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Signaling protein helps limit damage in heart attack, Jefferson scientists show
Date:3/21/2008

, Gi is an important protective mechanism, Dr. Koch says. The heart wants to activate Gi and attempt to protect cardiac myocytes from dying. We found that in this acute setting, heart attacks are bigger when Gi is blocked. As a result, the heart cant pump as well.

They would like to find out Gis role in chronic heart failure, where there is much less cell death occurring, and Gi levels remain high. In the chronic phase, Dr. Koch points out, Gi activity could be maladaptive. They plan to test the idea in chronic heart failure animal models.


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Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

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