Navigation Links
Side Effects May Spur Men to Drop Tamoxifen for Breast Cancer
Date:11/16/2011

WEDNESDAY, Nov. 16 (HealthDay News) -- One in five male breast cancer patients stops taking the drug tamoxifen early due to side effects caused by the medicine and may be at increased risk for cancer recurrence, new research suggests.

Tamoxifen is the standard of care for the hormone treatment of male breast cancer patients, according to the authors of a new report published in the Nov. 16 issue of the Annals of Oncology.

In the study, researchers at the University of Texas M.D. Anderson Cancer Center in Houston examined the records of 64 male breast cancer patients who received tamoxifen for an average of four years and found that 34 of them (53 percent) experienced one or more tamoxifen-related side effects, such as weight gain and loss of sex drive.

Thirteen (20.3 percent) of the patients stopped taking tamoxifen due to the side effects. Nine of the patients died after they discontinued tamoxifen early, the study authors noted in a journal news release.

"This is the largest study to specifically assess tamoxifen-related side effects in men because in our institution we treated a relatively large number of male breast cancer patients," study author Dr. Naveen Pemmaraju said in the news release.

"We found that, after adjusting for patient age and stage of the disease, the prognosis for men with breast cancer is similar to that of women. Tamoxifen has been shown to improve survival rates for breast cancer patients, so early discontinuations may have the potential to increase the risk of the cancer recurring in this group of male breast cancer patients," he added.

"Male breast cancer is a very rare and unique cancer affecting approximately 2,000 men in the U.S.A. per year. As there are so few male breast cancer cases, clinical practice and optimal treatment strategies have been extrapolated from female breast cancer patients with very little published evidence to guide clinical decisions. In our institution, we noted that several of our male patients were having difficulty with taking tamoxifen therapy, and these side effects appeared to be a little bit different to those reported with women receiving the same drug," Pemmaraju continued.

"The results of this study should not change the recommendation for prescribing tamoxifen for male breast cancer patients. However, clinicians need to be aware of the possible side effects that men may experience when receiving tamoxifen so that the patients can be counseled appropriately," he added.

In the United States, about 2,140 new cases of invasive breast cancer in men will be diagnosed this year and about 450 men will die of the disease.

More information

The U.S. National Cancer Institute has more about male breast cancer.

-- Robert Preidt

SOURCE: Annals of Oncology, news release, Nov. 15, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Drug May Ease Cognitive Effects of Huntingtons
2. YazTalk Warns Women of Life Threatening Side Effects
3. ACR, SBI: Avon Survey Reveals Potentially Deadly Effects of USPSTF Mammography Recommendations
4. Prozac and Celexa exhibit anti-inflammatory effects
5. Lung cancer research explores the effects of patient attitudes on patient outcomes
6. Increased radiation dose does not increase long-term side effects for prostate cancer patients
7. Prostate Cancer Radiation Side Effects May Subside With Time
8. ASTRO publishes supplement on protecting cancer patients by reducing radiation doses, side effects
9. Scans of brain networks may help predict injurys effects
10. Most women facing gynecologic surgery dont worry about its effects on sex
11. Adverse drug effects in epileptic patients not correlated with number of prescribed medications
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Side Effects May Spur Men to Drop Tamoxifen for Breast Cancer
(Date:2/11/2016)... ... February 11, 2016 , ... ... ergoFET force gauges used in physical therapy, occupational therapy and sports medicine clinics, ... resistance cord exercise and therapy, introduces its new microFET Digital Pinch Gauge. ...
(Date:2/11/2016)... ... , ... As part of their 2015 end of year funding strategy, ... has gifted $10,000 to University of Chicago to support ovarian cancer research being conducted ... are honored to support a promising young investigator from Dr. Lengyel’s lab at the ...
(Date:2/10/2016)... ... 10, 2016 , ... LaserShip, a regional parcel carrier that services the eastern ... Michigan last Friday in order to aid in the Flint water crisis. In 2014, ... facility located in Clio, only 15 miles away from Flint. , “We have deep ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... Remote Interpreting (VRI) within Healthcare, recently partnered with Heart City Health Center ... , For nearly 23 years, Heart City Health Center has provided the Elkhart ...
(Date:2/10/2016)... ... February 10, 2016 , ... 10 Best Water is excited ... bottled water brand owners that topped the list as a result of their commitment ... The premier brand was Tibet 5100, a top notch water company that specializes in ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... YORK , Feb. 11, 2016  Today, ... foot-focused suite of products designed to support health ... are custom orthotic insoles that combine years of ... partners in the podiatric field with cutting edge ... and propel . It is supported by SOLS, ...
(Date:2/11/2016)... --> ... report provides information on development trends, competitive landscape ... statistical data and information analysis. http://www.deepresearchreports.com/142870.html ... Complete report on Autoclave industry spread across ... 296 tables and figures is now available at ...
(Date:2/10/2016)... Calif., Feb. 10, 2016   Genomic Health, Inc. (Nasdaq: ... the quarter and year ended December 31, 2015. ... fourth quarter of 2015, compared with $69.1 million in the fourth ... currency basis, revenue increased 9 percent compared with the same period ... U.S. revenue was $63.9 million in the fourth quarter of ...
Breaking Medicine Technology: