Navigation Links
Sickle Cell Disease Tied to Cognitive Difficulties
Date:5/11/2010

Lowered blood oxygen levels may be to blame, researchers say

TUESDAY, May 11 (HealthDay News) -- Adults with sickle cell anemia are at increased risk for neurocognitive problems, which can affect their ability to cope with daily tasks such as work, managing their finances, taking medications, use of community resources, and socializing, a new study finds.

The research included 149 patients with sickle cell anemia (SCA), ages 19 to 55, and a control group of 47 healthy people. Both groups underwent MRI brain scans and tests of neuropsychological function.

Compared to the control group, the SCA patients had statistically significant lower average nonverbal function scores, and lower average scores for measures of processing speed, working memory, global cognitive function (which includes learning, memory and attention processes), and most measures of executive function (which includes the ability to control behavior, anticipate outcomes, adapt to change and make appropriate decisions).

The MRI scans revealed no brain structure differences between the sickle cell anemia patients and the controls. The neurocognitive problems in SCA patients appear to be due to anemia and age, the researchers said.

Adult patients with SCA who do not show symptoms of reasoning and thinking deficits are still at risk for problems in those areas, because their anemia may be causing cognitive impairment as a result of deficient oxygen in the blood that is undetectable by standard neuroimaging studies, according to Dr. Elliott P. Vichinsky, of Children's Hospital & Research Center in Oakland, Calif., and colleagues.

"Several practical steps can be taken. First, early identification of patients with difficulties on specific measures of neurocognitive function may allow these patients to enroll in and benefit from cognitive rehabilitation programs. Additionally, longitudinal studies are necessary to understand and evaluate disease progression. These studies can be linked to biological components to improve understanding of neurocognitive function in SCA," the researchers wrote.

The study appears in the May 12 issue of the Journal of the American Medical Association.

More information

The U.S. National Heart, Lung, and Blood Institute has more about sickle cell anemia.



-- Robert Preidt



SOURCE: Journal of the American Medical Association, news release, May 11, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Blood stem-cell transplant regimen reverses sickle cell disease in adults
2. Bone Marrow Transplants May Cure Sickle Cell in Adults
3. Cholesterol-Lowering Drug Shows Promise Against Serious Infections in Sickle Cell Disease
4. Statins Show Promise Against Sickle Cell
5. New approach to sickle-cell disease shows promise in mice
6. Swine Flu Can Batter Kids With Sickle Cell
7. New study finds barriers to pain treatment in children with sickle cell disease
8. Studies Investigate Emerging Trends and Treatment Options for Patients With Sickle Cell Disease
9. Sickle Cell Disease Patients Seek Acute Pain Care Repeatedly
10. Low blood oxygen may lead to heart defects in children with sickle cell disease
11. New research identifies modifiable risk factors for heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... ... January 23, 2017 , ... ... in North America for the scientific development, healthcare training and clinical application of ... and its 2017 AAT Member Certification Qualification Courses for Technicians, respectively. , For ...
(Date:1/23/2017)... ... January 23, 2017 , ... "ProRandom is a set of camera tools that allow video editors ... Final Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. , ... text with video footage. ProRandom works by using a virtual camera to create the ...
(Date:1/23/2017)... ... January 23, 2017 , ... “Crossing the Bar”: ... minutes of a woman’s life. “Crossing the Bar” is the creation of published author, ... children. , Charlotte, who credits the inspiration of the book to her sister, ...
(Date:1/22/2017)... MALO, FRANCE (PRWEB) , ... January 22, 2017 , ... ... Indian Ocean, isolated from the rest of the world with ZANZIBAR MILKY CREAM. Inspired ... Phytocéane used key ingredients like Virgin Coconut Oil and moisturizing vegetal coral to create ...
(Date:1/21/2017)... ... 21, 2017 , ... Salveo for life, a company that distributes an effervescent ... United States as part of its presence to expand its market reach. , Using ... the productions of nasty toxins as a result of drinking alcohol, eliminating those toxins ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... SAN DIEGO , 23 janvier 2017  ResMed ... Winter Haven , Floride) ont annoncé aujourd,hui qu,ils se ... les litiges existants entre les parties. BMC et 3B ... de paiements de droits à ResMed, et ResMed effectuera ... à 3B pour clore le litige de Floride entre ...
(Date:1/23/2017)... and PALMA, Spain , January ... S.L., a clinical-stage biopharmaceutical company focused on treatments ... patient has been enrolled in the Phase IIb ... for the treatment of cardiovascular calcification (CVC) in ... Most ESRD patients, in the last stage of ...
(Date:1/23/2017)... 2017 InDex Pharmaceuticals Holding AB (publ) today ... congress of the European Crohn,s and Colitis Organisation (ECCO). The ECCO ... focus on inflammatory bowel disease (IBD). The congress is held in ... ... to again having been selected to present data at the largest ...
Breaking Medicine Technology: