Navigation Links
Side Effects in Statin Users Linked to Gene Mutation
Date:10/14/2009

Finding may help tailor treatments to keep patients from stopping meds, researcher says

WEDNESDAY, Oct. 14 (HealthDay News) -- U.S. researchers have identified a common gene mutation linked to side effects in people taking cholesterol-lowering statin drugs.

Statins can reduce high cholesterol and lower the risk of heart attack or stroke. But 25 percent to 50 percent of people prescribed the potentially lifesaving drugs stop taking them after a year because of side effects, in particular muscle aches.

The study included 509 people taking one of three types of statins: atorvastatin (Lipitor), simvastatin (Zocor) or pravastatin (Pravachol). The patients took the drugs for an initial period of eight weeks and then had their doses increased for an additional eight weeks.

The Duke University Medical Center researchers found that people with the common mutation in the SLCO1B1 gene were more likely to have muscle aches. The more copies of the mutation, the greater their risk.

The study also found that the muscle side effects differed depending on the type of statin. People taking simvastatin reported the most side effects while those taking pravastatin had the least muscle aches.

The findings, published online Oct. 12 in the Journal of the American College of Cardiology, may help doctors increase the number of patients who keep taking the drugs.

"If a genetic test can be developed to determine who will experience side effects that will likely make patients go off their medication, we can target these individuals for counseling about common side effects, monitor them more closely or tailor their medication accordingly," lead author and cardiologist Dr. Deepak Voora said in a Duke news release.

More information

The U.S. Food and Drug Administration has more about statins.



-- Robert Preidt



SOURCE: Duke Medicine, news release, Oct. 12, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Beneficial effects of alcohol?
2. News brief: Effects of aspirin and folic acid on inflammation markers for colorectal adenomas
3. GTRI is developing protocols for testing effects of RFID systems on medical devices
4. Smoking bans effects on heart disease risks -- IOM report releases Oct. 15
5. Largest Survey of Its Kind Finds the Psychological and Social Effects of Psoriasis Greater for Women
6. Mayo researchers find few side effects from radiation treatment given after prostate cancer surgery
7. Penn studies point to strategies for reducing painful breast cancer drug side effects
8. Many Kids Suffer Medication Side Effects: Study
9. After-Effects of Chemotherapy May Include Memory Problems
10. Treating Childhood Leukemia With Fewer Side Effects
11. Yeast unravels effects of chemotherapy drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2016)... ... 2016 , ... Just in time for the holiday season, the celebrated paleo ... for Honeyville’s new Organic Quinoa Flour product for sale at Costco stores throughout the ... , “I think it’s wonderful that a growing number of retailers such as ...
(Date:12/6/2016)... ... December 06, 2016 , ... ... SevenPoint2 released the much-anticipated HydroFX for Water®. This first-of-its-kind water-soluble powder supplement ... of the world’s most powerful antioxidants, molecular hydrogen, HydroFX for Water transforms ...
(Date:12/6/2016)... ... December 06, 2016 , ... ... of a powerful woman's story of sacrifice and enlightenment. , “Tatiana ... author, Carolyn Fryer. Always looking for creative outlets, Carolyn gravitated toward writing through ...
(Date:12/6/2016)... ... December 06, 2016 , ... The OSHA Training Center ... Education Center headquartered in Northern California, has announced the addition of a Public ... health training to public sector employees. , “The primary goal of the Public ...
(Date:12/5/2016)... ... 05, 2016 , ... What: Shriners Hospitals for Children, with the help of ... – using a video monitor and web-enabled camera. Santa visits with children through Dimension ... a Christmas Wonderland, which is where the video connection to the North Pole will ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... , Nov. 29, 2016 Several leading ... by Accera, Inc. at 11 a.m. EST ... International Conference on Clinical Trials for Alzheimer,s Disease (CTAD). ... metabolism in Alzheimer,s disease and therapeutic targets that address ... "Following the recent failure of another therapy targeting ...
(Date:12/5/2016)... DUBLIN , Dec 5, 2016 ... Blotting Market by Product (Instruments, Consumables), Application (Biomedical & Biochemical Research, ... Companies) - Global Forecasts to 2021" report to their offering. ... , , ... reach USD 730.7 Million in 2021 from USD 574.8 Million in ...
(Date:12/5/2016)... and PUNE, India , December 5, 2016 /PRNewswire/ ... titled, "Surgical Sutures Market by Product Type and by Application - Global Opportunity ... for $3,360 million in 2015, and is expected to reach $5,255 million by ... segment dominated the market in 2015 with more than four-fifths share. ... ...
Breaking Medicine Technology: