Navigation Links
Signaling molecule identified as essential for maintaining a balanced immune response
Date:7/22/2011

(MEMPHIS, Tenn. July 22, 2011) St. Jude Children's Research Hospital investigators have identified a signaling molecule that functions like a factory supervisor to ensure that the right mix of specialized T cells is available to fight infections and guard against autoimmune disease.

The research also showed the molecule, phosphatase MKP-1, is an important regulator of immune balance. Working in laboratory cell lines and mice with specially engineered immune systems, scientists demonstrated that MKP-1 serves as a bridge between the innate immune response that is the body's first line of defense against infection and the more specialized adaptive immune response that follows. The results are published in the July 22 print edition of the scientific journal Immunity.

The results raise hopes that the MKP-1 pathway will lead to new tools for shaping the immune response, said Hongbo Chi, Ph.D., assistant member of the St. Jude Department of Immunology and the study's senior author. The co-first authors are Gonghua Huang, Ph.D., and Yanyan Wang, Ph.D., both postdoctoral fellows in Chi's laboratory.

The findings provide new details about how dendritic cells regulate the fate of nave or undifferentiated T cells. Dendritic cells are the sentinels of the innate immune response, patrolling the body and ready to respond at the first sign of infection.

Investigators were surprised that a single molecule regulated production of three out of the four major subsets of T cells, which each play different roles. MKP-1 is a negative regulator of the enzyme p38, which is part of the MAP kinase family of enzymes that control pathways involved in cell proliferation, differentiation and death.

Chi and his colleagues demonstrated that MKP-1 works in dendritic cells by altering production of protein messengers known as cytokines. Those cytokines determine which subset of specialized T cells the undifferentiated T cells are fated to beco
'/>"/>

Contact: Carrie Strehlau
carrie.strehlau@stjude.org
901-595-2295
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Defective signaling pathway sheds light on cystic fibrosis
2. Arsenic exposure activates an oncogenic signaling pathway; leads to increased cancer risk
3. New Cancer-Fighting Strategy Focuses On Signaling Molecules
4. Different signaling pathways of cholangiocarcinoma
5. A high-fat diet alters crucial aspects of brain dopamine signaling
6. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
7. UCLA cancer researchers discover new signaling pathway that controls cell development and cancer
8. Researchers discover new signaling pathway linked to inflammatory disease
9. Link between signaling molecules could point way to therapies for epilepsy, stroke, other diseases
10. Researchers discover signaling pathway crucial to acute lung injury
11. Naturally occurring brain signaling chemical may be useful in understanding Parkinsons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... Washington, DC (PRWEB) September 17, 2014 ... family history. Along with regular screening and examination, a ... In this episode of Epicure with the Chef ... GWMFA Urologist Dr. Paul Rusilko to prepare a delicious ... in our western diets that influence risk of prostate ...
(Date:9/17/2014)... Neon Sport and Fitmark have an exclusive ... most anticipated event, Joe Weider's Olympia Fitness & Performance ... take home a Neon Sport branded Fitmark Power Duffel ... Fitmark will hold entries for the special prize at ... , “There’s nothing more exciting than seeing our collective ...
(Date:9/17/2014)... Acceleratio Ltd., an innovative software development ... of Server Monitoring Toolkit , a web ... It brings real-time server monitoring via a live ... enhanced features that significantly improve troubleshooting and detection ... agentless data collection, a user-friendly interface, and many ...
(Date:9/17/2014)... (PRWEB) September 17, 2014 Stand Up ... and music, returns to the Theater at Madison Square ... the Bob Woodruff Foundation (BWF) and New York Comedy ... returning service members, veterans and their families. , ... John Mulaney, John Oliver, Bruce Springsteen, Brian Williams and ...
(Date:9/17/2014)... 17, 2014 Kamut International is pleased ... key ingredient in Michael Angelo’s new “Made With Organic” ... fully organic lasagna ready made, frozen meal. Michael Angelo’s ... and these new products align well with Kamut International’s ... KAMUT® Brand wheat must be grown certified organic. , ...
Breaking Medicine News(10 mins):Health News:Boost Prostate Health with Epicure with the Chef MDs 2Health News:Electrifying Sports Nutrition Brand, Neon Sport, Pairs with Global Fitness Bag & Luggage Brand, Fitmark Bags, for an Exclusive Giveaway at Olympia Expo, This Weekend 2Health News:New Server Monitoring Toolkit v6 Brings Real-Time Windows Server Monitoring and New Server Reports 2Health News:New Server Monitoring Toolkit v6 Brings Real-Time Windows Server Monitoring and New Server Reports 3Health News:Louis C.K., John Mulaney, John Oliver, Bruce Springsteen, Brian Williams & More to Perform at 8th Annual Stand Up for Heroes at Theater at Madison Square Garden, Nov. 5 2Health News:Louis C.K., John Mulaney, John Oliver, Bruce Springsteen, Brian Williams & More to Perform at 8th Annual Stand Up for Heroes at Theater at Madison Square Garden, Nov. 5 3Health News:Louis C.K., John Mulaney, John Oliver, Bruce Springsteen, Brian Williams & More to Perform at 8th Annual Stand Up for Heroes at Theater at Madison Square Garden, Nov. 5 4Health News:Louis C.K., John Mulaney, John Oliver, Bruce Springsteen, Brian Williams & More to Perform at 8th Annual Stand Up for Heroes at Theater at Madison Square Garden, Nov. 5 5Health News:KAMUT® Brand Wheat Delivers a High Quality Ingredient and Authentic Italian Taste for Michael Angelo’s New Ready-Made Meals featuring Organic Ingredients 2
... An international team of researchers says abortion stigma is ... women who,ve had abortions. As a result, they,re launching ... stigma surrounding abortion. Their invited paper, "Abortion ... published in the current journal, Women,s Health Issues ...
... people every day, are a surprisingly common cause of ... hospital after sustaining stepladder injuries, many of which resulted ... how improved design and user behavior can decrease the ... HFES 55th Annual Meeting presentation, "The Role of Human ...
... (HealthDay News) -- Many members of low-income families are not ... In assessing the families, eating patterns and the nutritional ... 70 percent of the 100 families, who were newly enrolled ... amounts of several vital nutrients, including vitamins A and C, ...
... sorafenib responded to the flu vaccine, which suggests the ... as previously feared, according to a study in ... Association for Cancer Research. Keith Flaherty, M.D., ... and a senior editor of Clinical Cancer Research, said ...
... of scheduling chemotherapy treatments has been substantially reduced by a ... from the Sauder School of Business at the University of ... Called Chemo SmartBook, the innovative new scheduling system ... from the Health Employers Association of British Columbia in the ...
... many, a tax on soda is a no-brainer in advancing the ... in recent years that conclude that sugary drinks have a lot ... obese people tend to drink diet sodas, and therefore taxing soft ... weapon in combating obesity, according to a new Northwestern University study. ...
Cached Medicine News:Health News:International team explores the stigma surrounding abortion 2Health News:Improved stepladder design may decrease injuries 2Health News:Low-Income Families Often Miss Out on Proper Nutrition 2Health News:Patients treated with sunitinib and sorafenib respond to flu vaccine 2Health News:Innovative UBC-BC Cancer Agency system reduces waitlisting for chemotherapy patients 2Health News:Innovative UBC-BC Cancer Agency system reduces waitlisting for chemotherapy patients 3Health News:Can soda tax curb obesity? 2
(Date:9/16/2014)... 16, 2014 This report analyzes the worldwide markets ... following Product Segments: SPECT Systems (Includes SPECT and SPECT/CT systems), ... provides separate comprehensive analytics for the US, Canada ... , Asia-Pacific , Latin ... forecasts are provided for the period 2013 through 2020. Also, ...
(Date:9/16/2014)... 16, 2014  ROX Medical today presented positive ... prospective, randomized, controlled, blinded endpoint study of the ... CONTROL-HTN trial, NCT01642498, evaluated the safety and efficacy ... between a central artery and vein in the ... The primary outcomes are reduction of blood ambulatory ...
(Date:9/16/2014)... A study led by St. Jude ... dose threshold below which male childhood cancer survivors are ... in September 17 edition of the journal Lancet ... at highest risk for reduced sperm production as adults, ... pre-treatment fertility preservation methods such as sperm banking. ...
Breaking Medicine Technology:Global Nuclear Medicine Imaging Equipment Industry 2Global Nuclear Medicine Imaging Equipment Industry 3Global Nuclear Medicine Imaging Equipment Industry 4Global Nuclear Medicine Imaging Equipment Industry 5Global Nuclear Medicine Imaging Equipment Industry 6Global Nuclear Medicine Imaging Equipment Industry 7Global Nuclear Medicine Imaging Equipment Industry 8Global Nuclear Medicine Imaging Equipment Industry 9Global Nuclear Medicine Imaging Equipment Industry 10Global Nuclear Medicine Imaging Equipment Industry 11Global Nuclear Medicine Imaging Equipment Industry 12Global Nuclear Medicine Imaging Equipment Industry 13Global Nuclear Medicine Imaging Equipment Industry 14Global Nuclear Medicine Imaging Equipment Industry 15Global Nuclear Medicine Imaging Equipment Industry 16Global Nuclear Medicine Imaging Equipment Industry 17Global Nuclear Medicine Imaging Equipment Industry 18Global Nuclear Medicine Imaging Equipment Industry 19Global Nuclear Medicine Imaging Equipment Industry 20Global Nuclear Medicine Imaging Equipment Industry 21Global Nuclear Medicine Imaging Equipment Industry 22Global Nuclear Medicine Imaging Equipment Industry 23Global Nuclear Medicine Imaging Equipment Industry 24Global Nuclear Medicine Imaging Equipment Industry 25Global Nuclear Medicine Imaging Equipment Industry 26ROX Medical presents positive data for CONTROL-HTN resistant hypertension trial 2Improved risk identification will aid fertility preservation in young male cancer patients 2Improved risk identification will aid fertility preservation in young male cancer patients 3Improved risk identification will aid fertility preservation in young male cancer patients 4
... Cepheid (Nasdaq: CPHD ) today reported revenue for ... was $0.5 million, or $0.01 per share, which compares to ... million, or $(0.07) per share, in the first quarter of ... employee stock-based compensation expense, non-GAAP net income for the first ...
... 2011  Kinex Pharmaceuticals, LLC and Hanmi Pharmaceutical ... license agreement granting Hanmi Pharmaceuticals exclusive rights to ... in selected Asian Territories. KX01 (KX2-391) ... kinase/pretubulin dual mechanism inhibitor discovered and currently developed ...
Cached Medicine Technology:Cepheid Reports 2011 First Quarter Results 2Cepheid Reports 2011 First Quarter Results 3Cepheid Reports 2011 First Quarter Results 4Cepheid Reports 2011 First Quarter Results 5Cepheid Reports 2011 First Quarter Results 6Cepheid Reports 2011 First Quarter Results 7Cepheid Reports 2011 First Quarter Results 8Cepheid Reports 2011 First Quarter Results 9Hanmi Pharmaceuticals to Acquire the Rights for a Promising Phase II Anti-cancer Src Kinase/Pretubulin Dual Inhibitor from Kinex Pharmaceuticals, in Selected Asian Territories 2Hanmi Pharmaceuticals to Acquire the Rights for a Promising Phase II Anti-cancer Src Kinase/Pretubulin Dual Inhibitor from Kinex Pharmaceuticals, in Selected Asian Territories 3Hanmi Pharmaceuticals to Acquire the Rights for a Promising Phase II Anti-cancer Src Kinase/Pretubulin Dual Inhibitor from Kinex Pharmaceuticals, in Selected Asian Territories 4
ZyDoc offers a full medical transcription and documentation solution....
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
For the qualitative detection of single and multiple drugs and drug metabolites in human urine...
Medicine Products: