Navigation Links
Side Effects May Spur Men to Drop Tamoxifen for Breast Cancer
Date:11/16/2011

WEDNESDAY, Nov. 16 (HealthDay News) -- One in five male breast cancer patients stops taking the drug tamoxifen early due to side effects caused by the medicine and may be at increased risk for cancer recurrence, new research suggests.

Tamoxifen is the standard of care for the hormone treatment of male breast cancer patients, according to the authors of a new report published in the Nov. 16 issue of the Annals of Oncology.

In the study, researchers at the University of Texas M.D. Anderson Cancer Center in Houston examined the records of 64 male breast cancer patients who received tamoxifen for an average of four years and found that 34 of them (53 percent) experienced one or more tamoxifen-related side effects, such as weight gain and loss of sex drive.

Thirteen (20.3 percent) of the patients stopped taking tamoxifen due to the side effects. Nine of the patients died after they discontinued tamoxifen early, the study authors noted in a journal news release.

"This is the largest study to specifically assess tamoxifen-related side effects in men because in our institution we treated a relatively large number of male breast cancer patients," study author Dr. Naveen Pemmaraju said in the news release.

"We found that, after adjusting for patient age and stage of the disease, the prognosis for men with breast cancer is similar to that of women. Tamoxifen has been shown to improve survival rates for breast cancer patients, so early discontinuations may have the potential to increase the risk of the cancer recurring in this group of male breast cancer patients," he added.

"Male breast cancer is a very rare and unique cancer affecting approximately 2,000 men in the U.S.A. per year. As there are so few male breast cancer cases, clinical practice and optimal treatment strategies have been extrapolated from female breast cancer patients with very little published evidence to guide clinical decisions. In our institution, we noted that several of our male patients were having difficulty with taking tamoxifen therapy, and these side effects appeared to be a little bit different to those reported with women receiving the same drug," Pemmaraju continued.

"The results of this study should not change the recommendation for prescribing tamoxifen for male breast cancer patients. However, clinicians need to be aware of the possible side effects that men may experience when receiving tamoxifen so that the patients can be counseled appropriately," he added.

In the United States, about 2,140 new cases of invasive breast cancer in men will be diagnosed this year and about 450 men will die of the disease.

More information

The U.S. National Cancer Institute has more about male breast cancer.

-- Robert Preidt

SOURCE: Annals of Oncology, news release, Nov. 15, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Drug May Ease Cognitive Effects of Huntingtons
2. YazTalk Warns Women of Life Threatening Side Effects
3. ACR, SBI: Avon Survey Reveals Potentially Deadly Effects of USPSTF Mammography Recommendations
4. Prozac and Celexa exhibit anti-inflammatory effects
5. Lung cancer research explores the effects of patient attitudes on patient outcomes
6. Increased radiation dose does not increase long-term side effects for prostate cancer patients
7. Prostate Cancer Radiation Side Effects May Subside With Time
8. ASTRO publishes supplement on protecting cancer patients by reducing radiation doses, side effects
9. Scans of brain networks may help predict injurys effects
10. Most women facing gynecologic surgery dont worry about its effects on sex
11. Adverse drug effects in epileptic patients not correlated with number of prescribed medications
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Side Effects May Spur Men to Drop Tamoxifen for Breast Cancer
(Date:5/2/2016)... ... 2016 , ... Atlantic Information Services, Inc. (AIS) is pleased to announce its ... the Pharma Landscape .” CMS recently proposed a test of alternate payment models for ... preserving care provided to beneficiaries. The webinar will review the details of this model, ...
(Date:5/2/2016)... ... May 02, 2016 , ... The Evolve Paddle Board Company- which specializes ... today the outcome of their partnership with Yoloha Yoga- producers of high quality cork ... , SUP yoga has seen a dramatic rise in popularity throughout the last few ...
(Date:5/2/2016)... TN (PRWEB) , ... May 02, 2016 , ... ... and behavioral health services, today announced the opening of Twin Lakes Recovery Center. ... will be Summit’s first in the state. The residential facility is set ...
(Date:5/2/2016)... CA (PRWEB) , ... May 02, 2016 , ... ... offering regenerative therapy, which includes amniotic fluid/“stem cells” and Platelet Rich Plasma (PRP) ... athletes and celebrities,” said Dr. James Baranski, D.C., of Advanced Spine & Sport ...
(Date:5/1/2016)... ... May 01, 2016 , ... Women’s Excellence ... new mothers a better understanding of what to expect after they deliver. The ... baby postpartum, · The blues and depression, · Breastfeeding beyond postpartum · Baby ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... , April 29, 2016 ... glyco-biology expertise, today announces the appointment of Dr. ... Dr. Zurlo is an oncologist with many years clinical ... and biotechnology industries. His last role was at Mologen ... of the Executive Board. Previously Dr. Zurlo held various ...
(Date:4/28/2016)... BURLINGAME, Calif. , April 28, 2016 /PRNewswire/ ... first-ever widely accessible breast and ovarian cancer risk ... cancer panel analyzing 30 genes that highly impact ... and women. Available today, the Color Test analyzes ... pancreatic, prostate, stomach, and uterine cancers. The Color ...
(Date:4/28/2016)... April 28, 2016 Dr. Vivek ... and Ste phen Schmidt ... a leading provider of cloud-based software solutions for life sciences, today ... to bring a wealth of insight to a growing business.  This ... George Phillips joined ArisGlobal in the position ...
Breaking Medicine Technology: