Navigation Links
Should parents share the results of BRCA1/2 genetic testing with their children?
Date:5/14/2009

ORLANDO (May 14, 2009)If you learned that you were at high risk of cancer because you carry the hereditary BRCA1/2 gene mutation, would you tell your children? A recent study at Fox Chase Cancer Center not only considered that question, but also took it to the next level and studied the parent perceptions of the impact of such a decision on children. The study will be presented at the 2009 Annual Meeting of the American Society of Clinical Oncology. BRCA1/2 are hereditary gene mutations that indicate an increased risk of developing breast cancer.

"We know that many people who carry the BRCA1/2 gene mutation share their genetic test results with their children," explained Angela Bradbury, MD, medical oncologist at Fox Chase and lead author on the study. "What we did not know was the impact this communication has on their children."

In order to learn the impact this has on children, researchers evaluated results from 163 parents who had BRCA1/2 testing. Of those, 52 tested positive for BRCA1/2. Just over 100 parents (66 percent) shared their results with at least one of their children, which totaled 323 children who were between the ages of 5 25. The child's age and parent cancer history had a direct correlation to whether or not they shared the results. Not surprising, those without a BRCA1/2 mutation were more likely to communicate test results than parents with a mutation.

Among parents who disclosed their results, few reported negative reactions from their children (9 percent) or that their child did not understand the information (11 percent). Overall, most parents reported that their children handled the information well, although negative reactions were more frequent among certain subgroups (younger children and those of parents with a mutation or a variant of uncertain significance).

"Many parents share genetic test results with their children," said Bradbury. "According to our research, most parents do not perceive their children to have adverse reactions to this information, although children who learn their parent tested positive for the

BRCA1/2 mutation or a variant of uncertain significance may be more susceptible to initial negative reactions. We certainly need to learn more about how children respond to this information."

Further research with parents and children will be done to explore psychosocial and behavioral responses to learning of hereditary risk during childhood and adolescence, and to inform the development of interventions to optimize adaptive responses to early communication of genetic risk.


'/>"/>

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Related medicine news :

1. Umbilical cord clamping should be delayed, says expert
2. Doctors and medical ethicist discuss whether doctors should participate in capital punishment
3. Doctors and Medical Ethicist Discuss Whether Doctors Should Participate in Capital Punishment
4. When Should Children Wash Their Hands?
5. Judge Rules That Florida Disease Management Program Serving 8,000 HIV/AIDS Patients Should Be Re-bid, Says AIDS Healthcare Foundation
6. Smaller breast reduction surgeries provide health benefits and should be reimbursed
7. GP targets on heart disease should be simpler and based more on treatment and prevention
8. Pro-Consumer Drug Safety Reforms Agreed to in Final FDA Bill; Should End Drug Industry Gaming of Safety System
9. Parents Shouldnt Forget Scoliosis Checks as School Starts
10. New treatment effective for patients with shoulder pain
11. Union Corruption Watchdog Criticizes GM/UAW Deal on Health Care; Says Congress Should Hold Hearings on Lousy Deal for Retirees
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... Birmingham, Lake Orion, Clarkston, Michigan (PRWEB) , ... ... ... their direction with respect to fertility once they have been diagnosed with endometriosis. ... for tolerable intercourse but they also require a comprehensive approach that can help ...
(Date:6/25/2016)... Aliso Viejo, California (PRWEB) , ... June 25, 2016 , ... ... preset to fit their specific project," said Christina Austin - CEO of Pixel Film ... all fully customizable and all within Final Cut Pro X . Simply select ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... On Friday, ... presented a Bronze Wellness at Work award to iHire in recognition of their exemplary ... part of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas ... , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Capricor ... ), a biotechnology company focused on the discovery, ... that patient enrollment in its ongoing randomized HOPE-Duchenne ... exceeded 50% of its 24-patient target. Capricor expects ... third quarter of 2016, and to report top ...
(Date:6/23/2016)... 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in ... America . ... ... ... ...
(Date:6/23/2016)... FRANKLIN, Tenn. , June 23, 2016 ... for automating, integrating and transforming the patient ... launch of several innovative new products and ... depth of its revenue cycle offerings. These ... establish more efficient workflows, remain compliant in ...
Breaking Medicine Technology: