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Short-term smoking cessation reverses endothelial damage
Date:8/31/2013

said: "This indicates that endothelial function had improved after 8 weeks of smoking cessation but serotonin levels remained at dangerously high levels."

An analysis of all 21 subjects who tried to stop smoking showed that serotonin levels were positively correlated with serum levels of cotinine (152140 ng/ml, r=0.45, P<0.05) and inversely with PAT ratio (endothelial function: 0.250.10, r=-0.45, P<0.05). Dr Dohi said: "These results show that smoking cessation may have a beneficial effect on serotonin levels, but this effect is too small to normalise serotonin levels within 8 weeks. It will take a long time to see a significant effect on serotonin levels after smoking cessation."

Dr Dohi concluded: "Short term smoking cessation only partially improved the undesirable alterations caused by smoking. After 8 weeks of no smoking endothelial function improved but plasma serotonin remained high, suggesting that patients are still at increased risk of cardiovascular disease. Further studies are needed to see if longer term smoking cessation can completely reverse the damage caused by smoking."


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Contact: Celine Colas
press@escardio.org
44-773-005-7146
European Society of Cardiology
Source:Eurekalert

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