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Sigma-Aldrich Enters Distribution Agreement With AlphaGenix, Inc.
Date:11/13/2008

Sigma-Aldrich to Carry Key Products for Regenerative Medicine and Stem Cell

Biology Research

ST. LOUIS, Nov. 13 /PRNewswire-FirstCall/ -- Sigma-Aldrich (Nasdaq: SIAL) today announced a distribution agreement with AlphaGenix, Inc., a leading developer and manufacturer of products for basic and clinical life science research. Sigma-Aldrich will now be the exclusive supplier of AlphaGenix-developed antibodies and research tools for the fields of regenerative medicine and stem cell biology. This partnership will further augment Sigma-Aldrich's growing product portfolio of life science tools for stem cell research (http://www.sigma-aldrich.com/stemcell).

The new product offerings include antibodies to stem cell markers; tools for 3-D stem cell culture systems, such as MaxGel(TM), a human derived extracellular Matrix (ECM) and its components; and HydroMatrix(TM), a synthetic peptide scaffold that offers the precision and control of a synthesized matrix with the natural 3-D architecture of a highly crosslinked peptide hydrogel.

Over the past decade, researchers have developed a number of enhanced 3-D cell culture systems that better resemble in vivo systems. Both MaxGel and HydroMatrix promote cell growth and migration and have been shown to support the proliferation and enhance function of many cell types, including neural stem cells, neurons, glia, astrocytes, fibroblasts, and keratinocytes.

"It is increasingly important to design cell culture assays that closely mimic the behavior of cells in living tissues," said Carl Schrott, Director of Marketing for Regenerative Medicine and Research Cell Culture at Sigma-Aldrich. "Through this partnership, we will offer our customers new tools to grow stem cells that resemble their in vivo counterparts, and the high-quality antibodies needed to study them."

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