Navigation Links
Signaling protein helps limit damage in heart attack, Jefferson scientists show
Date:3/21/2008

(PHILADELPHIA) Scientists at the Center for Translational Medicine at Thomas Jefferson University in Philadelphia have shown that a specific signaling protein is crucial to protecting the heart and helping it to adapt during a heart attack.

The protein Gi is known to have increased activity in the failing heart, but researchers have never been sure if it was helping the heart adapt to damage or if it was actually causing more heart cells to die. The Jefferson team, led by Walter Koch, Ph.D., W.W. Smith Professor of Medicine and director of the Center for Translational Medicine in the Department of Medicine at Jefferson Medical College, experimentally blocked the protein in the hearts of genetically engineered mice experiencing heart attacks. They found that the animals had greater heart damage than did similar mice with a working protein. The team reports its findings March 18, 2008, in the journal Circulation.

Gi is important in intracellular signaling, akin to a molecular switch, Dr. Koch notes. Its not a new drug target, he explains, but the activation of some receptors (such as beta-2 adrenergic receptors) that also turn on Gi could be targets.

Developing a class-specific Gi inhibitor, Dr. Koch explains, is an important step to understanding Gis role and behavior. We dont have to worry about what receptor we are blocking; were blocking a receptor that couples with Gi. We never had the tools before to tell if Gi activation was good or bad. We think that we can now begin to test the role of Gi in cardiac injury.

In the work, Dr. Kochs group developed a transgenic mouse with a functional knockout of the Gi gene, meaning that it lacked a working gene. The scientists then simulated a heart attack, catheterization and reperfusion by tieing off a coronary artery for 30 minutes and subsequently reestablishing the blood flow, causing an inflammatory response and tissue damage.

It appears that in this setting
'/>"/>

Contact: Steve Benowitz
steven.benowitz@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Emory researchers identify signaling protein for multiple myeloma
2. Cooper Clinic at Craig Ranch Opens Signaling the Next Phase of CooperLife Health-Focused Residential Community in McKinney
3. Scientists shed light on long-distance signaling in developing neurons
4. St. Jude finds signaling system that halts the growth of a childhood brain cancer
5. Draining away brains toxic protein to stop Alzheimers
6. Penn study finds pro-death proteins required to regulate healthy immune function
7. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
8. Human C-reactive protein regulates myeloma tumor cell growth and survival
9. Lowering Blood Protein Wont Help Kidney Patients
10. Blood protein detects lung cancer, even at earliest stage
11. Natural Protein Could Help Spot, Treat Liver Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... To accommodate the ever-growing customer base, Angeldress.co.uk decided to ... Recently, the company has unveiled its 2014 vintage ... wedding gowns, Angeldress.co.uk wants to make sure that all ... way. Its high quality vintage wedding outfits are now ... 62% off. , Online shopping is becoming more and ...
(Date:9/21/2014)... September 21, 2014 “Cluster headaches are ... intense and difficult to resolve,” said Steve Young of ... think of a pain that is more intense.” , ... from cluster headaches, or migraines, that medical research is ... serotonin system,” he added. , Serotonin (5-HT, 5-hydroxytryptamine) is ...
(Date:9/21/2014)... C8 lawsuits move forward in the U.S. ... of 20 possible C8 lawsuits selected for bellwether ... Wright & Schulte LLC. Court records show these six ... lawsuits filed that represent individuals who purportedly developed kidney ... of being exposed to water contaminated by the C8 ...
(Date:9/20/2014)... Recently, UWDress.com, a professional company of women’s dresses ... newly announced evening cocktail dresses . As a ... outfits are very popular among worldwide customers. Now, all ... (up to 65 percent off). , All UWDress.com’s ... occasion outfits for the global clients. The company is ...
(Date:9/20/2014)... (PRWEB) September 20, 2014 David Cooke ... 2014. The first poster looked at the clinical benefits ... cycle for calculating diastolic function. In conjunction with colleagues ... renal disease and normal LVEF by echo (>50%). Each ... protocol, and standard SPECT. Emory Toolbox 4.0 ...
Breaking Medicine News(10 mins):Health News:Angeldress.co.uk Launches New Range Of 2014 Vintage Wedding Dresses In Its Online Store 2Health News:Homeostasis: Equinox Serotonin (5HT) Headache Stories ~ New on the Bryan William Brickner Blog 2Health News:C8 Lawsuit Claims Move Forward as Six Possible Cases for Bellwether Trials Selected in DuPont Water Contamination Lawsuits, Reports Wright & Schulte LLC 2Health News:C8 Lawsuit Claims Move Forward as Six Possible Cases for Bellwether Trials Selected in DuPont Water Contamination Lawsuits, Reports Wright & Schulte LLC 3Health News:C8 Lawsuit Claims Move Forward as Six Possible Cases for Bellwether Trials Selected in DuPont Water Contamination Lawsuits, Reports Wright & Schulte LLC 4Health News:Cheap Evening Cocktail Dresses Recently Introduced At UWDress.com 2Health News:Versatility of Emory Toolbox 4.0 Shown at ASNC in Scientific Posters 2Health News:Versatility of Emory Toolbox 4.0 Shown at ASNC in Scientific Posters 3
... Menveo not available in US yet, British researchers note , , ... meningitis vaccine appears to offer protection for babies against several ... and Canadian researchers report. , The new vaccine, which is ... four strains of meningococcal disease in all age groups, according ...
... a stage, then proteins would rank among the lead ... These large biological molecules hold many starring roles, and ... genes. They are production powerhouses, regulating the basic processes ... that produce or use energy. Others regulate genes. , ...
... enjoy things less. Such satiation causes our favorites to lose ... pushes us to escalate our spending on novelty. Life has ... better and better experiences just to stay happy. However, new ... Research finds that paying attention to details can help us ...
... and Queens Groups Will Work to Prevent Sudden Cardiac,Arrest, ... 8 The Sudden Cardiac Arrest,Association (SCAA) announced today ... it builds a network of local organizations to help ... The Queens chapter is led by Lorraine Monaghan, ...
... Work to Prevent Sudden Cardiac Arrest, Through Public ... Sudden Cardiac Arrest,Association (SCAA) announced today that it has ... of local organizations to help carry out,its mission of ... chapter is led by Connie Snell of Austin who ...
... WASHINGTON, Jan. 8 The Department of Labor,s,Occupational ... comment period for the review of its methylene ... was originally announced in,the July 10, 2007, Federal ... issued the Standard in 1997 to protect employees ...
Cached Medicine News:Health News:New Meningitis Vaccine Works in Infants 2Health News:New Meningitis Vaccine Works in Infants 3Health News:Protein power: Researchers trigger insulin production in diabetic mice 2Health News:Protein power: Researchers trigger insulin production in diabetic mice 3Health News:Trying to stay on a strict diet? Focus on the details 2Health News:Sudden Cardiac Arrest Association Launches Long Island and Queens Chapters 2Health News:Sudden Cardiac Arrest Association Launches Long Island and Queens Chapters 3Health News:Sudden Cardiac Arrest Association Launches Austin and Lubbock Chapters 2Health News:Sudden Cardiac Arrest Association Launches Austin and Lubbock Chapters 3Health News:OSHA Extends Comment Period for Lookback Review of Methylene Chloride Standard 2
(Date:9/19/2014)... , Sept. 19, 2014  BioSpecifics Technologies Corp. (NASDAQ: ... class collagenase-based products marketed as XIAFLEX ® in the ... that BioSpecifics, President, Tom Wegman , will present a ... in the Biotech Industry Conference. The presentation ... p.m. EDT at the Millennium Broadway Hotel in ...
(Date:9/19/2014)... , Sept. 19, 2014  Over 200 runners ... Future to Benefit the Radiation Oncology Institute (ROI), hosted ... at Golden Gate Park in San Francisco.  ... Moore , CEO of Radiation Business Solutions, "but ... have raised over $70,000 for the ROI this year. ...
(Date:9/19/2014)... Mass. , Sept. 19, 2014   Personal ... advanced cancer genome analysis and testing services, and ... and developing highly selective kinase inhibitors for genomically ... study of malignant mixed Mullerian tumors (MMMT), an ... system, also known as carcinosarcoma. The new ...
Breaking Medicine Technology:BioSpecifics Technologies Corp. to Present at the 21st Annual BioCentury NewsMakers in the Biotech Industry Conference 2Fifth Annual 5K Run for the Future to Benefit the Radiation Oncology Institute Breaks Attendance, Donation Records 2Fifth Annual 5K Run for the Future to Benefit the Radiation Oncology Institute Breaks Attendance, Donation Records 3First Discovery Of Actionable Genetic Alterations In A Deadly Cancer Reported By Personal Genome Diagnostics And Blueprint Medicines 2First Discovery Of Actionable Genetic Alterations In A Deadly Cancer Reported By Personal Genome Diagnostics And Blueprint Medicines 3First Discovery Of Actionable Genetic Alterations In A Deadly Cancer Reported By Personal Genome Diagnostics And Blueprint Medicines 4
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: