Navigation Links
Shortage of Drug for Children's Cancer May Have Upped Relapse Rates
Date:12/27/2012

By Serena Gordon
HealthDay Reporter

WEDNESDAY, Dec. 26 (HealthDay News) -- When a national shortage of a cancer drug that had helped treat children with Hodgkin's lymphoma for decades forced doctors to find a substitute, they thought they had settled on a drug that would work just as well for these young cancer patients.

But a new analysis suggests they were mistaken.

Mechlorethamine, also known as nitrogen mustard, had been part of a common chemotherapy regimen for Hodgkin's since the 1960s, but experts believed the drug cyclophosphamide would perform equally well. The statistics in the analysis tell another story, however, with two-year remission rates dropping from 88 percent to 75 percent after the switch was made.

"We thought this would be an easy substitution. Cyclophosphamide has been used forever for Hodgkin's lymphoma," said analysis co-author Dr. Monica Metzger, an associate member of the department of oncology at St. Jude Children's Research Hospital in Memphis, Tenn. "We thought the equivalent dose would work just as well, but it doesn't work the same in this chemotherapy regimen. More patients relapsed."

"There are many treatments that work very well. Both mechlorethamine and cyclophosphamide are efficacious, but once you begin a regimen of medications, you have to follow the whole regimen," Metzger said. "It's like a recipe. Like any other recipe, it calls for certain ingredients, and if you make a substitution, you get different results."

The original chemotherapy regimen for Hodgkin's lymphoma, dubbed MOPP, included mechlorethamine, vincristine, procarbazine and prednisone. This combination of drugs was effective, but it also was linked to secondary leukemia and infertility.

Since then, other chemotherapy combinations have been developed to help lessen the side effects. In an effort to further improve outcomes for those with Hodgkin's lymphoma, a newer regimen called Stanford
'/>"/>

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Drug shortage linked to greater risk of relapse in young Hodgkin lymphoma patients
2. Fentanyl Injection Shortages Reported: Severe Adverse Events as AttorneyOne Informs
3. Study Foresees Shortage of Primary-Care Doctors
4. Nurse practitioners: The right prescription to ease doctor shortage
5. $3.4 million HHS grant to help UIC address shortage of Latino health providers
6. Canada needs national approach to protect against drug shortages
7. Brain power shortage
8. AFARs MSTAR program addresses shortage of geriatric medicine physicians
9. US Drug Watchdog Now Urges Loved Ones Of A Diabetic Who Died From Bladder Cancer Who Had Used The Diabetes Drug Called Actos To Call The Johnson Law Group Immediately
10. Dr. Gary McClain of JustGotDiagnosed.com Addresses Prostate Cancer Support Group
11. US cancer screening rates decline over the last 10 years, finds new study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Shortage of Drug for Children's Cancer May Have Upped Relapse Rates 
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... with PureWellness to Provide Online Wellness Platform to All Employees ... ... 29, 2008 -- PureWellness, Inc, a leading provider of ... agreement with Children,s Healthcare of Atlanta, one of the nation,s ...
... pain-free, CHICAGO, July 29 They danced to ... with Jane Fonda and made,jogging their national pastime., ... aren,t,ready to slow down, even if their bodies are. ... than previous generations to seek care when,arthritis develops in ...
... of Wisconsin researchers in Milwaukee have reported that ... a genetic risk factor for Alzheimer,s disease have ... symptoms may appear. , Functional MRI brain ... APOE-4 gene demonstrated significantly reduced functional brain connectivity ...
... with 360 Health & Safety Violations, SALINAS, Calif., ... Center and Windsor Ridge Care Center will,hold a joint ... resident safety. In 2006, both of these homes made ... will be held,simultaneously at eight Bay Area nursing homes ...
... previously thought, researchers say , , MONDAY, July 28 (HealthDay ... of mild cognitive impairment in the elderly population is ... rate of new mild cognitive impairment cases, in this ... Ronald C. Petersen said in a news release. "If ...
... breathing will become even bigger problem, AHA warns , , ... be conducted to determine the exact link between sleep ... the American Heart Association and the American College of ... Circulation . , "There have been a number ...
Cached Medicine News:Health News:Nationally Recognized Pediatric Healthcare System Chooses PureWellness for Employee Wellness Program 2Health News:Nationally Recognized Pediatric Healthcare System Chooses PureWellness for Employee Wellness Program 3Health News:Boomers Not Backing Down From Foot and Ankle Arthritis 2Health News:Boomers Not Backing Down From Foot and Ankle Arthritis 3Health News:Caregivers at 8 Bay Area Nursing Homes Protest Unsafe Resident Conditions in Salinas 2Health News:Rates of Mild Cognitive Impairment Higher Than Expected 2Health News:Rates of Mild Cognitive Impairment Higher Than Expected 3Health News:Experts Urge Research on Sleep Apnea-Heart Disease Link 2
(Date:12/17/2014)... Dec. 17, 2014  ImmunoCellular Therapeutics, Ltd. ("ImmunoCellular") ... and Trademark Office (USPTO) has issued a key ... cell-based immunotherapeutic vaccine targeting six tumor antigens that ... US Patent No. 8,871,211, which issued October 28, ... administering a dendritic cell composition comprising peptide epitopes ...
(Date:12/17/2014)... MARLBOROUGH, Mass. , Dec. 17, 2014 /PRNewswire/ ... a biotechnology company focused on discovering, developing and ... using RNA-targeted technologies, today announced completion of enrollment in ... results from the 3-month observations confirmed the 1-month ... year:  Logo - http://photos.prnewswire.com/prnh/20130917/NE80755LOGO ...
(Date:12/17/2014)... 2014 PCCA received the Autism Hope ... ) program seal for best practices in meeting ... medical practices, materials and goods that meet strict ... Children affected by autism often have unique physical ... ingredients found in food and medicine – for ...
Breaking Medicine Technology:ImmunoCellular Therapeutics Announces Issuance of Key Patent For ICT-107 Cancer Vaccine 2RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 2RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 3RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 4RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 5Parents Of Children With Autism Spectrum Disorder Have New Options When Administering Medications 2Parents Of Children With Autism Spectrum Disorder Have New Options When Administering Medications 3
... Texas, June 28, 2011 Pharmacy Choice and ... local businesses and pharmacists across the nation and ... care – applauds the Texas Legislature for the ... critical amendments that provide necessary protections for Texans ...
... RESTON, Va., June 28, 2011 The Mirixa ... Stores (CACDS) are pleased to announce that MirixaPro(SM), ... standardized, pharmacy-based patient care service delivery, will be ... 10-year licensing agreement enabling CACDS to use a ...
Cached Medicine Technology:Pharmacy Choice and Access Now Coalition Applauds Passage of Senate Bill 7 During Texas Legislature's Special Session 2Mirixa and CACDS Sign Agreement for Clinical Service Delivery Platform 2Mirixa and CACDS Sign Agreement for Clinical Service Delivery Platform 3
The ELISA test is used for detection and semi quantitation of igG antibodies to proteinase 3(PR3) in human sera, as an aid to the diagnosis is of Wegener's granulomatosis....
... MRSA is a differential medium designed ... of MRSA. Selective agents are incorporated ... most strains of S. epidermidis and ... substrate resulting in mauve colonies, thus ...
The Linvatec 3mm and 5mm Universal Light Guides are autoclavable. They offer flexibility, superior light transmission, and universal fittings in a lightweight package....
... is equipped with a 180 watt Xenon short arc ... energy transfer from the lamp to the light guide, ... is equivalent to higher watt bulbs. A new IR ... bulb reduces the amount of heat generated from the ...
Medicine Products: