Navigation Links
Signaling molecule identified as essential for maintaining a balanced immune response
Date:7/22/2011

(MEMPHIS, Tenn. July 22, 2011) St. Jude Children's Research Hospital investigators have identified a signaling molecule that functions like a factory supervisor to ensure that the right mix of specialized T cells is available to fight infections and guard against autoimmune disease.

The research also showed the molecule, phosphatase MKP-1, is an important regulator of immune balance. Working in laboratory cell lines and mice with specially engineered immune systems, scientists demonstrated that MKP-1 serves as a bridge between the innate immune response that is the body's first line of defense against infection and the more specialized adaptive immune response that follows. The results are published in the July 22 print edition of the scientific journal Immunity.

The results raise hopes that the MKP-1 pathway will lead to new tools for shaping the immune response, said Hongbo Chi, Ph.D., assistant member of the St. Jude Department of Immunology and the study's senior author. The co-first authors are Gonghua Huang, Ph.D., and Yanyan Wang, Ph.D., both postdoctoral fellows in Chi's laboratory.

The findings provide new details about how dendritic cells regulate the fate of nave or undifferentiated T cells. Dendritic cells are the sentinels of the innate immune response, patrolling the body and ready to respond at the first sign of infection.

Investigators were surprised that a single molecule regulated production of three out of the four major subsets of T cells, which each play different roles. MKP-1 is a negative regulator of the enzyme p38, which is part of the MAP kinase family of enzymes that control pathways involved in cell proliferation, differentiation and death.

Chi and his colleagues demonstrated that MKP-1 works in dendritic cells by altering production of protein messengers known as cytokines. Those cytokines determine which subset of specialized T cells the undifferentiated T cells are fated to beco
'/>"/>

Contact: Carrie Strehlau
carrie.strehlau@stjude.org
901-595-2295
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Defective signaling pathway sheds light on cystic fibrosis
2. Arsenic exposure activates an oncogenic signaling pathway; leads to increased cancer risk
3. New Cancer-Fighting Strategy Focuses On Signaling Molecules
4. Different signaling pathways of cholangiocarcinoma
5. A high-fat diet alters crucial aspects of brain dopamine signaling
6. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
7. UCLA cancer researchers discover new signaling pathway that controls cell development and cancer
8. Researchers discover new signaling pathway linked to inflammatory disease
9. Link between signaling molecules could point way to therapies for epilepsy, stroke, other diseases
10. Researchers discover signaling pathway crucial to acute lung injury
11. Naturally occurring brain signaling chemical may be useful in understanding Parkinsons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... The study, The Truth Behind Variation in ... care payments for four clinical areas—congestive heart failure, acute ... and knees). Using the definition of episodes of ... program, the study examines these clinical areas within the ... , “Our study reaffirms that, in most instances, the ...
(Date:7/30/2014)... Calling all runners in the Richmond, VA region. ... host a monthly Runner’s Injury Clinic at the ... the second Monday of each month through the end of ... 10 and December 8. , The clinics run from ... running shoes and attire, will receive a complimentary evaluation of ...
(Date:7/30/2014)... Park Cities Pet Sitter President , ... month to reinforce best practices when communicating with fellow ... institute the meetings when she realized how much more ... over the past decade. Even with the addition ... quicker processing of customer requests and information, and ...
(Date:7/30/2014)... (SCID) can be successfully treated with a transplant of ... Sloan Kettering,s Richard J. O,Reilly, MD, a world-renowned pioneer ... be published in the July 30 issue of the ... is a group of inherited disorders that cause the ... babies no longer have the ability to fight off ...
(Date:7/30/2014)... Washington, DC and Malaysia (PRWEB) July 30, 2014 ... impact lives through education by LTT Global an award ... been pioneering learning on the go since 2004. , ... free and quality learning content. MMU has links ... providers, universities, organizations, NGOs’ and subject matter experts from ...
Breaking Medicine News(10 mins):Health News:Recent Research Finds a New Driver of Cost Variation in Episode Payments 2Health News:Recent Research Finds a New Driver of Cost Variation in Episode Payments 3Health News:Tidewater Physical Therapy to Host Monthly Runner’s Injury Clinic at 3 Sports Glen Allen Location 2Health News:Tidewater Physical Therapy to Host Monthly Runner’s Injury Clinic at 3 Sports Glen Allen Location 3Health News:Dallas-Based Park Cities Pet Sitter Stresses the Importance of Mindful Communication in This Month’s Staff Meetings, In Addition to Teaching the Signs of Burnout 2Health News:Dallas-Based Park Cities Pet Sitter Stresses the Importance of Mindful Communication in This Month’s Staff Meetings, In Addition to Teaching the Signs of Burnout 3Health News:Dallas-Based Park Cities Pet Sitter Stresses the Importance of Mindful Communication in This Month’s Staff Meetings, In Addition to Teaching the Signs of Burnout 4Health News:Transplantation shown to be highly effective in treating immune deficiency in children 2Health News:MyMobileUniversity Inviting Individuals, Who Are Passionate about the Universal Right to Education, to Come on Board as Goodwill Ambassadors 2Health News:MyMobileUniversity Inviting Individuals, Who Are Passionate about the Universal Right to Education, to Come on Board as Goodwill Ambassadors 3
... of getting the heart disease in higher among teenagers ... de Simone and other researchers from the New York ... communities in Arizona, Oklahoma, and North and South Dakota, ... data from examinations of 460 participants aged 14-20 years ...
... In case you thought that you were a great exercise ... of urban air pollution, you might have to do a ... an environmentalist exhaust and smoke from buses, cars etc can ... this danger is expressed by Dr. Joseph T. Cooke, Associate ...
... by researchers from Cornell University has pointed out to the ... consequence of acid rain// and alteration in the soil nature ... establishment of factories in the U.S. ,The sugar ... eastern United States because of its high-priced lumber, syrup and ...
... the area of personalized genetics will soon enable people ... //This will be possible by scanning and deciphering the ... ,This is indeed a major achievement that can ... permitting the medical specialists to advice them based on ...
... after eating (traditionally called European siesta) has been confirmed by ... levels//. ,Brain cells responsible for mind and body ... switched off after eating, and thus we are in need ... ,A tiny protein called orexins was released from ...
... sponsored conference on aviation flu has called for ... involving all relevant institutions across the globe, including ... watchers and wildlife conservation societies to check spread ... attending the conference convened by the UN Food ...
Cached Medicine News:Health News:Growth Of Maple Trees Affected By Acid Rain 2Health News:Growth Of Maple Trees Affected By Acid Rain 3
(Date:7/30/2014)...   Medical Equipment Solutions, Corp. are pleased ... of Defense (US Army) contract valued at over $2 ... diagnostic machine and technical support staffing. As an 8-A ... Business Administration (SBA), Medical Equipment is proud to support ... medical diagnostic equipment. The SBA 8-A certification is a ...
(Date:7/30/2014)... INCLINE VILLAGE, Nev. , July 30, 2014 /PRNewswire/ ... today announced that company management will participate in the ... Boston , Massachusetts. The conference will occur on ... About PDL BioPharma, Inc. PDL BioPharma ... primarily of its Queen et al. antibody humanization patents ...
(Date:7/29/2014)... CAMBRIDGE, Mass. and HERZLIYA PITUACH, ... Inc. (OTCQX and NASDAQ OMX First North Premier, ... announces today that it has initiated the screening of ... trial exploring the safety and efficacy of bertilimumab in ... open-label trial will enroll 10-15 patients who will receive ...
Breaking Medicine Technology:Medical Equipment Solutions Corp. Awarded $2 Million contract To Service DoD 2PDL BioPharma to Participate in Jefferies 2014 Boston Healthcare Summit 2Immune Pharmaceuticals Commences Patient Screening For Bertilimumab Phase II Clinical Trial In Bullous Pemphigoid, A Rare Auto-Immune Disease Of The Skin 2Immune Pharmaceuticals Commences Patient Screening For Bertilimumab Phase II Clinical Trial In Bullous Pemphigoid, A Rare Auto-Immune Disease Of The Skin 3Immune Pharmaceuticals Commences Patient Screening For Bertilimumab Phase II Clinical Trial In Bullous Pemphigoid, A Rare Auto-Immune Disease Of The Skin 4Immune Pharmaceuticals Commences Patient Screening For Bertilimumab Phase II Clinical Trial In Bullous Pemphigoid, A Rare Auto-Immune Disease Of The Skin 5
... A Duke University pioneer in personalized medicine at today,s ... Conference said physicians must lead the way in changing ... care. , Dr. Ralph Snyderman, director of the Duke ... personalized medicine based on genetic and other individual patient ...
... 1 This fall, dog owners in New York City ... walk in the park. Veterinarians on the Mobile Dog Heart ... with a soundproof medical unit to perform free heart examinations ... disease. , (Photo: http://www.newscom.com/cgi-bin/prnh/20091001/CG85941 ) , In addition to ...
Cached Medicine Technology:Personalized Medicine Expert: Don't 'Fix It,' 'Predict It' 2Mobile Dog Heart Health Tour Stopping in Central Park to Provide Free Heart Examinations 2Mobile Dog Heart Health Tour Stopping in Central Park to Provide Free Heart Examinations 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: