Navigation Links
Sickle Cell Disease Tied to 'Silent Strokes' in Children
Date:12/2/2011

FRIDAY, Dec. 2 (HealthDay News) -- Children with sickle cell disease, an inherited blood disorder, who also have high blood pressure and/or anemia are at increased risk for so-called "silent strokes," according to a new study.

Silent strokes, which cause no symptoms, "are typically seen in older adults, and these findings give us additional insight into why they tend to occur so often in children with sickle cell disease," senior study investigator Dr. James Casella, director of hematology at Johns Hopkins Children's Center, said in a center news release.

Casella and his colleagues performed MRI brain scans on 814 children with sickle cell disease, aged 5 to 15, and found that 31 percent of them had suffered silent strokes. None of the children had a history of strokes or seizures, and none showed any signs of stroke at the time of the study.

After examining the children's medical histories, the researchers concluded that anemia and high blood pressure individually increased the risk of silent stroke in the study participants, but the combination of the two carried the highest risk.

Among these sickle cell patients, those with the highest systolic blood pressure (the top number in their blood pressure reading) was above 113 and the lowest hemoglobin (below 7.6 grams per deciliter) had a nearly four times greater risk of silent stroke than those with the lowest blood pressure and highest hemoglobin. Hemoglobin is the protein in red blood cells that carries oxygen. Anemia is defined by low levels of hemoglobin.

Compared to children with the lowest blood pressure readings, those with the highest blood pressure had a 1.7 times greater risk of silent stroke. And the risk was more than doubled for kids with the lowest hemoglobin levels versus kids with the highest hemoglobin levels, the investigators found.

The researchers said their findings highlight the need to identify children with sickle cell disease who have early signs of anemia and high blood pressure, both of which are modifiable risk factors. The findings may also lead to new treatments for sickle cell disease.

The study was published online Nov. 17 in the journal Blood.

While extremely rare in children overall, stroke is a common complication in children with sickle cell disease. Nearly 100,000 people in the United States have sickle cell disease. The disease, inherited from both parents, causes red blood cells to take the shape of crescents or sickles, and results in less oxygen being delivered to the body's tissues. These fragile cells can interrupt blood flow when they get stuck in small blood vessels. Patients with sickle cell disease require ongoing treatment, according to the U.S. National Institutes of Health, which funded the study.

More information

The Nemours Foundation has more about sickle cell disease.

-- Robert Preidt

SOURCE: Johns Hopkins Children's Center, news release, Nov. 28, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Study identifies silent stroke risk factors for children with sickle cell anemia
2. Researchers reveal potential treatment for sickle cell disease
3. Correcting sickle cell disease with stem cells
4. Sickle cell trait is not risk factor for kidney disease
5. Schools failing pupils with sickle cell disease
6. Nitric oxide impacts source of sickle cell pain crisis
7. ENERCA clinical recommendations for sickle cell disease management and prevention in children
8. Young black athletes with sickle cell trait might be susceptible to sudden death
9. Sickle Cell May Be Hidden Danger to Young Athletes
10. 2 studies provide insight into stroke risk and prevention in young sickle cell anemia patients
11. Georgia Tech hosts sickle cell disease symposium
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sickle Cell Disease Tied to 'Silent Strokes' in Children
(Date:3/23/2017)... ... March 23, 2017 , ... GeBBS Healthcare ... Assurance, at HCCA’s 21st annual Compliance Institute on March 26-28 in National Harbor, ... for all medical chart types with a comprehensive set of features including built-in ...
(Date:3/23/2017)... ... ... Woman Be Ye Healed-Passing On A Legacy”: a call to heal the wounded Church. ... author, Desiree M Webb, a registered nurse, minister of music, speaker, songwriter, recording artist, ... husband, Paul, for over twenty-nine years. Desiree enjoys writing, beach trips, ministering in ...
(Date:3/23/2017)... , ... March 23, 2017 , ... ... the existence of God. “A Respectful Response To Atheist Manifesto” is the creation ... married to his wife, Nancy, for sixty years. He holds graduate degrees from ...
(Date:3/23/2017)... ... March 23, 2017 , ... Vortex Biosciences, provider ... protein expression in circulating tumor cells using microfluidic western blotting” in Nature Communications ... Vortex technology to capture CTCs and a microfluidic single-CTC resolution Western ...
(Date:3/22/2017)... ... March 23, 2017 , ... Catalent Pharma Solutions, ... biologics and consumer health products, today announced that it had won the ‘Clinical ... at the Suntec Singapore International Exhibition & Convention Centre, Singapore. The award was ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... , March 23, 2017 ... Piramal Enterprises Limited, gibt die Ernennung von ... PPS bietet seinen globalen Pharmazeutikkunden eine einmalige ... eine wichtige Rolle für das erfolgreiche Wachstum ... kaufmännischer Leiter wird Herr Needleman dafür verantwortlich ...
(Date:3/23/2017)... March 23, 2017 Pre-market today, Stock-Callers.com ... PLC (NYSE: AGN), Horizon Pharma PLC (NASDAQ: HZNP), and Evoke ... stocks are part of the Healthcare sector, which was slightly ... 2017, with the NYSE Health Care Index adding about 0.1% ... S&P 500 also were up nearly 0.1% as a group. ...
(Date:3/23/2017)... 23, 2017 AbbVie, a global biopharmaceutical company, ... Julianne Hough is helping to raise awareness ... Know about ME in EndoMEtriosis . "   The ... to learn about and understand endometriosis, a disease affecting ... to address their symptoms with a healthcare professional.  Despite ...
Breaking Medicine Technology: