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Shuttle mice to boost disease research
Date:10/29/2010

GALVESTON, Texas When the space shuttle Discovery lifts off on its final flight Nov. 2, its six astronauts will be joined by 16 rodent passengers on a historic mission of their own.

Riding in special self-contained modules that automatically supply them with food and water, the mice will be part of a long-term NASA effort aimed at understanding why spaceflight makes humans more vulnerable to infection by viruses and bacteria.

The agency has studied the phenomenon aboard its space shuttles for more than 25 years, collecting data from laboratory animals and astronauts themselves. The mouse experiment a collaboration between teams at the University of Texas Medical Branch at Galveston and NASA's Ames Research Center in Mountain View, Calif. will be the final immunology investigation planned for the shuttle program.

"Since the Apollo missions, we have had evidence that astronauts have increased susceptibility to infections during flight and immediately post-flight they seem more vulnerable to cold and flu viruses and urinary tract infections, and viruses like Epstein-Barr, which infect most people and then remain dormant, can reactivate under the stress of spaceflight," said Dr. Roberto Garofalo, a professor at UTMB Health and principal investigator for the project. "We want to discover what triggers this increased susceptibility to infection, with the goal both of protecting the astronauts themselves and people with more vulnerable immune systems here on Earth, such as the elderly and young children."

The mice aboard Discovery will be in orbit for 11 days, during which time shuttle astronauts will perform daily checks on their health and well-being. Within two hours of the shuttle's return to Earth, eight of the animals will be infected with respiratory syncytial virus a pathogen that infects almost all human children by age two and ordinarily causes a relatively harmless cold-like upper respiratory disease. In some child
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Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

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