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Sickle cell project named among 'Top 10' Clinical Research Achievements for 2012
Date:4/19/2013

Pioneering research led by Johns Hopkins scientists on the use of partially matched bone marrow transplants to wipe out sickle cell disease has been selected as one of the Top 10 Clinical Research Achievements of 2012 by the Clinical Research Forum. The success of a preliminary clinical trial of the so-called haploidentical transplants has the potential to bring curative transplants to a majority of sickle cell patients who need them, eliminating painful and debilitating symptoms and the need for a lifetime of pain medications and blood transfusions.

On behalf of the research team, Robert A. Brodsky, M.D., the Johns Hopkins Family Professor of Medicine in Oncology and director of the Division of Hematology at the Johns Hopkins University School of Medicine, will receive the award and an additional honor, the Distinguished Clinical Research Achievement Award, at a ceremony on April 18 during the Clinical Research Forum annual meeting in Washington, D.C.

Comprised of academic medical centers, professional organizations, and industry partners, the Clinical Research Forum selects 10 scientists each year whose clinical research improves human health and alleviates suffering from disease. All research projects honored this year were published in 2012 and funded by various federal agencies, foundations, and corporations. In addition to Brodsky's work, others on the Top 10 list in 2012 included studies of a treatment that restores sight, the use of sophisticated prosthetic devices to alleviate paralysis from neurological illnesses, and replacement of defective heart valves without open heart surgery.

Brodsky's study, reported online September 6, 2012 in the journal Blood, showed that, of 17 sickle cell disease patients offered bone marrow transplants (BMT), 11 transplants were successful. Eight of those successful transplants involved patients who received half-matched, rather than fully matched donor marrow. Three received fully match
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Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine
Source:Eurekalert

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