Navigation Links
Short nanotubes target pancreatic cancer
Date:6/5/2014

Short, customized carbon nanotubes have the potential to deliver drugs to pancreatic cancer cells and destroy them from within, according to researchers at Rice University and the University of Texas MD Anderson Cancer Center.

Pristine nanotubes produced through a new process developed at Rice can be modified to carry drugs to tumors through gaps in blood-vessel walls that larger particles cannot fit through.

The nanotubes may then target and infiltrate the cancerous cells' nuclei, where the drugs can be released through sonication that is, by shaking them.

The research led by Rice chemist Andrew Barron was reported in the Royal Society of Chemistry's Journal of Materials Chemistry B.

Most pancreatic cancer patients die within a year of diagnosis and have a five-year survival rate of 6 percent, partially because there is no method for early detection, according to the American Cancer Society. Tumors are often inoperable and pancreatic cancer cells are also difficult to reach with chemotherapy, said co-author Jason Fleming, a professor of surgical oncology at MD Anderson.

"These findings are encouraging because they offer a potential delivery solution for pancreatic cancer patients whose tumors resist standard chemotherapy," Fleming said. "There are molecular and biological barriers to efficient delivery of chemotherapy to pancreatic cancer tumors, and these nanotubes might be able to make some of those irrelevant."

Rice scientists made nanotubes pure enough to modify for the purpose and small enough to squeeze through the body's defenses, Barron said. The researchers knew from previous work that nanotubes could be modified a process called functionalization to carry chemotherapy agents and release them at a controlled rate through sonication.

"This time, we were trying to work out how long the tubes should be and the extent of functionalization to maximize uptake by the cells," Barron said.

Several discoveries were key, he said. First, Rice graduate student, alumnus and co-author Alvin Orbaek purified the carbon nanotubes of iron catalysts necessary to their growth by flushing them with chlorine. "Leftover iron particles damage the tubes through oxidation," Barron said. "That makes subsequent use difficult."

The next step was to cut the nanotubes down to size. Very long nanotubes are floppy and hard to deal with, Barron said. Enrico Andreoli, a postdoctoral research associate in Barron's group and lead author of the paper, used a thermal process to chop them to an average length of 50 nanometers. (A human hair is about 100,000 nanometers wide.)

"Instead of ending up with a fluffy nanotube powder, we get something that looks like a hockey puck," Barron said. "It's not dense it looks like a spongy puck but you can cut it with a razor blade. You can weigh it and do accurate chemistry with it."

Barron's lab added polyethyleneimine (PEI) to the nanotube surfaces. In lab tests, the modified tubes were easily dispersed in liquid and able to pass through barriers into live cancer cells to infiltrate the nuclei. A small-molecule variant of PEI proved to be less toxic to cells than larger versions, Barron said.

"This research shows that the particles are small enough to get inside cells where you like them to be and that they may have an increased killing advantage but that's still unknown," Fleming said.

Fleming, whose work focuses on improving drug delivery for pancreatic cancer, cautioned that more research is required. "The next step will be to test this approach in mice that have allografts taken from human tumors," he said. "The architecture of these tumors will more closely resemble that of human pancreatic cancer."


'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert  

Related medicine news :

1. Scripps Florida scientists unravel the molecular secret of short, intense workouts
2. Shorter TB treatment regimens will reduce cost for patients and their families
3. Addressing the physician shortage: Recommendations for medical education reform
4. Women repeatedly short-changed in case of premature ejaculation
5. Women with unintended pregnancies take the shortest maternity leaves
6. Loss of Y chromosome can explain shorter life expectancy and higher cancer risk for men
7. Food shortages could be most critical world issue by mid-century
8. Short circuit in molecular switch intensifies pain
9. Introducing a New Sand Wedge that Is Perfect for Taking Strokes off the Short Game, Courtesy of Black Magic’s Innovative Golf Wedge
10. Black Magic’s Advanced Engineering With Golf Equipment for the Short Game Offers a Top of the Line Gap Wedge That Can Have You Shooting Lower Scores in No Time
11. New Collection Of Short Wedding Dresses Available At FannyBrides.com
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Short nanotubes target pancreatic cancer
(Date:8/18/2017)... (PRWEB) , ... August 18, ... ... d/b/a Quick International, LLC (“Quick”), a highly specialized asset-light logistics provider of ... entered into a definitive agreement to purchase Unitrans International Corporation, a division ...
(Date:8/18/2017)... NY (PRWEB) , ... August 18, 2017 , ... ... of “Vision & Hearing” campaign, advocating for active, healthy lifestyles and highlighting the ... available for individuals with hearing impairments and shares the latest innovations in hearing ...
(Date:8/18/2017)... McLean, VA (PRWEB) , ... August 18, 2017 ... ... offers asset protection services and financial consultations to communities throughout the greater DC ... Semper K9 with the goal of rescuing local animals and training them to ...
(Date:8/18/2017)... ... August 18, 2017 , ... MLM Insurance Group, a Miami ... southern Florida, is working to support the Take Stock In Children Foundation during ... families. , The Take Stock In Children Foundation (TSC) offers guidance and assistance ...
(Date:8/18/2017)... ... August 18, 2017 , ... The Golseth Agency, a Texas based insurance management ... spearheading a regional charity campaign organized to provide support to Christina Upchurch and her ... year, Christina and her children returned from out of town to find her husband ...
Breaking Medicine News(10 mins):
(Date:7/27/2017)... Services, Inc. (NYSE: WST ) today announced ... financial guidance for the full-year 2017. ... Reported net sales of $397.6 million, a record high, ... constant currency (organic) grew by 3.9%. ... in the prior-year quarter. Second-quarter 2017 adjusted diluted EPS ...
(Date:7/26/2017)... SINGAPORE , July 27, 2017  Radium Medical Aesthetics, a ... LASEMD, designed to delay aging by effectively addressing several skin conditions ... the skin to become rougher and more fragile. The skin becomes ... the unavoidable exposure to the harmful UV rays from the sun ... hyperpigmentation. ...
(Date:7/26/2017)... , July 26, 2017 The Galien ... Prix Galien USA Award Nominees. Counted ... Prix Galien Award recognizes outstanding biomedical and technology product achievement ... To qualify, each candidate must be U.S. Food ... five years and demonstrate tremendous potential to impact human health. ...
Breaking Medicine Technology: