Navigation Links
Signaling pathway reveals mechanism for B cell differentiation in immune response
Date:4/22/2011

An article in Science Signaling by researchers at the RIKEN Research Center for Allergy and Immunology (RCAI) has clarified for the first time the mechanism governing differentiation of B cells into antibody-producing plasma cells. The finding establishes a role for the extracellular signal-regulated kinase (ERK) signaling pathway in B cell differentiation, a key step toward the development of B cell-targeted drugs for treatment of autoimmune diseases and allergies.

As the only cells in the body that produce antibodies, B cells play an essential role in the immune system's defense against bacteria and viruses. Differentiation of B cells into antibody-producing plasma cells is central to this role, initiating the production of antibodies whose targeted binding mechanism enables the immune system to identify and neutralize foreign objects. The mechanism underlying this differentiation process, however, remains unknown.

To better understand this mechanism, the research group focused on the signaling of the extracellular signal-regulated kinases (ERK), intracellular signaling molecules known to play an important role in the cell cycle and survival of immune cells. Hoping to glean insights into the role of ERKs in B cell differentiation into plasma cells, the researchers generated mice deficient in two different ERKs, ERK1 and ERK2, and studied the effect of this deficiency on the fate of B cells.

What they found confirmed that ERKs are in fact essential to B cell differentiation: B cells in mice without these key molecules were unable to form plasma cells (Figure 1). The researchers further traced this observation to a gene called Prdm1 encoding the protein BLIMP-1, increased expression of which leads to differentiation and proliferation of plasma cells in B cell immune response (Figure 2). ERKs, they discovered, phosphorylate the transcription factor Elk1, which leads to expression of Blimp-1 (Figure 3).

By elucidating the role of ERKs in B cell differentiation, the current research provides valuable insight into a little-understood area of immune response, promising advances in drug discovery and offering hope to autoimmune disease and allergy sufferers around the world.


'/>"/>
Contact: Tomoko Ikawa
koho@riken.jp
81-484-621-225
RIKEN
Source:Eurekalert  

Related medicine news :

1. New study finds compounds show promise in blocking STAT3 signaling as treatment for osteosarcoma
2. Researchers identify the metabolic signaling pathway responsible for dyslipidemia
3. Naturally occurring brain signaling chemical may be useful in understanding Parkinsons
4. Researchers discover signaling pathway crucial to acute lung injury
5. Link between signaling molecules could point way to therapies for epilepsy, stroke, other diseases
6. Researchers discover new signaling pathway linked to inflammatory disease
7. UCLA cancer researchers discover new signaling pathway that controls cell development and cancer
8. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
9. A high-fat diet alters crucial aspects of brain dopamine signaling
10. Different signaling pathways of cholangiocarcinoma
11. New Cancer-Fighting Strategy Focuses On Signaling Molecules
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Signaling pathway reveals mechanism for B cell differentiation in immune response
(Date:5/26/2016)... ... May 26, 2016 , ... There are many ways to cook ... Council (NHDSC) suggests that Americans prefer their dogs straight off the grill. Of the ... is their favorite way to cook a hot dog, far outpacing other cooking methods ...
(Date:5/26/2016)... ... May 26, 2016 , ... Cabot Corporation, Pfizer, and 3M ... to court documents and SEC filings. A jury has returned a verdict ... Optical Corporation, Case No. BC588866, Los Angeles County, California. The jury awarded $22.8 ...
(Date:5/26/2016)... ... May 26, 2016 , ... Georgia ... to its specialty academic programs. , Answering to the increasing demand for curricular ... in health law, and environmental and land use law. ,  , “The demand ...
(Date:5/26/2016)... ... 2016 , ... On Memorial Day, Hope For Heroes and USA ... battle for the country. The nonprofit Hope For Heroes partnered with the leading ... independence for disabled military veterans, as well as police, firemen, and EMS professionals across ...
(Date:5/26/2016)... Pittsburgh, PA (PRWEB) , ... May 26, 2016 ... ... transplantation, and one that has a significant negative impact on long-term patient survival, ... to date. The results, published online this week in the Journal of Thoracic ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... 26, 2016 According to a new ... Market - U.S. Industry Analysis, Size, Share, Growth, Trends, and ... the U.S. was valued at US$ 5.89 Bn in 2014 ... from 2015 to 2023 to reach US$ 7.99 Bn in ... and emerging needle free drug delivery devices and the market ...
(Date:5/26/2016)... , May 26, 2016 ... Associated With Both Cost Savings and Overall ... plc (LSE: BTG), an international specialist healthcare company, ... at the 21st Annual Meeting of ISPOR (International ... treatment of hepatocellular carcinoma (HCC) using yttrium-90 glass ...
(Date:5/26/2016)... , May 26, 2016 Since ... matured into an essential life science tool for conducting ... applications. BCC Research reveals in its new report that ... growth phase, one powered by a range of new ...      (Logo: http://photos.prnewswire.com/prnh/20140723/694805 ) , ...
Breaking Medicine Technology: