Navigation Links
Short nanotubes target pancreatic cancer
Date:6/5/2014

Short, customized carbon nanotubes have the potential to deliver drugs to pancreatic cancer cells and destroy them from within, according to researchers at Rice University and the University of Texas MD Anderson Cancer Center.

Pristine nanotubes produced through a new process developed at Rice can be modified to carry drugs to tumors through gaps in blood-vessel walls that larger particles cannot fit through.

The nanotubes may then target and infiltrate the cancerous cells' nuclei, where the drugs can be released through sonication that is, by shaking them.

The research led by Rice chemist Andrew Barron was reported in the Royal Society of Chemistry's Journal of Materials Chemistry B.

Most pancreatic cancer patients die within a year of diagnosis and have a five-year survival rate of 6 percent, partially because there is no method for early detection, according to the American Cancer Society. Tumors are often inoperable and pancreatic cancer cells are also difficult to reach with chemotherapy, said co-author Jason Fleming, a professor of surgical oncology at MD Anderson.

"These findings are encouraging because they offer a potential delivery solution for pancreatic cancer patients whose tumors resist standard chemotherapy," Fleming said. "There are molecular and biological barriers to efficient delivery of chemotherapy to pancreatic cancer tumors, and these nanotubes might be able to make some of those irrelevant."

Rice scientists made nanotubes pure enough to modify for the purpose and small enough to squeeze through the body's defenses, Barron said. The researchers knew from previous work that nanotubes could be modified a process called functionalization to carry chemotherapy agents and release them at a controlled rate through sonication.

"This time, we were trying to work out how long the tubes should be and the extent of functionalization to maximize uptake by the cells," Barron said.

Several discoveries were key, he said. First, Rice graduate student, alumnus and co-author Alvin Orbaek purified the carbon nanotubes of iron catalysts necessary to their growth by flushing them with chlorine. "Leftover iron particles damage the tubes through oxidation," Barron said. "That makes subsequent use difficult."

The next step was to cut the nanotubes down to size. Very long nanotubes are floppy and hard to deal with, Barron said. Enrico Andreoli, a postdoctoral research associate in Barron's group and lead author of the paper, used a thermal process to chop them to an average length of 50 nanometers. (A human hair is about 100,000 nanometers wide.)

"Instead of ending up with a fluffy nanotube powder, we get something that looks like a hockey puck," Barron said. "It's not dense it looks like a spongy puck but you can cut it with a razor blade. You can weigh it and do accurate chemistry with it."

Barron's lab added polyethyleneimine (PEI) to the nanotube surfaces. In lab tests, the modified tubes were easily dispersed in liquid and able to pass through barriers into live cancer cells to infiltrate the nuclei. A small-molecule variant of PEI proved to be less toxic to cells than larger versions, Barron said.

"This research shows that the particles are small enough to get inside cells where you like them to be and that they may have an increased killing advantage but that's still unknown," Fleming said.

Fleming, whose work focuses on improving drug delivery for pancreatic cancer, cautioned that more research is required. "The next step will be to test this approach in mice that have allografts taken from human tumors," he said. "The architecture of these tumors will more closely resemble that of human pancreatic cancer."


'/>"/>

Contact: David Ruth
david@rice.edu
713-348-6327
Rice University
Source:Eurekalert  

Related medicine news :

1. Scripps Florida scientists unravel the molecular secret of short, intense workouts
2. Shorter TB treatment regimens will reduce cost for patients and their families
3. Addressing the physician shortage: Recommendations for medical education reform
4. Women repeatedly short-changed in case of premature ejaculation
5. Women with unintended pregnancies take the shortest maternity leaves
6. Loss of Y chromosome can explain shorter life expectancy and higher cancer risk for men
7. Food shortages could be most critical world issue by mid-century
8. Short circuit in molecular switch intensifies pain
9. Introducing a New Sand Wedge that Is Perfect for Taking Strokes off the Short Game, Courtesy of Black Magic’s Innovative Golf Wedge
10. Black Magic’s Advanced Engineering With Golf Equipment for the Short Game Offers a Top of the Line Gap Wedge That Can Have You Shooting Lower Scores in No Time
11. New Collection Of Short Wedding Dresses Available At FannyBrides.com
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Short nanotubes target pancreatic cancer
(Date:1/16/2017)... MA (PRWEB) , ... January 17, 2017 , ... ... season, Au Bon Pain, an internationally recognized leader in the fast-casual category, announces ... items such as the Good Egg Breakfast Sandwich, Turkey Mash-Up Sandwich, Cranberry Crunch ...
(Date:1/16/2017)... (PRWEB) , ... January 16, 2017 , ... California Southern ... Beazley has served on CalSouthern’s Board of Trustees and as a core faculty member, ... he has been a professor of psychology at Pepperdine University, where he earned his ...
(Date:1/16/2017)... Elk Grove Village, IL (PRWEB) , ... January ... ... protection and personal audio products, will demonstrate their groundbreaking GunSport•PRO® and EB15•LE® electronic ... Expo and Convention Center in Las Vegas, Booth #2809. The SHOT Show is ...
(Date:1/16/2017)... ... , ... Anybody who may be looking for a substance abuse rehabilitation program ... Recovery, a holistic treatment center for addiction located in Marne, MI. This video, which ... patients and staff that visited the 2016 Recovery Palooza support event in nearby Grand ...
(Date:1/16/2017)... ... 16, 2017 , ... As New York’s fastest growing ophthalmic ... to their medical staff, according to eye surgeon, Jeffrey Martin, MD, FACS, Chief ... division of SightMD. Dr. Giamos will practice primarily out of SightMD’s Riverhead, Southampton, ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... According to a new market research report "Neural Network Software Market by Type ... Region - Global Forecast to 2021" published by MarketsandMarkets, the market to expand ... a Compound Annual Growth Rate (CAGR) of 33.2%. ... ... ...
(Date:1/17/2017)...  Market Research Future published a Half Cooked Research Report on ... reach USD 33.6 million during the period 2016 to 2022 from ... ... has been examined as a swiftly growing market and expected to ... endoscopy device in various regions.  The increasing growth in endoscopy procedures ...
(Date:1/17/2017)... Calif. and KANSAS CITY, ... Children,s Hospitals Neonatal Consortium (CHNC) has selected Velos ... their visionary data management and multicenter initiatives. ... organization comprised of 32 Neonatal Intensive Care Units ... America . The consortium provides a benchmark ...
Breaking Medicine Technology: