disease, head size had no relationship with education.

Adult head size can be used to estimate the size of the fully-developed brain. Previous studies have found that clinical expression of Alzheimer's disease is related to head size, with people having smaller heads more likely to show the characteristic symptoms of this illness. Larger brains provide reserve against Alzheimer's, allowing people to function normally despite having considerable Alzheimer pathology in their brains.

"If brain damage related to Alzheimer's disease begins earlier in adult life, then having less reserve due to a smaller brain could compromise intellectual ability in those destined to get Alzheimer's and lead to them getting less education," said lead author James Mortimer, PhD, Professor of Epidemiology at USF. "Although it has been known for many years that individuals with lower education have a greater risk of getting Alzheimer's, this is the first report showing that reduced educational attainment may actually be an early sign of the underlying disease."

The study findings add to others showing that individuals who will eventually develop Alzheimer's differ from those who don't many decades before. In 1996, the Nun Study found that Alzheimer's disease with onset in old age could be predicted accurately from characteristics of autobiographical essays written at an average age of 22. Other studies have shown that those who develop Alzheimer's have specific deficits on tests of memory and thinking decades before the disease is diagnosed. The fact that subtle signs of Alzheimer's appear many years before symptoms appear may be useful for predicting who is at risk of the illness and identifying individuals earlier in life who could benefit from preventive therapies.


'/>"/>

Contact: James Mortimer
jmortime@health.usf.edu
813-857-3163
University of South Florida Health
Source:Eurekalert  

Related medicine news :

1. Mylan Creates New Womens Health Care Franchise; Signs Agreement with Famy Care to Develop and Supply 22 Oral Contraceptive Products
2. China Healthcare Acquisition Corp Signs Definitive Agreement to Acquire Europe Asia Huadu Environment Holding Pte, Ltd.
3. Data mining detects signs of Lou Gehrigs disease in gene carriers long before symptoms appear
4. ACS Signs Five-Year, $100 Million Deal to Provide Technology Services to UMass Memorial Health Care, Inc.
5. DiaLog Signs Agreement with DeliverMed to Improve Diabetic Patient Management
6. Streamline Health(R) Signs Catholic Healthcare West for Integrated Document Workflow Solutions
7. iNutrition Signs John OHurley to Launch New Internet Video Campaign
8. Huntsville Hospital Signs With Health Care Systems, Inc. for Automated Medication Reconciliation Services
9. BMP Sunstone Signs Letter of Intent to Acquire Shengda Pharmaceutical Co.
10. Dilon Technologies Signs Amerinet for Breast-Specific Gamma Imaging
11. Wyeth Consumer Healthcare Signs Agreement to Purchase ThermaCare from Procter & Gamble
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Signs of Alzheimer's disease may be present decades before diagnosis
(Date:5/2/2016)... ... May 02, 2016 , ... “Engineering Bubbles,” an oil painting submitted by Canadian ... Forum held recently at the Annual Meeting in Los Angeles. The first annual art ... members and Annual Meeting attendees. , “Through art I hope to educate people ...
(Date:5/2/2016)... ... May 02, 2016 , ... WestHarbor Growth Partners, ... today the release of Grow Healthy Vending’s newly revamped brand campaign. Grow ... growing healthy vending providers in North America with locations across the United States ...
(Date:5/2/2016)... ... 2016 , ... East Los Angeles dentist , Dr. Ramin Assili, is ... to receive any dental extraction treatment for $40 off the regular price. This promotion ... the lower price, patients can more easily afford extractions to eliminate teeth that are ...
(Date:5/2/2016)... , ... May 02, 2016 , ... Further establishing itself ... announce that the new WHIMZEES Variety Value Boxes were selected from over 1,000 entrants ... Showcase Award. , WHIMZEES natural dental chews for dogs are a favorite product ...
(Date:5/2/2016)... , ... May 02, 2016 , ... ... itself around major organs, such as the kidneys, liver and pancreas. If not ... M.D ., a board-certified physician in Internal Medicine, Medical Oncology and Palliative Care, ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... MARLBOROUGH, Mass. , May 2, 2016  While ... effects that osteoporosis can have on their health, only ... 1   according to the results of a new ... ). To mark the start of National Osteoporosis Month, ... women,s health, which affects nearly 56 million Americans. ...
(Date:5/2/2016)... , May 2, 2016 ... to reach USD 11.1 billion by 2024, according ... Research, Inc. Major drivers of the sonography market ... areas and government recommendations for periodic ultrasound screenings ...      (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) ...
(Date:4/29/2016)... April 29, 2016 ReportsnReports.com ... 2016" market research report that provides an overview ... analysis at various stages, therapeutics assessment by drug ... (RoA) and molecule type, along with latest updates, ... reviews key players involved in the therapeutic development ...
Breaking Medicine Technology: