Navigation Links
Signaling pathways point to vulnerability in breast cancer stem cells
Date:6/9/2011

CAMBRIDGE, Mass. (June 9, 2011) Whitehead Institute researchers have identified signals from breast epithelial cells that can induce those cells to transition to and maintain a mesenchymal and stem cell-like cell state that imbues both normal and cancer cells with a greater ability to migrate and self-renew. Interrupting these signals strips the cells of the migratory, invasive and self-renewal abilities used by cancer stem cells to seed new tumors.

"Stem cells are important in both cancers and normal tissues. On the one hand we'd like to know what creates so-called cancer stem cells in tumors and on the other hand we'd like to know what creates normal stem cells in normal epithelial tissues," says Whitehead Founding Member Robert Weinberg. "We have reason to believe that these two dynamics are orchestrated by a common regulatory machinery. So this work may be applicable for understanding both breast cancer cells and normal epithelial cells, such as the normal cells in the normal mammary ducts."

During an epithelial-to-mesenchymal transition (EMT), epithelial cells acquire the traits of mesenchymal cells. Unlike the tightly-packed epithelial cells that stick to one another, mesenchymal cells are loose and free to move around a tissue. The attributes of mesenchymal cells are beneficial during development, but when hijacked by cancer cells, confer the ability to migrate to distant sites. In addition, the passage through an EMT enables adult cancer cells to seed new tumors with high efficiency, the hallmark trait of cancer stem cells. Although passage through an EMT is recognized as an important step in the formation of cancer stem cells, scientists have been unable to clearly identify the cues in a cell's microenvironment that induce an EMT.

By studying human breast epithelial cells, Christina Scheel, a postdoctoral researcher in the Weinberg lab, pinpointed three signaling pathways (TGF-beta, non-canonical Wnts, and canonical Wnts) t
'/>"/>

Contact: Nicole Giese
giese@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Signaling pathway reveals mechanism for B cell differentiation in immune response
2. New study finds compounds show promise in blocking STAT3 signaling as treatment for osteosarcoma
3. Researchers identify the metabolic signaling pathway responsible for dyslipidemia
4. Naturally occurring brain signaling chemical may be useful in understanding Parkinsons
5. Researchers discover signaling pathway crucial to acute lung injury
6. Link between signaling molecules could point way to therapies for epilepsy, stroke, other diseases
7. Researchers discover new signaling pathway linked to inflammatory disease
8. UCLA cancer researchers discover new signaling pathway that controls cell development and cancer
9. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
10. A high-fat diet alters crucial aspects of brain dopamine signaling
11. Different signaling pathways of cholangiocarcinoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 22, 2015 IsoComforter, Inc. has introduced the ... patented IsoTube design to treat specific body parts and muscle ... progressive and easy to use patented cold therapy machine with ... related orthopedic and muscle injuries. IsoComforter has become the ...
(Date:1/22/2015)... Payday lending practices in four southern ... financial distress to the states that permit them, according ... Center on Race and Wealth. , While they generate ... loans at the same time substantially depress economic activity, ...
(Date:1/22/2015)... New York, NY (PRWEB) January 22, 2015 ... component of overall health care gains momentum worldwide, Rev. ... York-based HealthCare Chaplaincy Network (HCCN), will be the ... advance spiritual care in Israel’s public health system. , The ...
(Date:1/22/2015)... has released a new blog post presenting a list of vehicles ... , Some types of vehicles cannot be covered under an ... post to see if their vehicle qualifies for auto insurance coverage. ... the cars that cannot be covered by a plan. Clients have ...
(Date:1/22/2015)... Step into a macabre world where plants ... Virginia. Wicked Plants, the Museum’s latest featured exhibition, opens ... carnivorous and diabolical plants inside of a dilapidated, Victorian ... biochemical, physical and neurological processes between botanicals and the ...
Breaking Medicine News(10 mins):Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 3Health News:Some Vehicles Cannot Be Covered By An Auto Insurance Policy! 2Health News:Wicked Plants are taking over the Science Museum of Virginia 2
... have come one step closer to understanding how the ... common drugs, including some antibiotics, antihistamines and anti-psychotics, can ... estimated around 40-50% of all drugs in development will ... in the heart and, as a result, can cause ...
... Maureen Salamon HealthDay Reporter , THURSDAY, Jan. 27 ... restaurant opening in his small Louisiana town, where vacant storefronts ... Burley, an assistant professor of sociology at Southeastern Louisiana University, ... of flat-screened TVs -- one in every booth -- along ...
... , THURSDAY, Jan. 27 (HealthDay News) -- U.S. health authorities ... patients using Truvada, the once-a-day combination pill that was shown ... high-risk individuals. The guidance, from experts at the U.S. ... and bisexual men at high risk for contracting the virus ...
... unprecedented crisis in our health care system," reported J. Fred ... at today,s annual State of the Nation,s Health Care briefing. ... We have more uninsured people than ever before. We ... Health care costs are increasing at rates that the countryand ...
... Researchers from McGill University,s Rosalind and Morris Goodman Cancer ... University Health Centre (RI MUHC), the DanaFarber Cancer Institute ... that can accurately predict which breast cancer patients are ... not from the burdens associated with unnecessary treatment. ...
... stimulants tend to choose instant gratification or a smaller but ... reward is greater. Reduced value of a future reward, ... treatment of addiction. A new study in the February 2011 ... present a strategy for increasing the value of future rewards ...
Cached Medicine News:Health News:Victor Chang scientists unlock the 'gates' on sudden cardiac death 2Health News:TV: A Sneaky Part of the Food Pyramid 2Health News:TV: A Sneaky Part of the Food Pyramid 3Health News:CDC Issues Guidance on Daily Pill to Prevent Infection With HIV 2Health News:CDC Issues Guidance on Daily Pill to Prevent Infection With HIV 3Health News:ACP says Congress must find 'common ground' to address 'crisis in our health care system' 2Health News:ACP says Congress must find 'common ground' to address 'crisis in our health care system' 3Health News:Memory training explored as strategy for addiction treatment 2Health News:Memory training explored as strategy for addiction treatment 3
(Date:1/22/2015)... , Jan. 22, 2015 /PRNewswire/ - Pivotal Therapeutics Inc. (OTCQX:PVTTF; ... a focus on Omega-3 therapies for cardiovascular disease and overall ... the Company,s accomplishments in 2014 and its outlook for 2015 ... Dear Fellow Shareholders, We would like to take ...
(Date:1/22/2015)... 22, 2015  Profil Institute for Clinical Research, Inc., a ... announced today a new textbook,  Translational Research Methods for ... a leading global scientific publisher. The textbook ... for use in early phase clinical studies of new ...
(Date:1/22/2015)... DUBLIN , Jan. 22, 2015 Research and ... the addition of the "Microbiology Testing/Clinical Microbiology ... - Global Forecast to 2019" report to ... a wide array of techniques for the detection ...
Breaking Medicine Technology:Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 2New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 3Global Microbiology Testing/Clinical Microbiology (Instrument, Analyzer, Incubator, Kit, Microscope, Molecular Diagnostics) Market - Forecast to 2019 2Global Microbiology Testing/Clinical Microbiology (Instrument, Analyzer, Incubator, Kit, Microscope, Molecular Diagnostics) Market - Forecast to 2019 3
... ... ... , , ... PHOENIX , ...
... ... ... ... ...
Cached Medicine Technology:INSYS Therapeutics, Inc. Announces Positive Phase III Efficacy Trial Results for Fentanyl Sublingual Spray 2INSYS Therapeutics, Inc. Announces Positive Phase III Efficacy Trial Results for Fentanyl Sublingual Spray 3INSYS Therapeutics, Inc. Announces Positive Phase III Efficacy Trial Results for Fentanyl Sublingual Spray 4Genomic Health Announces Publication of Study Using Oncotype DX(R) in Node-Negative and Node-Positive Breast Cancer Patients Treated With Aromatase Inhibitors 2Genomic Health Announces Publication of Study Using Oncotype DX(R) in Node-Negative and Node-Positive Breast Cancer Patients Treated With Aromatase Inhibitors 3Genomic Health Announces Publication of Study Using Oncotype DX(R) in Node-Negative and Node-Positive Breast Cancer Patients Treated With Aromatase Inhibitors 4Genomic Health Announces Publication of Study Using Oncotype DX(R) in Node-Negative and Node-Positive Breast Cancer Patients Treated With Aromatase Inhibitors 5Genomic Health Announces Publication of Study Using Oncotype DX(R) in Node-Negative and Node-Positive Breast Cancer Patients Treated With Aromatase Inhibitors 6Genomic Health Announces Publication of Study Using Oncotype DX(R) in Node-Negative and Node-Positive Breast Cancer Patients Treated With Aromatase Inhibitors 7Genomic Health Announces Publication of Study Using Oncotype DX(R) in Node-Negative and Node-Positive Breast Cancer Patients Treated With Aromatase Inhibitors 8
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: