Navigation Links
Short-term smoking cessation reverses endothelial damage
Date:8/31/2013

Dr Dohi said: "Smokers are twice as likely to have a heart attack as people who have never smoked. Quitting smoking is the most important thing people can do to reduce their risk of cardiovascular disease. But until now, studies have not examined whether the increased risk caused by smoking is completely reversed after smoking cessation."

The current study investigated how the vascular system is altered by smoking and whether the changes can be normalised by smoking cessation. The researchers focused on the effects of smoking and smoking cessation on arterial endothelial function and circulating serotonin concentration.

Both endothelial dysfunction and serotonin contribute to the development of atherosclerosis. Serotonin released from platelets induces platelet aggregation, which initiates blood coagulation and contractions in arteries especially those with damaged endothelium.

Smoke from cigarettes contains toxic molecules including nicotine, carbon monoxide and hydrogen cyanide which may cause and promote atherosclerosis via endothelial dysfunction and increased activity of blood coagulation.

The study included 27 apparently healthy male smokers aged 408 years and 21 age-adjusted non-smokers (407 years). Endothelial function was assessed by flow mediated dilation and peripheral arterial tonometry (PAT). Both methods assess endothelial function as the ability to dilate arteries through the release of endothelium-derived relaxing factors.

Dr Dohi said: "As expected, smoking damaged arterial endothelial function and increased plasma serotonin levels."

Only 21 subjects agreed to stop smoking for 8 weeks. Smoking cessation was confirmed in 11 out of the 21 subjects by measuring serum levels of cotinine, the principal metabolite of nicotine. Smokers who completely attained smoking cessation had a significantly increased PAT ratio (P<0.05) but serotonin levels were not significantly changed (see figure). Dr Dohi said: "This indicates that endothelial function had improved after 8 weeks of smoking cessation but serotonin levels remained at dangerously high levels."

An analysis of all 21 subjects who tried to stop smoking showed that serotonin levels were positively correlated with serum levels of cotinine (152140 ng/ml, r=0.45, P<0.05) and inversely with PAT ratio (endothelial function: 0.250.10, r=-0.45, P<0.05). Dr Dohi said: "These results show that smoking cessation may have a beneficial effect on serotonin levels, but this effect is too small to normalise serotonin levels within 8 weeks. It will take a long time to see a significant effect on serotonin levels after smoking cessation."

Dr Dohi concluded: "Short term smoking cessation only partially improved the undesirable alterations caused by smoking. After 8 weeks of no smoking endothelial function improved but plasma serotonin remained high, suggesting that patients are still at increased risk of cardiovascular disease. Further studies are needed to see if longer term smoking cessation can completely reverse the damage caused by smoking."


'/>"/>

Contact: Celine Colas
press@escardio.org
44-773-005-7146
European Society of Cardiology
Source:Eurekalert

Related medicine news :

1. Swallowing exercises linked with short-term improvement among patients with head and neck cancer
2. Atrial fibrillation: Flec-SL trial proves efficacy of short-term antiarrhythmic drug treatment
3. Case Western Reserve researchers create short-term memories in-vitro
4. Short-Term, Early HRT May Cut Womens Alzheimers Risk: Study
5. Therapy with bone marrow-derived stem cells does not improve short-term recovery after heart attack
6. Short-Term Exercise Might Boost Young Peoples Self-Control
7. Health info exchange: Short-term growth, but long-term concerns
8. Trinity Management Announces Just a Few Apartment Units Remain Available for Short-term America’s Cup Rentals
9. Anti-tobacco TV ads help adults stop smoking, study finds
10. Exercise helps smokers to quit smoking, to remain smoke-free and to reduce the risk of death
11. Small neural focus groups predict anti-smoking ad success
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... Texas (PRWEB) , ... October 13, 2017 , ... Yisrayl ... this week that explains one of the most popular and least understood books in ... like cryptic and puzzling descriptions that have baffled scholars for centuries. Many have tossed ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian history of ... Brink” is the creation of published author, William Nowers. Captain Nowers and his ... veteran, he spent thirty years in the Navy. Following his career as a ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has developed ... consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every formula has ... highest standard. , These products are also: Gluten Free, Non-GMO, Vegan, Soy ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... that we intend to develop to enable prevention of a major side effect ... hearing loss, especially in pediatric patients. For cisplatin, hearing loss is FDA listed ...
(Date:10/12/2017)... ... ... On Saturday, October 21, the Health & Wellness Center at Florida Hospital ... for the American Heart Association Heart Walk. Teams of up to 10 people can ... their treadmills moving for 5 hours. Treadmills will start at 7:00 p.m. on Saturday, ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  Hill-Rom Holdings, Inc. ... Aspen Surgical facility in Las Piedras, Puerto ... scalpels and blades. ... that the facility sustained minor structural damage, temporary loss ... Maria. Repairs have been completed, manufacturing operations have resumed, ...
(Date:10/7/2017)... Oct. 6, 2017   Provista, a proven ... $100 billion in purchasing power, today announced a new ... The Newsroom is the online home for ... infographics, expert bios, news releases, slideshows and events. ... a wealth of resources at their fingertips, viewers can ...
(Date:10/4/2017)... 2017  According to the Centers for Disease Control and Prevention (CDC), ... PhysicianOne Urgent Care is helping communities across Massachusetts , ... by offering no-cost* flu shots through the end of the month. ... insurance regulations. ... get a flu shot is by the end of October, according to ...
Breaking Medicine Technology: