Navigation Links
Signaling protein helps limit damage in heart attack, Jefferson scientists show

(PHILADELPHIA) Scientists at the Center for Translational Medicine at Thomas Jefferson University in Philadelphia have shown that a specific signaling protein is crucial to protecting the heart and helping it to adapt during a heart attack.

The protein Gi is known to have increased activity in the failing heart, but researchers have never been sure if it was helping the heart adapt to damage or if it was actually causing more heart cells to die. The Jefferson team, led by Walter Koch, Ph.D., W.W. Smith Professor of Medicine and director of the Center for Translational Medicine in the Department of Medicine at Jefferson Medical College, experimentally blocked the protein in the hearts of genetically engineered mice experiencing heart attacks. They found that the animals had greater heart damage than did similar mice with a working protein. The team reports its findings March 18, 2008, in the journal Circulation.

Gi is important in intracellular signaling, akin to a molecular switch, Dr. Koch notes. Its not a new drug target, he explains, but the activation of some receptors (such as beta-2 adrenergic receptors) that also turn on Gi could be targets.

Developing a class-specific Gi inhibitor, Dr. Koch explains, is an important step to understanding Gis role and behavior. We dont have to worry about what receptor we are blocking; were blocking a receptor that couples with Gi. We never had the tools before to tell if Gi activation was good or bad. We think that we can now begin to test the role of Gi in cardiac injury.

In the work, Dr. Kochs group developed a transgenic mouse with a functional knockout of the Gi gene, meaning that it lacked a working gene. The scientists then simulated a heart attack, catheterization and reperfusion by tieing off a coronary artery for 30 minutes and subsequently reestablishing the blood flow, causing an inflammatory response and tissue damage.

It appears that in this setting, Gi is an important protective mechanism, Dr. Koch says. The heart wants to activate Gi and attempt to protect cardiac myocytes from dying. We found that in this acute setting, heart attacks are bigger when Gi is blocked. As a result, the heart cant pump as well.

They would like to find out Gis role in chronic heart failure, where there is much less cell death occurring, and Gi levels remain high. In the chronic phase, Dr. Koch points out, Gi activity could be maladaptive. They plan to test the idea in chronic heart failure animal models.


Contact: Steve Benowitz
Thomas Jefferson University

Related medicine news :

1. Emory researchers identify signaling protein for multiple myeloma
2. Cooper Clinic at Craig Ranch Opens Signaling the Next Phase of CooperLife Health-Focused Residential Community in McKinney
3. Scientists shed light on long-distance signaling in developing neurons
4. St. Jude finds signaling system that halts the growth of a childhood brain cancer
5. Draining away brains toxic protein to stop Alzheimers
6. Penn study finds pro-death proteins required to regulate healthy immune function
7. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
8. Human C-reactive protein regulates myeloma tumor cell growth and survival
9. Lowering Blood Protein Wont Help Kidney Patients
10. Blood protein detects lung cancer, even at earliest stage
11. Natural Protein Could Help Spot, Treat Liver Cancer
Post Your Comments:
(Date:11/25/2015)... ... 25, 2015 , ... Additional breast cancers found with MRI ... to a study published online in the journal Radiology. Researchers said that in ... a change in treatment. , Breast MRI is the most sensitive technique for ...
(Date:11/25/2015)... ... 25, 2015 , ... TyloHelo Inc , North America’s ... Sauna accessories help improve the bather experience in the sauna, and the accessories ... the purist looking for simplicity in design to accessories that encourage a greater ...
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... According to ... surgical robot is being more and more widely heralded as a breakthrough for performing ... Vinci method has over traditional laparoscopic surgery is that it can greatly reduce the ...
(Date:11/25/2015)... ... , ... The McHenry County law firm of Botto Gilbert Lancaster, PC ... J. Botto and Alex C. Wimmer. Attorneys Botto and Wimmer represented the claimant David ... 130884WC. , According to court documents, Adcock testified that on May 10, 2010 he ...
(Date:11/25/2015)... ... November 25, 2015 , ... Brillianteen, McGaw YMCA’s ... learning in its 65th Anniversary Brillianteen Revue, scheduled for March 4-6, 2016. Auditions ... 65 years, Brillianteen has been a treasured tradition for numerous families in the ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... AVACEN Medical announced the issue of United States patent No. 9,192,509  entitled: ... patent shields the company,s AVACEN 100 dry heat therapy medical device and specific methods of use, ... Photo - ... ... ...
(Date:11/25/2015)... 25, 2015 USP 800 applies to ... (e.g. pharmacists, pharmacy technicians, nurses, physicians, physician assistants, ... chapter also covers all entities which store, prepare, ... other healthcare institutions, patient treatment clinics, physicians, practice ... --> What is the purpose ...
(Date:11/25/2015)... , Nov. 25, 2015  Mindray ... (NYSE: MR ), a leading ... devices worldwide, today announced that it ... meeting of shareholders at the Company,s Hong ... Century, 193 Prince Edward West Road, Mongkok ...
Breaking Medicine Technology: