Navigation Links
Short-term smoking cessation reverses endothelial damage
Date:8/31/2013

Dr Dohi said: "Smokers are twice as likely to have a heart attack as people who have never smoked. Quitting smoking is the most important thing people can do to reduce their risk of cardiovascular disease. But until now, studies have not examined whether the increased risk caused by smoking is completely reversed after smoking cessation."

The current study investigated how the vascular system is altered by smoking and whether the changes can be normalised by smoking cessation. The researchers focused on the effects of smoking and smoking cessation on arterial endothelial function and circulating serotonin concentration.

Both endothelial dysfunction and serotonin contribute to the development of atherosclerosis. Serotonin released from platelets induces platelet aggregation, which initiates blood coagulation and contractions in arteries especially those with damaged endothelium.

Smoke from cigarettes contains toxic molecules including nicotine, carbon monoxide and hydrogen cyanide which may cause and promote atherosclerosis via endothelial dysfunction and increased activity of blood coagulation.

The study included 27 apparently healthy male smokers aged 408 years and 21 age-adjusted non-smokers (407 years). Endothelial function was assessed by flow mediated dilation and peripheral arterial tonometry (PAT). Both methods assess endothelial function as the ability to dilate arteries through the release of endothelium-derived relaxing factors.

Dr Dohi said: "As expected, smoking damaged arterial endothelial function and increased plasma serotonin levels."

Only 21 subjects agreed to stop smoking for 8 weeks. Smoking cessation was confirmed in 11 out of the 21 subjects by measuring serum levels of cotinine, the principal metabolite of nicotine. Smokers who completely attained smoking cessation had a significantly increased PAT ratio (P<0.05) but serotonin levels were not significantly changed (see figure). Dr Dohi said: "This indicates that endothelial function had improved after 8 weeks of smoking cessation but serotonin levels remained at dangerously high levels."

An analysis of all 21 subjects who tried to stop smoking showed that serotonin levels were positively correlated with serum levels of cotinine (152140 ng/ml, r=0.45, P<0.05) and inversely with PAT ratio (endothelial function: 0.250.10, r=-0.45, P<0.05). Dr Dohi said: "These results show that smoking cessation may have a beneficial effect on serotonin levels, but this effect is too small to normalise serotonin levels within 8 weeks. It will take a long time to see a significant effect on serotonin levels after smoking cessation."

Dr Dohi concluded: "Short term smoking cessation only partially improved the undesirable alterations caused by smoking. After 8 weeks of no smoking endothelial function improved but plasma serotonin remained high, suggesting that patients are still at increased risk of cardiovascular disease. Further studies are needed to see if longer term smoking cessation can completely reverse the damage caused by smoking."


'/>"/>

Contact: Celine Colas
press@escardio.org
44-773-005-7146
European Society of Cardiology
Source:Eurekalert

Related medicine news :

1. Swallowing exercises linked with short-term improvement among patients with head and neck cancer
2. Atrial fibrillation: Flec-SL trial proves efficacy of short-term antiarrhythmic drug treatment
3. Case Western Reserve researchers create short-term memories in-vitro
4. Short-Term, Early HRT May Cut Womens Alzheimers Risk: Study
5. Therapy with bone marrow-derived stem cells does not improve short-term recovery after heart attack
6. Short-Term Exercise Might Boost Young Peoples Self-Control
7. Health info exchange: Short-term growth, but long-term concerns
8. Trinity Management Announces Just a Few Apartment Units Remain Available for Short-term America’s Cup Rentals
9. Anti-tobacco TV ads help adults stop smoking, study finds
10. Exercise helps smokers to quit smoking, to remain smoke-free and to reduce the risk of death
11. Small neural focus groups predict anti-smoking ad success
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... ... 30, 2017 , ... The Aresty Institute of Executive Education ... to address the increasingly complex educational needs of today's global executives. Corporate ... corporate finance and will increase their ability to confidently take action in ways ...
(Date:3/30/2017)... ... 30, 2017 , ... Nutrition Education for the Public (NEP), ... join nonprofit Seafood Nutrition Partnership (SNP) in presenting “Eating Heart Healthy: Exploring Issues ... educators and students inform consumers about the health benefits of eating a seafood-rich ...
(Date:3/29/2017)... ... , ... During the last week of March, Chad Kawa, MD of Revere ... the local community. , Colon cancer is the second leading cause of cancer ... it is small, confined and easier to treat. If you are 50 or older, ...
(Date:3/29/2017)... , ... March 29, 2017 , ... ... women’s professional squash, announced it has enlisted New York City-based sports and entertainment ... will develop and procure sponsorship opportunities for the Professional Squash Association (PSA), which ...
(Date:3/29/2017)... Baltimore, MD (PRWEB) , ... March 30, 2017 , ... ... , Charm City Run has announced that Mercy Medical Center will serve as the ... in the Mid-Atlantic region. On Sunday, June 25, 2017, thousands of women will walk ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... Research and Markets has announced the ... 2025" report to their offering. ... The global orthopedic navigation ... 2025. Increasing geriatric population prone to orthopedic diseases is a ... over the forecast period. Osteoarthritis and osteoporosis are most common ...
(Date:3/29/2017)... , March 29, 2017  Experts in the ... monitoring devices like  Soberlink Systems  as a model ... paper, published in early 2017, concluded that remote ... in managing patient recovery." The findings ... of Addiction Medicine, detail a range of variables ...
(Date:3/29/2017)... , March 29, 2017  Glenmark Pharmaceuticals, a ... GSP 301, an investigational fixed-dose combination of mometasone ... administered twice-daily as a nasal spray being studied ... results are from a recently completed Phase 3 ... 301 combination therapy versus mometasone, olopatadine or placebo. ...
Breaking Medicine Technology: