Navigation Links
Signals found that recruit host animals' cells, enabling breast cancer metastasis
Date:5/22/2014

mong breast cancer cells, menenchymal stem cells and white blood cells. One positive feedback loop brought mesenchymal stem cells close in to the breast cancer cells. A separate loop of signals between the stem cells and cancer cells caused the cancer cells to release a chemical "beacon" that drew in white blood cells. The concentrations of all the signals in the web were increased by the presence of HIF-1 and ultimately, by low-oxygen conditions.

The team then used genetic engineering to reduce the levels of the cell-recruiting signals in breast cancer cells and implanted those cells into female mice. Compared with unaltered breast cancer cells, those with reduced recruiting power grew into similar-sized tumors, Semenza says, but were much less likely to spread.

All of the breast cancer cells used in the study were so-called triple-negative, meaning they lack receptors for estrogen, progesterone and human epidermal growth factor receptor 2, so they do not respond to therapies that target those receptors. In people, triple-negative breast cancers also tend to be more deadly than other breast cancers because they contain more HIF-1, Semenza says. "This study adds to the evidence that a HIF-1 inhibitor drug could be an effective addition to chemotherapy regimens, especially for triple-negative breast cancers," he says. Several potential drugs of this kind are now in the early stages of development, he notes.


'/>"/>

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Molecular aberration signals cancer
2. Tinnitus study signals advance in understanding link between loud sounds exposure and hearing loss
3. Long distance signals protect brain from viral infections
4. BioPharm Systems to Host Webinar on Evaluating and Investigating Drug Safety Signals with Public Databases
5. Protein in prostate biopsies signals increased cancer risk
6. Pleasure and pain brain signals disrupted in fibromyalgia patients
7. Disney researchers use encoded audio signals to provide second screen experiences at most venues
8. Self-perpetuating signals may drive tumor cells to spread
9. One Million Babies Born HIV-free Signals Major Milestone in Global Effort to Eliminate Pediatric AIDS
10. Turning Alzheimers fuzzy signals into high definition
11. Autism Speaks trailblazer study -- Blocking cell distress signals can ease autism symptoms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/3/2015)... , ... September 03, 2015 , ... ... Scholarship applications are open for spring 2016. Scholarships are awarded two times each ... For The Warriors® is a national nonprofit dedicated to restoring a sense of ...
(Date:9/3/2015)... ... September 03, 2015 , ... ... landscape by connecting accredited and institutional investors to real estate investment opportunities nationwide, ... to meet demand from both investors and sponsoring real estate companies. ...
(Date:9/3/2015)... ... September 03, 2015 , ... The Linda Hall Library 2015 ... a comet, the IceCube observatory at the South Pole, and the interior of life-extending ... Lecture Series for the world's foremost independently funded research library devoted to science, engineering, ...
(Date:9/3/2015)... , ... September 03, 2015 , ... Dr. Robert Winchell ... Trauma, Burns, Critical and Acute Care at NewYork-Presbyterian/Weill Cornell Medical Center, effective July 27. ... is a nationally renowned expert in care for the critically injured and the development, ...
(Date:9/3/2015)... ... 2015 , ... Atlantic Information Services, Inc. (AIS) is pleased ... for a Rapidly Changing Marketplace.” In this Sept. 16 program, pharmacy benefit experts ... plan sponsors are adopting bold, innovative strategies to control soaring specialty pharmacy and ...
Breaking Medicine News(10 mins):Health News:Hope For The Warriors Spouse/Caregiver Scholarships Now Open for Spring 2016 2Health News:RealtyShares Announces Mezzanine Financing Products 2Health News:RealtyShares Announces Mezzanine Financing Products 3Health News:Facing the Frontiers of Science and Technology The Linda Hall Library Announces 2015 Fall Lecture Series Featuring Experiences from the South Pole to Outer Space 2Health News:Facing the Frontiers of Science and Technology The Linda Hall Library Announces 2015 Fall Lecture Series Featuring Experiences from the South Pole to Outer Space 3Health News:Facing the Frontiers of Science and Technology The Linda Hall Library Announces 2015 Fall Lecture Series Featuring Experiences from the South Pole to Outer Space 4Health News:Facing the Frontiers of Science and Technology The Linda Hall Library Announces 2015 Fall Lecture Series Featuring Experiences from the South Pole to Outer Space 5Health News:Trauma Expert Joins NewYork-Presbyterian Hospital and Weill Cornell Medical College 2Health News:Trauma Expert Joins NewYork-Presbyterian Hospital and Weill Cornell Medical College 3Health News:Trauma Expert Joins NewYork-Presbyterian Hospital and Weill Cornell Medical College 4Health News:Trauma Expert Joins NewYork-Presbyterian Hospital and Weill Cornell Medical College 5Health News:Speakers for Upcoming AIS Virtual Conference on Pharmacy Benefit Strategies Include Executives from CVS Health, Express Scripts 2
... most humans couldn,t maintain such a low-cal diet, scientists ... back drastically on daily calorie intake can lead to ... Buffalo researchers. , They speculate that this kind of ... slowing the progression to disability. , A lifelong 40 ...
... Palatin Technologies,Inc. (Amex: PTN ) today announced ... Renshaw 9th Annual Healthcare Conference at the New York ... at 4:45 PM ET. Carl Spana, Ph.D., President ... update on the Company,s corporate and,development programs. To access ...
... effective in patients under 60, study finds , FRIDAY, Nov. ... are just as effective for treating prostate cancer in men ... new study finds. , Brachytherapy is a minimally invasive ... prostate to kill cancer cells. Recovery time after seed implantation ...
... honor Hispanic entrepreneurs in ... Texas with Aflac Civic Awards., ... recognized with an Aflac Civic Award for making a,difference in ... Barreto, chairman of the Latino Coalition and former,administrator of the ...
... Nov. 2 National Infertility Awareness Week is,Nov. 4-10. ... affects one in eight couples in the United States. ... a male or a female,which inhibits the ability to ... inability to conceive after one year of trying with ...
... ... and Long-Term Health, SAN FRANCISCO, ... food products that their scientific evidence and clinical,benefits may often ... clinicians, said presenters at a satellite,symposium during the 2007 meeting ...
Cached Medicine News:Health News:Calorie-Starved Rats Live Longer: Study 2Health News:Radiation Seed Treatment Helps Younger Men Fight Prostate Cancer 2Health News:Aflac Honors Hispanic Entrepreneurs Making a Difference in Texas 2Health News:Aflac Honors Hispanic Entrepreneurs Making a Difference in Texas 3Health News:Aflac Honors Hispanic Entrepreneurs Making a Difference in Texas 4Health News:Updated: National Infertility Awareness Week Nov. 4-10; Infertility Affects Significant Number of Couples 2Health News:Updated: National Infertility Awareness Week Nov. 4-10; Infertility Affects Significant Number of Couples 3Health News:Probiotics Play Critical Role in Pediatric Health and Immunity 2Health News:Probiotics Play Critical Role in Pediatric Health and Immunity 3
(Date:9/3/2015)...  VirtualScopics, Inc. (NASDAQ: VSCP ), a ... today, they are collaborating with a large pharmaceutical ... study partnering with the Ministry of Health in ... up with a cardiac sonographer to acquire echocardiograms ... be used to identify children with rheumatic heart ...
(Date:9/3/2015)... , Sept. 3, 2015 Research ... addition of the "Investigation Report on China,s ... Thyroid hormones (TH) have the ... or younger ones. Without thyroid hormones mainly promote ... reproductive organs, even the growth hormone (GH) of ...
(Date:9/3/2015)...  CVS Health Corporation (NYSE: CVS ) today ... and chief executive officer, and Dave Denton , ... speaking to investors at the Morgan Stanley 2015 Global ... to speak at approximately 8:00 a.m. (EDT). ... simultaneously through the Investor Relations portion of the CVS ...
Breaking Medicine Technology:VirtualScopics, Inc. Collaborates with Large Pharmaceutical Company on a Philanthropic, Epidemiology Study in Africa 2VirtualScopics, Inc. Collaborates with Large Pharmaceutical Company on a Philanthropic, Epidemiology Study in Africa 3VirtualScopics, Inc. Collaborates with Large Pharmaceutical Company on a Philanthropic, Epidemiology Study in Africa 4Investigation Report on China's Levothyroxine Market, 2010-2019 2
... , BIRMINGHAM, Ala. and NOIDA, India, ... Birmingham (UAB), and Southern Research Institute today announced a joint ... enabling technologies in the areas of Oncology, Metabolic Disease and ... partnership that will accelerate the development of affordable therapies for ...
... , EXTON, Pa., Nov. 23 BioTrends Research ... (TM): Feraheme report, the second in a ... IV iron product, Feraheme, through the first six months of product ... 50 unique Nephrologists and qualitative information from a subset of 15. ...
Cached Medicine Technology:Jubilant Organosys, UAB and Southern Research Enter Into Drug Discovery Joint Venture 2Jubilant Organosys, UAB and Southern Research Enter Into Drug Discovery Joint Venture 3Jubilant Organosys, UAB and Southern Research Enter Into Drug Discovery Joint Venture 4Reported Use of AMAG's Feraheme (ferumoxytol) Continues To Be Low, But a Number of Nephrologists Are 'On the Verge' of Use 2
The workhorse electric system....
... BD Xstar Blade includes a specially designed, ... in prodedure and handling. The Xstar ... process for manufacturing surgical blades. This ... The arch style, single-bevel geometry allows ...
... The BD Safety Knife with BD ... retractable shield that protects the blade in ... technology is based on a grind-less process ... process yields outstanding sharpness and consistency. ...
... BD Xstar Blade includes a specially designed, ... in prodedure and handling. The Xstar ... process for manufacturing surgical blades. This ... The arch style, single-bevel geometry allows ...
Medicine Products: