Navigation Links
Significantly higher success rates with artificial insemination
Date:2/6/2008

This release is also available in German.

In future a new method could help some couples who are childless against their will. The microscopic procedure significantly improves the success rate of 'ICSI' (intracytoplasmic sperm injection). This was discovered by scientists at the University of Bonn together with colleagues from China and industrial partners in a study of 124 women. Up to now, the desire to have a child is only fulfilled for every third couple that decides to have ICSI. In a study the artificial insemination method was twice as successful. The scientists have now published their data in the journal 'Reproductive BioMedicine'. (Online version available at http://www.rbmonline.com/Article/3161).

For many couples ICSI is the last resort in their attempt to have a child. 'The method is recommended if the man produces too few sperm cells,' the Bonn reproductive biologist Dr. Markus Montag explains. Doctors can in most cases still extract individual functioning sperm cells from testicular tissue, which they then inject into the ovum. The partner must take hormone preparations before an ICSI. They result in several ova maturing in the ovaries, normally it is only one ovum per month.

'We inject a sperm into every one of these cells,' Markus Montag explains. 'Then it takes more than 26 hours until the plasmosomes of the ovum and sperm cell fuse and an embryo forms. In this time frame we have to decide which of the fertilised ova to insert into the uterus. The reason for this is that the German law for the protection of embryos lays down that only a maximum of three fertilised ova are allowed to be implanted per attempt. 'We even restrict ourselves to only two, in order to exclude the possibility of births of triplets,' Markus Montag explains. With pregnancies involving multiple births there is an increased risk of miscarriages and malformations.

Choosing the 'best' ova

Which of the fertilised ova are finally implanted has usually been left up to chance. But today it is known that not all ova have the same quality. Using a special procedure the Bonn scientists can select the two most suitable candidates. 'For this we observe the ovule integument under a DIC microscope,' Dr. Montag explains. 'There it appears as a luminescent orange-red ring. The brighter this ring is and the more uniformly it shines, the greater the chance that it becomes a child.' The reason for this is that the ovule integument always seems to have a particularly uniform structure if the cell has matured under good conditions.

Normally every third ICSI is successful. But if medics used two 'good ' ova in their experiment, this rate increased to more than 50 per cent. With a 'good' and a 'bad' ovum the success rate was still around 40 per cent, using two 'bad' ones only 20 per cent. 'Mind you, two good ova are rare,' Markus Montag emphasises. 'Only with two out of ten cells does the ovule integument have an intense regular orange colour.'

Under natural conditions insemination takes place in the oviduct. After that the ovum begins to divide, while contractions of the oviduct transport it to the uterus. This process takes just under 2-3 days. When the embryo lodges in the endometrium on the sixth day after insemination, the embryo consists of several hundred cells. During the whole process the embryo is protected by the ovule integument.

The Bonn team led by Dr. Markus Montag and Professor Hans van der Ven has developed software in conjunction with the Octax Microscience Company, which analyses the image from the microscope objectively and proposes the most suitable cells. 'This way the procedure can be implemented in clinical routine without problems and without much effort,' he says.


'/>"/>

Contact: Markus Montag
Markus.Montag@ukb.uni-bonn.de
49-022-828-715-449
University of Bonn
Source:Eurekalert

Related medicine news :

1. New findings show Enbrel significantly reduced levels of C-reactive protein
2. Canadian Marketing and Sales Effort for Labopharms Once-Daily Tramadol Product to Expand Significantly
3. Drug-based on MGH discovery may significantly improve treatment of dangerous blood disorder
4. Breast cancer risk varies significantly among BRCA1 and BRCA2 carriers
5. Tonsillectomy significantly improves quality of life in adult and pediatric patients
6. Adult ADHD significantly impacts on social, financial and personal aspects of life
7. Transports Phase 2 Data Show Single Treatment SoloVir(TM) ETS Significantly Stops Progression of Cold Sore Episode
8. PET imaging significantly enhances standard imaging in lung cancer staging
9. Millennium Announces MLN1202 Significantly Reduced Marker of Systemic Inflammation and Identifies Genomic Biomarker For Responders
10. Ranexa(R) Significantly Reduces Ischemia in Women in MERLIN TIMI-36 Study
11. Ranexa(R) Significantly Reduces Incidence of CV Death, MI or Recurrent Ischemia in MERLIN TIMI-36 Patients With Elevated BNP
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ... certification process to promote standards of excellence for the field of eating disorders, ... March 22 – 25, 2018 in Orlando, Florida at the Omni Resort at ...
(Date:10/13/2017)... ... October 13, 2017 , ... Southern ... and Jennifer Huggins, PharmD ’17, along with clinical associate professor Janice Frueh, ... cardiovascular diseases during the 15th Annual Women’s Health Conference. The SIU School ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes ... a mock evacuation of the facility as part of a disaster drill on October ... Hose EMS and Shelton City Emergency Manager, as well as the Connecticut Long ...
(Date:10/13/2017)... , ... October 13, 2017 , ... The Visiting Nurse ... Market. Featuring a collection of specialty vendors and unique items from across the nation, ... quality-focused health and wellness services offered by the VNA. The boutique will be ...
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids this ... by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited about ... ages; it is a non-competitive, non-timed event, which is all about having fun and ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., ... vaccine design, and immune-engineering today announced the launch ... the development of personalized therapeutic cancer vaccines. EpiVax ... provided exclusive access to enabling technologies to the ... MBA will lead EpiVax Oncology as Chief Executive ...
(Date:9/22/2017)... AVACEN Medical (AVACEN) announced that its CE-Marked ... those with the widespread pain associated with fibromyalgia in ... Essex, England commented, "I had ... no sleep at all, tremendous pain, with every movement ... [the AVACEN 100] enough, how this has and is ...
(Date:9/18/2017)... Mich. , Sept. 18, 2017  PMD Healthcare ... Specialty Pharmacy of Kalamazoo, Mich. , ... hub service that expedites and streamlines patient and provider ... PD 2.0, and wellness management services.  ... device used to measure lung function for a variety ...
Breaking Medicine Technology: