Navigation Links
Sickle Cell Disease Tied to Cognitive Difficulties
Date:5/11/2010

Lowered blood oxygen levels may be to blame, researchers say

TUESDAY, May 11 (HealthDay News) -- Adults with sickle cell anemia are at increased risk for neurocognitive problems, which can affect their ability to cope with daily tasks such as work, managing their finances, taking medications, use of community resources, and socializing, a new study finds.

The research included 149 patients with sickle cell anemia (SCA), ages 19 to 55, and a control group of 47 healthy people. Both groups underwent MRI brain scans and tests of neuropsychological function.

Compared to the control group, the SCA patients had statistically significant lower average nonverbal function scores, and lower average scores for measures of processing speed, working memory, global cognitive function (which includes learning, memory and attention processes), and most measures of executive function (which includes the ability to control behavior, anticipate outcomes, adapt to change and make appropriate decisions).

The MRI scans revealed no brain structure differences between the sickle cell anemia patients and the controls. The neurocognitive problems in SCA patients appear to be due to anemia and age, the researchers said.

Adult patients with SCA who do not show symptoms of reasoning and thinking deficits are still at risk for problems in those areas, because their anemia may be causing cognitive impairment as a result of deficient oxygen in the blood that is undetectable by standard neuroimaging studies, according to Dr. Elliott P. Vichinsky, of Children's Hospital & Research Center in Oakland, Calif., and colleagues.

"Several practical steps can be taken. First, early identification of patients with difficulties on specific measures of neurocognitive function may allow these patients to enroll in and benefit from cognitive rehabilitation programs. Additionally, longitudinal studies are necessary to understand and evaluate disease progression. These studies can be linked to biological components to improve understanding of neurocognitive function in SCA," the researchers wrote.

The study appears in the May 12 issue of the Journal of the American Medical Association.

More information

The U.S. National Heart, Lung, and Blood Institute has more about sickle cell anemia.



-- Robert Preidt



SOURCE: Journal of the American Medical Association, news release, May 11, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Blood stem-cell transplant regimen reverses sickle cell disease in adults
2. Bone Marrow Transplants May Cure Sickle Cell in Adults
3. Cholesterol-Lowering Drug Shows Promise Against Serious Infections in Sickle Cell Disease
4. Statins Show Promise Against Sickle Cell
5. New approach to sickle-cell disease shows promise in mice
6. Swine Flu Can Batter Kids With Sickle Cell
7. New study finds barriers to pain treatment in children with sickle cell disease
8. Studies Investigate Emerging Trends and Treatment Options for Patients With Sickle Cell Disease
9. Sickle Cell Disease Patients Seek Acute Pain Care Repeatedly
10. Low blood oxygen may lead to heart defects in children with sickle cell disease
11. New research identifies modifiable risk factors for heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ProVest Insurance Group, a family ... and Raleigh regions, is organizing an extended charity drive to benefit the family ... abnormality. , After struggling since birth with several health challenges, T.J. was later ...
(Date:10/13/2017)... ... October 13, 2017 , ... The International Association ... standards of excellence for the field of eating disorders, announces the opening of ... 2018 in Orlando, Florida at the Omni Resort at ChampionsGate. , ...
(Date:10/13/2017)... ... , ... Many families have long-term insurance that covers care for a family ... for care if the client has a cognitive impairment diagnosis. , “What this ... often waived, so the benefits from their insurance start immediately,” said Mechell Vieira, owner ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... viewers the lowdown on sciatica in a new episode of "Success Files," which ... current events and innovation and investigates each subject in-depth with passion and integrity. ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and ... apnea using cutting-edge Oventus O2Vent technology. As many as 18 million Americans ... frequent cessation in breathing. Oral appliances can offer significant relief to about 75 ...
Breaking Medicine News(10 mins):
(Date:10/5/2017)... , Oct. 5, 2017  In response to ... Oral and Maxillofacial Surgeons (AAOMS) released prescribing recommendations ... to be used as a first-line therapy to ... Recognizing the value ... White Paper "Opioid Prescribing: Acute and Postoperative Pain ...
(Date:10/4/2017)... 4, 2017 OBP Medical , ... medical devices, today announced regulatory approval from ... (or Agência Nacional de Vigilância Sanitária (ANVISA)) to ... surgical retractor with integrated LED light source and ... and exposure of a tissue pocket or cavity ...
(Date:10/2/2017)... ORLANDO, Fla. , Oct. 2, 2017  AllianceRx ... services company formed by Walgreens and pharmacy benefit manager ... of its new brand, which included the unveiling of ... Fla. , as well as at a few ... introduces the new brand to patients, some of whom ...
Breaking Medicine Technology: