Navigation Links
Signaling pathways point to vulnerability in breast cancer stem cells
Date:6/9/2011

CAMBRIDGE, Mass. (June 9, 2011) Whitehead Institute researchers have identified signals from breast epithelial cells that can induce those cells to transition to and maintain a mesenchymal and stem cell-like cell state that imbues both normal and cancer cells with a greater ability to migrate and self-renew. Interrupting these signals strips the cells of the migratory, invasive and self-renewal abilities used by cancer stem cells to seed new tumors.

"Stem cells are important in both cancers and normal tissues. On the one hand we'd like to know what creates so-called cancer stem cells in tumors and on the other hand we'd like to know what creates normal stem cells in normal epithelial tissues," says Whitehead Founding Member Robert Weinberg. "We have reason to believe that these two dynamics are orchestrated by a common regulatory machinery. So this work may be applicable for understanding both breast cancer cells and normal epithelial cells, such as the normal cells in the normal mammary ducts."

During an epithelial-to-mesenchymal transition (EMT), epithelial cells acquire the traits of mesenchymal cells. Unlike the tightly-packed epithelial cells that stick to one another, mesenchymal cells are loose and free to move around a tissue. The attributes of mesenchymal cells are beneficial during development, but when hijacked by cancer cells, confer the ability to migrate to distant sites. In addition, the passage through an EMT enables adult cancer cells to seed new tumors with high efficiency, the hallmark trait of cancer stem cells. Although passage through an EMT is recognized as an important step in the formation of cancer stem cells, scientists have been unable to clearly identify the cues in a cell's microenvironment that induce an EMT.

By studying human breast epithelial cells, Christina Scheel, a postdoctoral researcher in the Weinberg lab, pinpointed three signaling pathways (TGF-beta, non-canonical Wnts, and canonical Wnts) t
'/>"/>

Contact: Nicole Giese
giese@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Signaling pathway reveals mechanism for B cell differentiation in immune response
2. New study finds compounds show promise in blocking STAT3 signaling as treatment for osteosarcoma
3. Researchers identify the metabolic signaling pathway responsible for dyslipidemia
4. Naturally occurring brain signaling chemical may be useful in understanding Parkinsons
5. Researchers discover signaling pathway crucial to acute lung injury
6. Link between signaling molecules could point way to therapies for epilepsy, stroke, other diseases
7. Researchers discover new signaling pathway linked to inflammatory disease
8. UCLA cancer researchers discover new signaling pathway that controls cell development and cancer
9. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
10. A high-fat diet alters crucial aspects of brain dopamine signaling
11. Different signaling pathways of cholangiocarcinoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... and leadership of Senators Sherrod Brown (D-Ohio) and ... primary care services were lauded yesterday by the ... organizations, representing internal medicine and related subspecialties. ... for introducing the Ensuring Access to Primary Care ... will extend current-law payment rates under Medicaid for ...
(Date:9/22/2014)... 22, 2014) The success of a colonoscopy is ... prep often resulting in missed precancerous lesions, according to ... force on Colorectal Cancer. Additionally, poor bowel cleansing can ... Up to 20 to 25 percent of all colonoscopies ... , "When prescribing bowel preparation for their patients, health-care ...
(Date:9/22/2014)... weapons, the Office of Naval Research (ONR) this week ... Marine exposition that will prepare Marines as they continue ... program officers will be in Booth No. 2305 during ... Quantico, to discuss how their research contributes to the ... and lethal." , ONR,s Expeditionary Maneuver Warfare and Combating ...
(Date:9/22/2014)... Don Allred Insurance is pleased to announce the ... The satellite office, located in the Holly Hill Mall on ... and offer all of the same professional services as the ... spokesperson Scott Allred cites an expanding client base and the ... the major factors driving the decision to open a new ...
(Date:9/22/2014)... 22, 2014 IsoComforter, Inc., one of ... today the introduction of an innovative IsoTube technology and ... regulation. The IsoTube ridges provide optimal contact and pain ... from an insulated fluid reservoir to a pad that ... the system provides continuous cold therapy for an extended ...
Breaking Medicine News(10 mins):Health News:Broad physician coalition urges Congress to extend Medicaid pay parity 2Health News:Good bowel cleansing is key for high-quality colonoscopy 2Health News:Good bowel cleansing is key for high-quality colonoscopy 3Health News:Modern Day Marine: ONR features technology for marines of the future 2Health News:Allred Insurance to Open New Burlington Branch Office 2Health News:IsoComforter Cold Therapy Introduces Innovative IsoTube Technology 2
... PHILADELPHIA, Pennsylvania, June 4 ... Updates Findings Related to Australian Sponsored,Publication Practices From ... leading international publisher of scientific, technical and,medical (STM) ... moved,to provide consistent internal guidelines for its pharmaceutical ...
... , FRANKLIN, Mass., June 4 PLC Systems Inc. (OTC ... vascular medical device-based technologies, today announced the appointment of Louis ... Brenner, currently Senior Vice President at AMAG Pharmaceuticals, Inc., fills ... seek re-election. , , Dr. Brenner, 39, brings to ...
... research that has suggested excess weight worsens disease , THURSDAY, ... may not worsen asthma, as many experts have thought, but ... manage the chronic condition. , Inhaled corticosteroids are the most ... with asthma, many of whom are overweight or obese. , ...
... June 4 Last night, the America,s Health Insurance ... Keystone Mercy Health Plan, Group Health Cooperative of South ... plans with innovative programs designed to improve the health ... on a tradition among health plans of working with ...
... Research Hospital(R) celebrated its 7th annual FedEx/St. Jude Angels & ... on May 16th, at the InterContinental Hotel in Miami, Florida. ... El Gordo y La Flaca presented Tommy and ... to children,s causes and for their contributions to the entertainment ...
... Finding could help those with potentially deadly conditions , ... your blood miraculously stops flowing and forms a scab ... down to the molecular level. , "The human body ... and bruises," study co-author Wesley P. Wong, a principal ...
Cached Medicine News:Health News:Elsevier to Create New Guidelines for Pharmaceutical Article Reprint, Compilation and Custom Publications 2Health News:Elsevier to Create New Guidelines for Pharmaceutical Article Reprint, Compilation and Custom Publications 3Health News:PLC Systems Announces Appointment of Louis Brenner, M.D. to Board of Directors 2Health News:Obesity May Dampen Response to Asthma Meds 2Health News:AHIP Foundation Announces 2009 Community Leadership Awards 2Health News:Photos: Tommy & Thalia Mottola Honored at 7th Annual FedEx/St. Jude Angels & Stars Gala 2Health News:Photos: Tommy & Thalia Mottola Honored at 7th Annual FedEx/St. Jude Angels & Stars Gala 3Health News:Researchers Detect Blood-Clotting Mechanism 2
(Date:9/22/2014)... , Sept. 22, 2014 Auxilium ... specialty biopharmaceutical company, today announced that its Board ... non-binding and conditional proposal from Endo International plc ... and legal advisors, has unanimously determined it is ... its existing merger agreement with QLT Inc. ("QLT") ...
(Date:9/20/2014)... /CNW/ - The issue: Mylan Pharmaceuticals ULC Canada, in consultation ... Mylan-Nitro Spray 0.4 mg/metered dose due to the product missing ... A missing "dip tube" could pose a ... This defect may lead patients to believe they are receiving ... it. Not receiving nitroglycerin could place them at risk for ...
(Date:9/19/2014)... 19, 2014 A pharmaceutical executive in the ... three issues he wanted the research and consulting firm ... personnel (especially for secondary research) to maximize efficiency and ... increased workload , Automation of market research processes ... , How to implement and manage those automated systems ...
Breaking Medicine Technology:Auxilium Provides Transaction Update 2Auxilium Provides Transaction Update 3Auxilium Provides Transaction Update 4Auxilium Provides Transaction Update 5Auxilium Provides Transaction Update 6Advisory - Mylan Pharmaceuticals recalling nitroglycerin spray due to defective pump 2In Era of Competing Needs, Market Research Groups Under Pressure to Utilize Automation and External Staffing 2
... The complex cases performed,during this month,s ... Das, an interventional cardiologist at Presbyterian,Hospital of ... vascular,disease, a looming health concern as the ... heart disease. The country,s obesity epidemic will ...
... Calif., Oct. 26 Accuray,Incorporated (Nasdaq: ARAY ... radiosurgery,announced today that the company is partnering with ... in Houston, Texas to launch a prospective,clinical study ... Patients in the study will be randomly assigned ...
Cached Medicine Technology:Cardiologists Tackle 'Next Frontier' in Cardiovascular Disease 2M. D. Anderson Cancer Center to Lead Study of Surgery vs. CyberKnife(R) Radiosurgery for Operable Lung Cancer Patients 2M. D. Anderson Cancer Center to Lead Study of Surgery vs. CyberKnife(R) Radiosurgery for Operable Lung Cancer Patients 3M. D. Anderson Cancer Center to Lead Study of Surgery vs. CyberKnife(R) Radiosurgery for Operable Lung Cancer Patients 4
... PW 41 is a powerful, compact ... washers/aspirators, with built-in vacuum and dispensing ... ,are user-adjustable, with vertical and horizontal ... level detectors on wash and waste ...
... LHW is a solid made, manual ... Separate valves for dispense and aspirate ... comes complete with a stand and ... can be used, as well as ...
... ELx50 is a fast and versatile automated strip ... manifold. It is a self contained and programmable ... fluidic delivery from the gentle dripping of a ... pressure delivery systems. ELx50/12V processes 1 x 12 ...
... throughput washer for high ... throughput system washer is ... powerful dispensing line and ... stronger, external vacuum source. ...
Medicine Products: