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Sickle cell project named among 'Top 10' Clinical Research Achievements for 2012
Date:4/19/2013

he Johns Hopkins investigators also developed a protocol that prepared patients for the donor marrow by administering low-dose immunosuppression drugs, low toxicity-chemotherapy, and low-dose total body irradiation. This "gentler" approach, Brodsky says, makes the process more tolerable for patients whose tissues and organs have been compromised by sickle cell disease. Post-transplant, patients received high doses of chemotherapy to kill off any remaining original blood cells (including diseased sickled cells), while preserving the stem cells that make new, healthy blood cells.

Brodsky also sees the potential for using the half-matched donor approach for people with autoimmune disorders such as lupus and multiple sclerosis. It makes sense, he says, that a brand-new immune system would resolve the underlying problem causing their medical condition. "I think you're going to see newer indications [for these half-match BMTs] more often for nonmalignant diseases than malignant ones, for which bone marrow transplants were first developed," Brodsky says. "That's really the next new frontier."


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Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine
Source:Eurekalert

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