Navigation Links
Sickle Cell Disease Tied to Cognitive Difficulties
Date:5/11/2010

Lowered blood oxygen levels may be to blame, researchers say

TUESDAY, May 11 (HealthDay News) -- Adults with sickle cell anemia are at increased risk for neurocognitive problems, which can affect their ability to cope with daily tasks such as work, managing their finances, taking medications, use of community resources, and socializing, a new study finds.

The research included 149 patients with sickle cell anemia (SCA), ages 19 to 55, and a control group of 47 healthy people. Both groups underwent MRI brain scans and tests of neuropsychological function.

Compared to the control group, the SCA patients had statistically significant lower average nonverbal function scores, and lower average scores for measures of processing speed, working memory, global cognitive function (which includes learning, memory and attention processes), and most measures of executive function (which includes the ability to control behavior, anticipate outcomes, adapt to change and make appropriate decisions).

The MRI scans revealed no brain structure differences between the sickle cell anemia patients and the controls. The neurocognitive problems in SCA patients appear to be due to anemia and age, the researchers said.

Adult patients with SCA who do not show symptoms of reasoning and thinking deficits are still at risk for problems in those areas, because their anemia may be causing cognitive impairment as a result of deficient oxygen in the blood that is undetectable by standard neuroimaging studies, according to Dr. Elliott P. Vichinsky, of Children's Hospital & Research Center in Oakland, Calif., and colleagues.

"Several practical steps can be taken. First, early identification of patients with difficulties on specific measures of neurocognitive function may allow these patients to enroll in and benefit from cognitive rehabilitation programs. Additionally, longitudinal studies are necessary to understand and evaluate disease progression. These studies can be linked to biological components to improve understanding of neurocognitive function in SCA," the researchers wrote.

The study appears in the May 12 issue of the Journal of the American Medical Association.

More information

The U.S. National Heart, Lung, and Blood Institute has more about sickle cell anemia.



-- Robert Preidt



SOURCE: Journal of the American Medical Association, news release, May 11, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Blood stem-cell transplant regimen reverses sickle cell disease in adults
2. Bone Marrow Transplants May Cure Sickle Cell in Adults
3. Cholesterol-Lowering Drug Shows Promise Against Serious Infections in Sickle Cell Disease
4. Statins Show Promise Against Sickle Cell
5. New approach to sickle-cell disease shows promise in mice
6. Swine Flu Can Batter Kids With Sickle Cell
7. New study finds barriers to pain treatment in children with sickle cell disease
8. Studies Investigate Emerging Trends and Treatment Options for Patients With Sickle Cell Disease
9. Sickle Cell Disease Patients Seek Acute Pain Care Repeatedly
10. Low blood oxygen may lead to heart defects in children with sickle cell disease
11. New research identifies modifiable risk factors for heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/23/2017)... (PRWEB) , ... February 23, 2017 , ... ... pre-eminent publication and community for those in the fight against cancer, has produced ... in their success. HRA will release top-line findings in a webinar, Defining ...
(Date:2/23/2017)... ... 2017 , ... CALNOC, the nation’s first and only nursing quality indicators database ... Empowerment, Value and Collaboration – in Seattle, WA on October 23, 2017. , Dr. ... System in Seattle since 2000. In addition to his role at Virginia Mason, Dr. ...
(Date:2/23/2017)... ... February 23, 2017 , ... HealthPostures, the desk for standing ... sit stand solutions representative to the Minneapolis Home and Garden Show which is being ... that is garnering national attention is the Minneapolis Convention Center. , From its ...
(Date:2/22/2017)... ... February 22, 2017 , ... When it ... healthcare contact center in Georgia, PENETRON Specialty Products (PSP) provided the solution. January’s ... systems recently invested $51 million to purchase and renovate the 185,000 square-foot office ...
(Date:2/22/2017)... ... February 22, 2017 , ... Stem cell ... years. The technology is so cutting edge, in fact, the U.S. Food and ... cell procedures. However, successful patient outcomes in certain clinical stem cell procedures have ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)...  As National Nutrition Month approaches, USA Medical is ... helping people live healthier lives by providing discounts ... in all 50 states including:  Texas Prescription Assistance ... Prescription Assistance Program . USA Medical also ... for nutritious eating habits: ...
(Date:2/23/2017)... , February 23, 2017 On ... of day as four out of nine sectors finished the ... sector managed a flat closing. Major US indices were also ... ended the day at 5,860.63, slightly down by 0.09%; the ... 20,775.60; and the S&P 500 closed at 2,362.82, down 0.11%. ...
(Date:2/23/2017)... 2017  Spheryx, Inc. will present two ... PittCon 2017 Conference and Exposition at McCormick ... largest annual premier conference and exposition on ... of industry, academic and government communities encompassing ... safety, environmental, bioterrorism and other emerging markets.  ...
Breaking Medicine Technology: