Navigation Links
Short-Term Air Pollution Exposure May Damage DNA
Date:5/17/2009

Gene reprogramming can occur in just 3 days time

SUNDAY, May 17 (HealthDay News) -- Breathing polluted air for even a short period of time can cause some genes to undergo reprogramming, which may affect a person's risk of developing cancer and other diseases, say Italian researchers.

Comparisons of blood DNA samples from healthy workers who were exposed to high levels of airborne particulates at a foundry near Milan revealed that after only three days of exposure, changes occurred in four genes that have been linked to tumor suppression, according to research presented Sunday at the International Conference of the American Thoracic Society, in San Diego.

This finding indicates "that environmental factors need little time to cause gene reprogramming, which is potentially associated with disease outcomes," investigator Dr. Andrea Baccarelli, assistant professor of applied biotechnology at the University of Milan, said in a news release issued by the conference's sponsor.

"As several of the effects of particulate matter in foundries are similar to those found after exposure to ambient air pollution, our results open new hypotheses about how air pollutants modify human health," Baccarelli said.

The changes in the foundry workers' genes may have been caused by DNA methylation, a chemical transformation process that has been linked to gene reprogramming and has been found in the blood and tissue samples of lung cancer patients, Baccarelli noted.

"The changes in DNA methylation we observed are reversible, and some of them are currently being used as targets of cancer drugs," said the researcher, who added that it might be possible to design early interventions that could program that gene back to normal and mitigate the increased health risks of air pollutants.

"We need to evaluate how the changes in gene reprogramming we observed are related to cancer risk," Baccarelli said.

More information

The U.S. National Heart, Lung, and Blood Institute has more about lung disease.



-- Kevin McKeever



SOURCE: American Thoracic Society, news release, May 17, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Chem Rx Corporation Enters Short-Term Forbearance Agreements With Lenders
2. Decoding short-term memory with fMRI
3. Assessing the real risk of heart disease in young people with low short-term risks
4. New data show patients using avonex reported less sick leave and short-term disability costs
5. Short-term use of antipsychotics in older adults with dementia linked to serious adverse events
6. FDA Approves NEXIUM(R) for the Treatment of Short-Term GERD in Children 1 to 11 Years Old
7. Journal Sleep: A short-term dose of zolpidem is an effective treatment for insomnia
8. The Westaim Corporation update on status of short-term investments
9. Short-term hemofiltration is cost-effective for severe acute pancreatitis
10. Physiotherapy has short-term benefits for patients after knee surgery
11. Air Pollution Exposure May Slow Fetal Growth
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Short-Term Air Pollution Exposure May Damage DNA
(Date:6/25/2016)... ... 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the ... to iHire in recognition of their exemplary accomplishments in worksite health promotion. , The ... Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort ... holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain ... Disease (SCD) is a disorder of the red blood cells, which can cause episodes ...
(Date:6/24/2016)... Francisco, CA (PRWEB) , ... June 24, 2016 ... ... CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive ... self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented ... in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor the ... Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With this award, ...
(Date:6/24/2016)... ... June 24, 2016 , ... National recruitment firm Slone Partners ... with extensive sequencing and genomics experience, as Vice President of North American Capital Sales ... be responsible for leading the sales team in the commercialization of the HTG EdgeSeq ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 Roche ... received 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) ... severe sepsis or septic shock. With this clearance, Roche ... provide a fully integrated solution for sepsis risk assessment ... associated with bacterial infection and PCT levels in blood ...
(Date:6/23/2016)... WAYNE, Pa. , June 23, 2016 ... provider, will launch its next generation clinical outcomes platform, Bracket ... DIA Meeting held on June 26 – 30, 2016 in ... 6.0, the first electronic Clinical Outcome Assessment product of its ... DIA Booth #715. Bracket eCOA 6.0 is a ...
(Date:6/23/2016)... Revolutionary technology includes multi-speaker listening ... industry leaders in advanced audiology and hearing aid technology, ... ™, the world,s first internet connected hearing aid that ...      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) , ... ,world firsts,: , TwinLink™ - the first ...
Breaking Medicine Technology: