Navigation Links
Side Effects in Statin Users Linked to Gene Mutation
Date:10/14/2009

Finding may help tailor treatments to keep patients from stopping meds, researcher says

WEDNESDAY, Oct. 14 (HealthDay News) -- U.S. researchers have identified a common gene mutation linked to side effects in people taking cholesterol-lowering statin drugs.

Statins can reduce high cholesterol and lower the risk of heart attack or stroke. But 25 percent to 50 percent of people prescribed the potentially lifesaving drugs stop taking them after a year because of side effects, in particular muscle aches.

The study included 509 people taking one of three types of statins: atorvastatin (Lipitor), simvastatin (Zocor) or pravastatin (Pravachol). The patients took the drugs for an initial period of eight weeks and then had their doses increased for an additional eight weeks.

The Duke University Medical Center researchers found that people with the common mutation in the SLCO1B1 gene were more likely to have muscle aches. The more copies of the mutation, the greater their risk.

The study also found that the muscle side effects differed depending on the type of statin. People taking simvastatin reported the most side effects while those taking pravastatin had the least muscle aches.

The findings, published online Oct. 12 in the Journal of the American College of Cardiology, may help doctors increase the number of patients who keep taking the drugs.

"If a genetic test can be developed to determine who will experience side effects that will likely make patients go off their medication, we can target these individuals for counseling about common side effects, monitor them more closely or tailor their medication accordingly," lead author and cardiologist Dr. Deepak Voora said in a Duke news release.

More information

The U.S. Food and Drug Administration has more about statins.



-- Robert Preidt



SOURCE: Duke Medicine, news release, Oct. 12, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Beneficial effects of alcohol?
2. News brief: Effects of aspirin and folic acid on inflammation markers for colorectal adenomas
3. GTRI is developing protocols for testing effects of RFID systems on medical devices
4. Smoking bans effects on heart disease risks -- IOM report releases Oct. 15
5. Largest Survey of Its Kind Finds the Psychological and Social Effects of Psoriasis Greater for Women
6. Mayo researchers find few side effects from radiation treatment given after prostate cancer surgery
7. Penn studies point to strategies for reducing painful breast cancer drug side effects
8. Many Kids Suffer Medication Side Effects: Study
9. After-Effects of Chemotherapy May Include Memory Problems
10. Treating Childhood Leukemia With Fewer Side Effects
11. Yeast unravels effects of chemotherapy drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2017)... ... 2017 , ... The National Business Research Institute (NBRI) is ... Emergency Medical Technicians and welcomes this organization to the NBRI Circle of ... Ph.D. , CEO & Organizational Psychologist at NBRI. “This award is a result ...
(Date:4/26/2017)... , ... April 26, 2017 , ... ... today launched a unique website ( CRISPRCas.pioneer.com ) that demonstrates how this advanced ... farmers produce more and better food, with fewer resources. It highlights the business’ ...
(Date:4/25/2017)... ... April 25, 2017 , ... Bellus Medical, a ... first in a new class of photodynamic cosmetics (PDC). , Allumera® is the ... reduce outward signs of aging, and minimize the appearance of pores – all ...
(Date:4/25/2017)... , ... April 25, 2017 , ... A stressful work ... work can also decrease overall productivity and performance in the workplace. The goal of ... During the last few weeks of April, Clearview Resolution Services will be shutting down ...
(Date:4/25/2017)... ... ... Lake Park Dental is now accepting new patients with crooked teeth who ... the help of this highly-effective, yet convenient system, patients can straighten their teeth and ... pain. , Drs. Sarah Jockin, Nicole Morganti, Sara Spear and Elizabeth Dy, of ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... , April 20, 2017 Research ... "Global Biosimilar Pipeline and Market Prospects: Addressing Production Complexities ... to their offering. ... "Global Biosimilar Pipeline and Market Prospects: Overcoming ... provides an in-depth assessment of the current trends in ...
(Date:4/20/2017)... , April 20, 2017   ZappRx, Inc ., a ... drug prescribing process, today announced it closed $25 million in ... venture capital firm based in Seattle ... Venture Partners . The Series B round included participation from ... in 2014, and GV (formerly Google Ventures). As ...
(Date:4/20/2017)... , April 20, 2017 NeuroVive Pharmaceutical ... today announced positive preclinical results demonstrating anti-fibrotic ... for non-alcoholic steatohepatitis (NASH), in an additional ... NV556 has previously shown similar anti-fibrotic ... Today, NeuroVive,s scientists present novel data demonstrating ...
Breaking Medicine Technology: