Navigation Links
Should Cystic Fibrosis Patients Get So Many Antibiotics?
Date:3/26/2012

MONDAY, March 26 (HealthDay News) -- Antibiotics can prolong cystic fibrosis patients' lives, but the drugs also help treatment-resistant bacteria thrive in their lungs, a new, small study suggests.

The findings from the 10-year investigation suggest, but do not prove, that the current standard of aggressive antibiotic treatment for cystic fibrosis patients may not always be the best approach.

It's common to use antibiotics to control infection in cystic fibrosis patients' lungs, but maintaining a more diverse range of bacteria in the lungs may help some patients stay healthy longer, according to study senior author Dr. John LiPuma, a research professor of pediatrics and communicable diseases at the University of Michigan Medical School in Ann Arbor.

"The conventional wisdom has been that as patients with cystic fibrosis age and become sicker, as their lung disease progresses, more and more bacteria move in," he said in a university news release. "But our study -- which was the first to examine the bacterial communities in cystic fibrosis patients' lungs over a long period of time -- indicates that's not what happens."

Aggressive use of antibiotics actually lowers the diversity of lung bacteria, resulting in infections that are increasingly difficult to treat. A more diverse community of lung bacteria may help keep the most dangerous strains in check, the researchers noted.

"What we normally do is essentially carpet bombing with antibiotics," explained LiPuma. "However, what we found is that over time this ultimately helps treatment-resistant bacteria by getting rid of their competition."

He said the findings may be a first step toward developing new treatment methods, such as more focused use of antibiotics or even giving cystic fibrosis patients beneficial bacteria.

The study was published March 26 in the Proceedings of the National Academy of Sciences.

Cystic fibrosis is a chronic disease in which the body produces thick, sticky mucus that clogs the lungs. The accumulation of the mucus leaves people prone to serious, hard-to-treat and recurrent infections. Eventually, the repeated infections destroy the lungs.

In the study, researchers examined the bacteria from six patients collected over eight to nine years. Half of the patients had a relatively stable type of the disease and the others had the more typical, faster-progressing form. The investigators conducted DNA analysis on bacteria in 126 sputum samples.

Over time, the researchers found that bacterial diversity declined, yet the overall level of bacteria remained fairly constant. The study authors explained that this means a small number of organisms multiply to take the place of those that have been killed off by antibiotics.

More information

The U.S. National Heart, Lung, and Blood Institute has more about cystic fibrosis.

-- Robert Preidt

SOURCE: University of Michigan, news release, March 26, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Girl Softball Players Suffering More Shoulder Injuries
2. Anthem Blue Crosss Announcement That It Will Temporarily Suspend a 39% Health Insurance Rate Increase Should Not Deter Immediate Legislative Action
3. NIH Stem Cell Guidelines Should Be Modified, UCSF Team Reports
4. Rate Regulation for Health Insurance: Obama Administration Should Look to CAs Model Law Which Has Saved Drivers $62 Billion Since 1988
5. Virtually Everyone Should Get a Flu Shot: CDC
6. HIV drug that protects a fetus should be avoided for one year after childbirth, researchers say
7. California Dental Hygienists Say National Children's Dental Health Month Should Be a Yearlong Effort
8. Six "Common Sense" Points Not Included In The Health Care Discussion? Should They Be?
9. Six "Common Sense" Points Not Included In The Health Care Discussion? Should They Be?
10. Young Men and Elderly Women at Biggest Risk for Shoulder Dislocations
11. Shoulder Dislocations a Sports Hazard
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Should Cystic Fibrosis Patients Get So Many Antibiotics? 
(Date:5/5/2016)... ... May 05, 2016 , ... TLC Laser Eye Centers announced today that it ... center will now be called “Gordon Schanzlin New Vision Institute, a TLC Laser Eye ... full-service facility to ensure that patients continue to receive the highest quality of care. ...
(Date:5/5/2016)... ... May 05, 2016 , ... LELO has discovered many people are ... reach out via email, social media and on the Volonté blog seeking advice about ... I masturbate ‘normal’ or ‘correct’?” , While some methods are more common than others, ...
(Date:5/5/2016)... Collins, CO (PRWEB) , ... May 05, 2016 ... ... announced the commencement of a master charity program created to assist the people ... 60 days, working closely with nonprofit organizations and community leaders. Their hope is ...
(Date:5/5/2016)... Houston, TX (PRWEB) , ... May 05, 2016 , ... ... 2015 AIA/AAH Healthcare Design Awards, presented by the American Institute of Architects and the ... and designed by the renowned Perkins+Will and Harrell Architects, opened to patients in October ...
(Date:5/5/2016)... ARIZ. (PRWEB) , ... May 05, 2016 , ... ... president Jennifer Drago presented a talk highlighting the organization’s successful Care Transitions ... in Chicago. , The talk was titled “Minimizing Costs in the Post-Acute Environment ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... with watching a film or TV show in high definition, you may not be familiar ... Ampronix  is a renowned authorized reseller of the medical industry,s top brands as well as ... ... ... Although initially ...
(Date:5/3/2016)... DUBLIN , May 3, 2016 ... to pay $55 million to a woman who says ... State court awarded Gloria Ristesund $5 million ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ... of accusations against the company. In February, the same ...
(Date:5/3/2016)... JERUSALEM , May 3, 2016 ... (TASE: INTP), a clinical-stage biopharmaceutical company, today announced the ... Clinical and Regulatory Affairs. "Ms. Strauss-Levy has ... affairs, and has established an outstanding track record, having ... development and regulatory approval processes in the ...
Breaking Medicine Technology: