Navigation Links
Sickle Cell Disease Tied to Cognitive Difficulties
Date:5/11/2010

Lowered blood oxygen levels may be to blame, researchers say

TUESDAY, May 11 (HealthDay News) -- Adults with sickle cell anemia are at increased risk for neurocognitive problems, which can affect their ability to cope with daily tasks such as work, managing their finances, taking medications, use of community resources, and socializing, a new study finds.

The research included 149 patients with sickle cell anemia (SCA), ages 19 to 55, and a control group of 47 healthy people. Both groups underwent MRI brain scans and tests of neuropsychological function.

Compared to the control group, the SCA patients had statistically significant lower average nonverbal function scores, and lower average scores for measures of processing speed, working memory, global cognitive function (which includes learning, memory and attention processes), and most measures of executive function (which includes the ability to control behavior, anticipate outcomes, adapt to change and make appropriate decisions).

The MRI scans revealed no brain structure differences between the sickle cell anemia patients and the controls. The neurocognitive problems in SCA patients appear to be due to anemia and age, the researchers said.

Adult patients with SCA who do not show symptoms of reasoning and thinking deficits are still at risk for problems in those areas, because their anemia may be causing cognitive impairment as a result of deficient oxygen in the blood that is undetectable by standard neuroimaging studies, according to Dr. Elliott P. Vichinsky, of Children's Hospital & Research Center in Oakland, Calif., and colleagues.

"Several practical steps can be taken. First, early identification of patients with difficulties on specific measures of neurocognitive function may allow these patients to enroll in and benefit from cognitive rehabilitation programs. Additionally, longitudinal studies are necessary to understand and evaluate disease progression. These studies can be linked to biological components to improve understanding of neurocognitive function in SCA," the researchers wrote.

The study appears in the May 12 issue of the Journal of the American Medical Association.

More information

The U.S. National Heart, Lung, and Blood Institute has more about sickle cell anemia.



-- Robert Preidt



SOURCE: Journal of the American Medical Association, news release, May 11, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Blood stem-cell transplant regimen reverses sickle cell disease in adults
2. Bone Marrow Transplants May Cure Sickle Cell in Adults
3. Cholesterol-Lowering Drug Shows Promise Against Serious Infections in Sickle Cell Disease
4. Statins Show Promise Against Sickle Cell
5. New approach to sickle-cell disease shows promise in mice
6. Swine Flu Can Batter Kids With Sickle Cell
7. New study finds barriers to pain treatment in children with sickle cell disease
8. Studies Investigate Emerging Trends and Treatment Options for Patients With Sickle Cell Disease
9. Sickle Cell Disease Patients Seek Acute Pain Care Repeatedly
10. Low blood oxygen may lead to heart defects in children with sickle cell disease
11. New research identifies modifiable risk factors for heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer ... they remain in the eye of the beholder, according to experts who offered insights ... American Journal of Managed Care. For the full issue, click here . , ...
(Date:6/26/2016)... California (PRWEB) , ... June 26, 2016 , ... Pixel ... Cut Pro X. , "Film editors can give their videos a whole new perspective ... Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels contains over ...
(Date:6/26/2016)... Charlotte, NC (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind ... able to be personalized through a fitness app. The fitness app plans to fix the ... solutions currently only offer a one size fits all type program , They ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, ... work on several important health care topics including advance care planning, healthcare costs ...
(Date:6/25/2016)... FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial ... Plant City Observer , brings up a new, often overlooked aspect of head lice: the ... closing for fumigation is not a common occurrence, but a necessary one in the event ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Capricor Therapeutics, Inc. ... company focused on the discovery, development and commercialization ... in its ongoing randomized HOPE-Duchenne clinical trial (Halt ... its 24-patient target. Capricor expects the trial to ... 2016, and to report top line data from ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 ... Tomorrow,s Leaders Scholarship is any indication, the future is ... online at www.diabetesscholars.org by the Diabetes Scholars ... in the way of academic and community service excellence. ... program since 2012, and continues to advocate for people ...
(Date:6/23/2016)... 23, 2016 The vast majority of dialysis ... facility.  Treatments are usually 3 times a week, with ... including travel time, equipment preparation and wait time.  This ... grueling for patients who are elderly and frail.  Many ... and rehabilitation centers for some duration of time. ...
Breaking Medicine Technology: