Navigation Links
Side effects of hormonal breast cancer therapy increased; may affect treatment adherence
Date:11/9/2010

PHILADELPHIA Women being treated for breast cancer with aromatase inhibitors may experience extremely low estrogen levels resulting in a wide variety of side effects that a typical postmenopausal woman without cancer may not experience.

Data presented at the Ninth Annual AACR Frontiers in Cancer Prevention Conference, held here Nov. 7-10, 2010, showed that women assigned to take aromatase inhibitors had increases in side effects such as hot flashes, decreased appetite, fatigue, fever, breast sensitivity, etc.

"Aromastase inhibitors represent one of the most major advances in breast cancer treatment," said Lisa Gallicchio, Ph.D., an epidemiologist at The Prevention and Research Center at Mercy Medical Center, Baltimore. "Their incorporation into the breast cancer treatment armamentarium has led to impressive reductions in breast cancer recurrence and mortality rates.

"Despite this, many breast cancer patients stop taking their aromatase inhibitor treatment which is usually prescribed for five years or do not adhere to their treatment prescription," she said, adding that this may be due to, at least in part, the side effects associated with the drugs.

To better define the full spectrum of side effects associated with aromatase inhibitor treatment, Gallicchio and colleagues surveyed 100 women with breast cancer who were about to start treatment with aromatase inhibitors. Their side effects were compared with those of 200 similarly-aged women without a history of breast cancer.

Questionnaires about symptoms were completed prior to treatment initiation by women with breast cancer and at the start of the study for the healthy women. Women were followed for six months and completed additional questionnaires at three months and at the completion of the study.

Women taking aromatase inhibitors were five times more likely to report having hot flashes, breast sensitivity and chest pain than healthy women. In addition, they were four times more likely to report night sweats, cold sweats and hair loss and about three times more likely to report leg cramps, weight gain, sleep disturbance, tendency to take naps and forgetfulness. Other increased symptoms included intestinal gas, cough, depression, interrupted sleep and irritability.

"We know that aromatase inhibitors are effective in treating breast cancer," Gallicchio said. "Knowing the side effects of aromatase inhibitor treatment and how to treat them is critical for keeping women on their aromatase inhibitor treatment and improving their chances of surviving and living cancer free."


'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Drug May Ease Cognitive Effects of Huntingtons
2. YazTalk Warns Women of Life Threatening Side Effects
3. ACR, SBI: Avon Survey Reveals Potentially Deadly Effects of USPSTF Mammography Recommendations
4. Prozac and Celexa exhibit anti-inflammatory effects
5. Lung cancer research explores the effects of patient attitudes on patient outcomes
6. Increased radiation dose does not increase long-term side effects for prostate cancer patients
7. Prostate Cancer Radiation Side Effects May Subside With Time
8. ASTRO publishes supplement on protecting cancer patients by reducing radiation doses, side effects
9. Scans of brain networks may help predict injurys effects
10. Most women facing gynecologic surgery dont worry about its effects on sex
11. Adverse drug effects in epileptic patients not correlated with number of prescribed medications
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... Virginia (PRWEB) , ... March 23, 2017 , ... ... public health services to their communities, 16 more public health departments have been ... week’s decisions bring another 4.5 million people into the expanding network of communities ...
(Date:3/23/2017)... , ... March 23, 2017 , ... 82% of adults are unaware of the dangers ... not brush their teeth the minimum two times a day that dentists recommend. The ramifications ... 51 million hours of school and adults missing 164 million hours of work each year ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... ... investment in Los Angeles based healthcare technology company California Healthcom Group (CHG). ... the US, and healthcare arena. With headquarters in California, CHG is a growing, ...
(Date:3/23/2017)... ... ... After raising more than $1.135 million ($1,479,231 AUD) from nearly 20,000 backers ... crowdfunding history, has established a U.S. Headquarters in New York City, FaceCradle USA, LLC, ... excited to be operating on U.S. shores, where most of our initial crowdfunding backers ...
(Date:3/23/2017)... ... ... According to the National Sleep Foundation , poor sleep quality affects ... of the sunken-eye look, which can include dark circles or bags under the eyes. ... likely due to genetics, dehydration, allergies, and losing fat beneath the thin skin under ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... DENVER , March 23, 2017  Drug ... pain medication misuse and deadly overdoses. A new ... Health Solutions, www.cordantsolutions.com , reports more detailed ... tests, which can potentially improve therapy adherence, patient ... The Cordant Comprehensive Oral fluid Rx Evaluation ...
(Date:3/23/2017)... , March 23, 2017  A new genetic ... accurate identification of individuals who carry HLA-B*15:02 ... a rare yet potentially deadly side effect of ... disorder.  The gene HLA-B*15:02 is strongly ... as Stevens-Johnson syndrome and toxic epidermal necrolysis in ...
(Date:3/23/2017)... ALBANY, New York , March 23, 2017 ... devices market exhibits a consolidated vendor landscape with the ... the overall market in 2015. These companies are ... Industries, Inc., Hygia Health Services, Inc., and VANGUARD ... global reprocessed medical devices market is witnessing the ...
Breaking Medicine Technology: