Navigation Links
Signaling pathways point to vulnerability in breast cancer stem cells
Date:6/9/2011

hat work together to maintain migratory and self-renewing traits of both normal breast epithelial and breast cancer cells. These pathways are continuously activated in the stem cells by autocrine signals; that is, signals produced by the cells themselves. Studying how these autocrine signals function in breast epithelial cells allowed Scheel to specify the signals that allow these cells to pass through an EMT and enter into a mesenchymal and stem cell-like state in the first place. Her findings are published in the June 10 issue of Cell.

Interestingly, Scheel discovered that epithelial cells are kept in their differentiation state via inhibition of the three signaling pathways, that is, normal epithelial cells naturally produce proteins that block these signaling proteins. To push normal breast epithelial cells through an EMT in vitro, she removed these endogenous inhibitors by administering a cocktail of neutralizing antibodies and added growth factors that stimulate the three pathways, thereby mimicking the autocrine signaling found in mesenchymal cells. By applying the resulting EMT-inducing cocktail continuously, Scheel pushed the cells into a mesenchymal and stem cell-like state, with associated increased migratory ability and stem cell-like characteristics. Eventually, the former epithelial cells stabilized this state through autocrine signaling and were no longer dependent on the EMT cocktail.

To see the effects of blocking this autocrine signaling in an animal model, Scheel implanted into mice human breast cancer epithelial cells that had passed through an EMT. She then injected the implantation site with proteins that block the three pathways. The injected mice had one-tenth the number of tumors found in mice that did not receive the inhibitory proteins. In addition, breast cancer cells that were pre-treated in vitro with these proteins displayed a greatly reduced ability to metastasize when subsequently implanted into mice.

<
'/>"/>
Contact: Nicole Giese
giese@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Signaling pathway reveals mechanism for B cell differentiation in immune response
2. New study finds compounds show promise in blocking STAT3 signaling as treatment for osteosarcoma
3. Researchers identify the metabolic signaling pathway responsible for dyslipidemia
4. Naturally occurring brain signaling chemical may be useful in understanding Parkinsons
5. Researchers discover signaling pathway crucial to acute lung injury
6. Link between signaling molecules could point way to therapies for epilepsy, stroke, other diseases
7. Researchers discover new signaling pathway linked to inflammatory disease
8. UCLA cancer researchers discover new signaling pathway that controls cell development and cancer
9. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
10. A high-fat diet alters crucial aspects of brain dopamine signaling
11. Different signaling pathways of cholangiocarcinoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... Thompson HealthDay Reporter ... the womb to household chemicals known as phthalates might ... University researchers reported in a new study. Children ... asthma between age 5 and 11 if their mothers ... phthalates (pronounced thal-ates), the researchers found. The two phthalates ...
(Date:9/17/2014)... R.I. [Brown University] As Congress adjourns this month ... senators will step over on their way out the ... Repeal and Medicare Provider Payment Modernization Act of 2014. ... Surgery , Dr. Eli Adashi recounts what he and ... bipartisan bill. The perennial trouble with how Medicare pays ...
(Date:9/17/2014)... Boston Children’s Museum and From ... concert series, introducing young Museum visitors to musicians ... premier national platform celebrating the stories, talents, and ... young musicians featured will also be showcased on ... is fortunate to partner with the wonderful musicians ...
(Date:9/17/2014)... 2014 StartX , a nonprofit ... raising rounds of funding at its Summer Demo Day ... and media, was the first such gathering held at ... the university. The presentations were delivered on an expansive ... Labs, a 2,000 square foot life science facility that ...
(Date:9/17/2014)... 17, 2014 The in vitro diagnostics ... technology market, focusing on molecular diagnostics for conditions such ... genetic testing. The IVD market value is projected to ... of 2017. The major drivers of the market’s growth ... which is evidenced by the explosion for raid and ...
Breaking Medicine News(10 mins):Health News:Prenatal Exposure to Chemicals in Plastics Linked to Asthma Risk in Kids 2Health News:Prenatal Exposure to Chemicals in Plastics Linked to Asthma Risk in Kids 3Health News:Prenatal Exposure to Chemicals in Plastics Linked to Asthma Risk in Kids 4Health News:Failed Medicare payments law remains relevant 2Health News:Failed Medicare payments law remains relevant 3Health News:Boston Children's Museum Partners with From the Top to Offer Monthly Concert Series 2Health News:Boston Children's Museum Partners with From the Top to Offer Monthly Concert Series 3Health News:Stanford-affiliated StartX Showcases Startups, New HQ, and Growth of Stanford-StartX Fund 2Health News:Stanford-affiliated StartX Showcases Startups, New HQ, and Growth of Stanford-StartX Fund 3Health News:Stanford-affiliated StartX Showcases Startups, New HQ, and Growth of Stanford-StartX Fund 4Health News:Stanford-affiliated StartX Showcases Startups, New HQ, and Growth of Stanford-StartX Fund 5Health News:Stanford-affiliated StartX Showcases Startups, New HQ, and Growth of Stanford-StartX Fund 6Health News:World In Vitro Diagnostics Market Analysed by VPG in In-demand Research Report Available at MarketPublishers.com 2Health News:World In Vitro Diagnostics Market Analysed by VPG in In-demand Research Report Available at MarketPublishers.com 3
... Simon J. ... NJHCFFA. , ... --Simon J. Samaha, M.D., recently was confirmed by the New Jersey State Senate as one of ... (The Authority). , , , , ,Dr. Samaha is the President and Chief Executive Officer of ...
... Perkins Warns Houston "Abortion Super Center" Will Be Prototype ... Jan. 18 An estimated 10,000 people converged on ... across from the nation,s largest abortion facility.  Tony Perkins, president of ... Call to Conscience in Houston today to rally pro-life ...
... to ask simple question of male patients , MONDAY, ... strong warning sign that a man might be at ... problems, a long-running study indicates. , "We saw that ... men with erectile function still had a 40 percent ...
... experts stress that ,senior moments, don,t guarantee that dementia ... News) -- Mental lapses among older adults occur more ... new research finds. , Excessive daytime sleepiness, staring into ... fluctuations that often precede Alzheimer,s, say researchers from Washington ...
... 18 An urgent aid shipment containing 4,000 tents and ... Haitian coastal town of Jacmel. , Jacmel, 30 miles southwest of ... devastated by the recent earthquake with more than 350 people reported ... that 60 percent of buildings were damaged or destroyed. , An ...
... to Run in Honor of People With Cystic Fibrosis , ... Fibrosis Foundation,s most active volunteers will carry the Olympic Torch today in ... Opening Ceremony of the 2010 Olympic Winter Games. , Liz Burns ... than $600,000 for CF research, care and education programs. She is ...
Cached Medicine News:Health News:Simon J. Samaha, M.D., Appointed Public Member of New Jersey Health Care Facilities Financing Authority 2Health News:FRC's Tony Perkins Speaks to Rally of Ten Thousand Across from Nation's Largest Abortion Facility 2Health News:Erectile Dysfunction Predicts Heart Disease 2Health News:Frequent Mental Lapses May Precede Alzheimer's 2Health News:Frequent Mental Lapses May Precede Alzheimer's 3Health News:Haiti: Lifesaving Aid Makes Its Way Through to Quake-Hit Jacmel by Ship 2Health News:Cystic Fibrosis Foundation Volunteer to Carry Torch for Vancouver 2010 Olympic Winter Games 2
(Date:9/17/2014)... ROSEVILLE, Minn. , Sept. 17, 2014  Rebiotix Inc. ... of the company,s lead product candidate, RBX2660 (microbiota suspension) will ... the IDWeek 2014 conference in Philadelphia ... will be presented during the poster session on Thursday, October ... C. difficile Infection: 60-Day Interim Analysis of the ...
(Date:9/17/2014)... DALLAS , Sept. 17, 2014   OTEMR, ... 2014 Edition Complete EHR certification, which designates that the ... the Stage 1 and Stage 2 Meaningful Use measures ... and Reinvestment Act (ARRA).  ONETOUCH EMR 2.0 was certified ... an Office of the National Coordinator-Authorized Certification Body (ONC-ACB) ...
(Date:9/17/2014)... of people suffer from neck and arm pain as a ... FDA approved the launch of a clinical trial for the ... Spinal Kinetics, which may offer relief to people with cervical ... for Special Surgery (HSS), the number one orthopedic hospital in ... York City and in the Northeast participating in ...
Breaking Medicine Technology:PUNCH CD Study Drug Targeting Recurrent C. difficile Infection to be Presented at IDWeek 2014 2PUNCH CD Study Drug Targeting Recurrent C. difficile Infection to be Presented at IDWeek 2014 3PUNCH CD Study Drug Targeting Recurrent C. difficile Infection to be Presented at IDWeek 2014 4OTEMR, Inc.'s ONETOUCH EMR Achieves ONC HIT 2014 Edition COMPLETE EHR Certification from ICSA Labs 2OTEMR, Inc.'s ONETOUCH EMR Achieves ONC HIT 2014 Edition COMPLETE EHR Certification from ICSA Labs 3Cervical Disc Clinical Trial for People with Neck and Arm Pain Set to Begin at Hospital for Special Surgery 2
The Pan Retinal® 2.2 uniquely combines magnification nearly that of the 20D lens with a field of view approaching that of the 30D lens. Excellent for virtually every examination procedure, includ...
Provides exceptional resolution and fundus scanning capability. Excellent for small pupil diagnosis and treatment....
The Professional ophthalmoscope has been designed to ensure ultimate control. Lenses, graticules and filters can all be introduced at the touch of a fingertip without the need to pull away from the p...
... MK-2000 Keratome System provides ... wide range of applications. ... ultra-sharp stainless steel disposable ... sterile and ready to ...
Medicine Products: