Navigation Links
Short-Term Air Pollution Exposure May Damage DNA
Date:5/17/2009

Gene reprogramming can occur in just 3 days time

SUNDAY, May 17 (HealthDay News) -- Breathing polluted air for even a short period of time can cause some genes to undergo reprogramming, which may affect a person's risk of developing cancer and other diseases, say Italian researchers.

Comparisons of blood DNA samples from healthy workers who were exposed to high levels of airborne particulates at a foundry near Milan revealed that after only three days of exposure, changes occurred in four genes that have been linked to tumor suppression, according to research presented Sunday at the International Conference of the American Thoracic Society, in San Diego.

This finding indicates "that environmental factors need little time to cause gene reprogramming, which is potentially associated with disease outcomes," investigator Dr. Andrea Baccarelli, assistant professor of applied biotechnology at the University of Milan, said in a news release issued by the conference's sponsor.

"As several of the effects of particulate matter in foundries are similar to those found after exposure to ambient air pollution, our results open new hypotheses about how air pollutants modify human health," Baccarelli said.

The changes in the foundry workers' genes may have been caused by DNA methylation, a chemical transformation process that has been linked to gene reprogramming and has been found in the blood and tissue samples of lung cancer patients, Baccarelli noted.

"The changes in DNA methylation we observed are reversible, and some of them are currently being used as targets of cancer drugs," said the researcher, who added that it might be possible to design early interventions that could program that gene back to normal and mitigate the increased health risks of air pollutants.

"We need to evaluate how the changes in gene reprogramming we observed are related to cancer risk," Baccarelli said.

More information

The U.S. National Heart, Lung, and Blood Institute has more about lung disease.



-- Kevin McKeever



SOURCE: American Thoracic Society, news release, May 17, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Chem Rx Corporation Enters Short-Term Forbearance Agreements With Lenders
2. Decoding short-term memory with fMRI
3. Assessing the real risk of heart disease in young people with low short-term risks
4. New data show patients using avonex reported less sick leave and short-term disability costs
5. Short-term use of antipsychotics in older adults with dementia linked to serious adverse events
6. FDA Approves NEXIUM(R) for the Treatment of Short-Term GERD in Children 1 to 11 Years Old
7. Journal Sleep: A short-term dose of zolpidem is an effective treatment for insomnia
8. The Westaim Corporation update on status of short-term investments
9. Short-term hemofiltration is cost-effective for severe acute pancreatitis
10. Physiotherapy has short-term benefits for patients after knee surgery
11. Air Pollution Exposure May Slow Fetal Growth
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Short-Term Air Pollution Exposure May Damage DNA
(Date:5/24/2016)... , ... May 24, 2016 , ... How to Write ... Raleigh, NC, http://www.fdanews.com/humanerrordrugdevice , Human error is known to be the major ... human error will ever be totally eliminated, many human performance problems can be prevented. ...
(Date:5/24/2016)... ... (PRWEB) May 24, 2016 -- Grow ... its Advisory Board. Joining the Grow Healthy Advisory Board team ... them embody the mission of our organization and bring talent, expertise ... them as we continue to expand our footprint as the leader ...
(Date:5/24/2016)... ... May 24, 2016 , ... Backed by ... logger for each job, ensuring the best suited solution to meet regulatory requirements. ... loggers at their lab in Istanbul. , Metroloji Okulu specializes in MadgeTech’s line ...
(Date:5/24/2016)... ... May 24, 2016 , ... The Radiosurgery Society (RSS), ... radiosurgery, is recognizing five medical residents and students for their outstanding contributions to ... The awards will be presented at the 2016 SRS/SBRT Scientific Meeting taking place ...
(Date:5/24/2016)... OR (PRWEB) , ... May 24, 2016 , ... ... welcomed Peggy Kinst, a wellness specialist for forty years and a trainer for ... the Sharon Kleyne Hour Radio Talk Show on May 16, 2016. , Formerly ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... 2016 Celsion Corporation (NASDAQ: ... provided an update on its ongoing OVATION study, ... GEN-1, the Company,s DNA-based immunotherapy, with the standard ... with advanced ovarian cancer who will undergo neoadjuvant ... an IL-12 DNA plasmid vector formulated as a ...
(Date:5/24/2016)... 24, 2016 Los innovadores ... del mundo, introduce catéteres para la intervención de ... una compañía global especializada en el suministro de ... su cartera incluyendo productos para tratar la enfermedad ... PTA son los dispositivos de primera entrada de ...
(Date:5/24/2016)... 24, 2016 Dutch surgeons have launched a ... the world and treat patients on a global scale. Medical professionals ... Asia and the US have already signed ... and networking in a totally secure environment. Education  ... zone working together with a surgeon at Harvard to treat a ...
Breaking Medicine Technology: