Navigation Links
Signal may send cancer's cellular factories into overdrive
Date:7/9/2014

A network of signals active in almost all types of cancer sends the protein factories in our cells into overdrive, and may help fuel a tumour's uncontrolled growth, new research suggests.

Scientists at The Institute of Cancer Research, London, identified a molecular trigger responsible for ratcheting up activity of the endoplasmic reticulum (ER) the cellular factory that makes the building blocks cancer cells need to keep growing.

A protein in the TOR signalling pathway, called SREBP, controls the flow of messages to the endoplasmic reticulum telling it to expand and could allow cancer cells to produce enough proteins and lipids to fuel their non-stop growth.

The findings may help to explain how cancer cells maintain their high levels of metabolism and could uncover future targets for cancer treatment.

The study was published in the journal PLOS ONE, and funded by the Biotechnology and Biological Sciences Research Council (BBSRC), with additional support from the Wellcome Trust.

Unlike healthy cells, cancer cells are constantly growing, and so need to keep making proteins and lipids - the building blocks of all cells.

In healthy cells constant growth can overwhelm cellular factories like the ER, leading to cell stress and death, but cancer cells manage to keep their factories running at high capacity to fuel non-stop growth.

Scientists at The Institute of Cancer Research (ICR) used the cells of fruit flies, modified with a fluorescent marker that is activated when the cells are put under stress, to identify the signals responsible for driving up activity of the ER.

They systematically silenced genes thought to be important to the smooth working of the ER and measured the stress signals produced in response.

They found that silencing the TOR signalling pathway - activated in many different types of cancer - increased ER stress in the cells. When they blocked TOR signals, cells took longer to recover from ER stress and the ER factory shrank.

Their findings suggest the TOR signalling pathway promotes cell growth while simultaneously ensuring productivity of the ER matches this growth. And the protein SREBP, which is part of the TOR signalling pathway, appeared to be essential for promoting expansion of the ER, and ensuring it carried out its factory activities effectively.

Lead author Dr Chris Bakal, leader of the Dynamical Cell Systems Team at The Institute of Cancer Research, London, said: "The endoplasmic reticulum is the factory of our cells, creating the proteins and lipids needed for our cells to grow and proliferate. In cancer cells, this factory is active all the time, churning out the building blocks that cancer cells need for their rapid growth.

"We have discovered the key role played by the TOR signalling pathway in driving the expansion of the endoplasmic reticulum, and sending a cell's factories into overdrive. The TOR pathway is active in many types of cancer, and our study provides new insights into how cancer metabolism works, and suggests that these metabolic signals could be excellent targets for future treatments."


'/>"/>
Contact: Graham Shaw
graham.shaw@icr.ac.uk
020-715-35380
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Related medicine news :

1. Signaling pathway may explain the body clocks link to mental illness
2. MAD: Scientists shed light on braking mechanisms in cellular signaling
3. Brain signals link physical fitness to better language skills in kids
4. Signals found that recruit host animals cells, enabling breast cancer metastasis
5. Nightmares may signal a child is being bullied
6. DNA modifications measured in blood signal related changes in the brain
7. Molecular aberration signals cancer
8. Tinnitus study signals advance in understanding link between loud sounds exposure and hearing loss
9. Long distance signals protect brain from viral infections
10. Prostate cancer signal reawakens sleeper agent cells in bones
11. App may signal cellphone dependency
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice ... "Film editors can give their videos a whole new perspective by using the ... of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to ...
(Date:6/25/2016)... , ... June 25, 2016 , ... ... policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at ... on several important health care topics including advance care planning, healthcare costs and ...
(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... ... Marcy was in a crisis. Her son James, eight, was out of control. Prone to ... , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there ... my other children and say he was going to kill them. If we were ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- MedSource announced today that it has selected Datatrial,s ... choice.  This latest decision demonstrates MedSource,s commitment to ... by offering a state-of-the-art electronic data capture (EDC) ... the EDC platform of choice in exchange for ... long been a preferred EDC platform by our ...
(Date:6/23/2016)... , June 23, 2016  In a startling report released ... failing their residents by lacking a comprehensive, proven plan to eliminate ... a definitive ranking of how states are tackling the worst drug ... only four states – Kentucky , ... Vermont . Of the 28 failing states, three – ...
(Date:6/23/2016)... , June 23, 2016 Research and ... News Issue 52" report to their offering. ... influenza treatment creates a favourable commercial environment for MedImmune to ... patient base that will serve to drive considerable growth for ... would serve to cap sales considerably, but development is still ...
Breaking Medicine Technology: