Navigation Links
Short RNA strand helps exposed skin cells protect body from bacteria, dehydration and even cancer
Date:3/2/2008

ithelial tissues, to be exact -- and only in this skin type's outer layers. What's more, this expression pattern is identical to that found in humans, zebrafish, chickens and the like -- in other words, vertebrates that evolved more than 400 million years apart.

"If it has been expressed in this very specific tissue for a long time and across several species, it means that it probably plays an important role there," says Yi. To find out its function, Yi, in one set of experiments, used a genetic technique to precociously express microRNA in the inner layer of the skin, where stem cells proliferate at a fast clip. In a second set of experiments, he blocked microRNA-203 from functioning in the outer layer using an antagomir, a molecule that binds directly to microRNA-203 and shuts down its ability to carry out its function.

In the first set, he found that the stem cells proliferated significantly less than they did when microRNA-203 wasn't expressed, and, as a result, the mice formed very thin skin -- hardly a protective layer at all. The stem cells, the researchers saw, lost their ability to proliferate not because microRNA-203 killed them off but because it suppressed the activity of a molecule called p63, whose job is to keep cells, primarily stem cells, proliferating. In the second set of experiments, Yi found that the cells in the outer layer proliferated significantly more than they did when microRNA-203 was expressed. The reason: because microRNA-203 wasn't available to shut down p63's busy work.

"We found that microRNA-203 acts to stop the translation of the p63 protein," says Fuchs. "The result is a swift transition from proliferating stem cells within the innermost layer of the epidermis and terminally differentiating cells as they exit this layer and move outward to the skin surface."

The findings have intriguing implications for cancer, since p63 is found in excess in cancer cells. "As a next step, we are going to exa
'/>"/>

Contact: Thania Benios
tbenios@rockefeller.edu
212-327-7146
Rockefeller University
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. U.S. Teens Fall Short on Vaccine Coverage
2. Nicotine in Breast Milk Shortens Babys Naptime
3. Chicagoland Psoriasis Event Saturday Will Celebrate First National Short Sleeve Day
4. Psoriasis Cure Now Rolls Out First National Short Sleeve Day Saturday
5. DC Psoriasis Event Saturday Will Celebrate First National Short Sleeve Day
6. Salt Lake City Psoriasis Event Saturday Will Celebrate First National Short Sleeve Day
7. San Francisco Psoriasis Event Tonight Will Celebrate First National Short Sleeve Day
8. FDA Approves LEVAQUIN(R) Short-Course Therapy for Treatment of Complicated Urinary Tract Infections and Acute Pyelonephritis
9. Hospitals See Infection Rates More Than Halved, Patient Stays Shortened by 27 Percent in New Study Announced by I-Flow
10. Critical blood shortages eased by new technology
11. Physiotherapy has short-term benefits for patients after knee surgery
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Short RNA strand helps exposed skin cells protect body from bacteria, dehydration and even cancer
(Date:10/2/2014)... HealthDay Reporter WEDNESDAY, Oct. 1, ... the stops to rescue surgical patients in crisis are ... such heroism is questionable, a new study suggests. ... saving elderly patients with life-threatening complications after major surgery, ... senior author Dr. Amir Ghaferi. He is assistant professor ...
(Date:10/1/2014)... has shown that more than 80 per cent of ... The study found that medicines called ,JAK inhibitors, halted ... that is present in more than 80 per cent ... or are in clinical trials, for diseases including rheumatoid ... cancer is the second-most common cancer in Australia with ...
(Date:10/1/2014)... BOSTON (October 1, 2014) Despite a policy ... with developmental disabilities, this vulnerable population continues to ... of The Journal of the American Dental ... Medicine and Tufts University School of Dental Medicine ... factors influencing at-home oral care provided by caregivers ...
(Date:10/1/2014)... Hills, CA (PRWEB) October 01, 2014 ... internationally-franchised Fit Body Boot Camp fitness boot camps, he’s ... selling personal training , with sold out business summits, ... stint as marketing consultant to a recent Spike TV ... Keuilian says that now is the time for personal ...
(Date:10/1/2014)... October 01, 2014 Farmington Company ... a redefined mission and visual identity helping brokers, ... partnering with them to create greater benefit communication ... that focuses on empowering customers to better leverage ... The crown jewel of the rebrand is the ...
Breaking Medicine News(10 mins):Health News:'High-Intensity' Hospitals Save More Elderly After Surgery: Study 2Health News:'High-Intensity' Hospitals Save More Elderly After Surgery: Study 3Health News:Eighty percent of bowel cancers halted with existing medicines 2Health News:To improve oral health of adults with developmental disabilities, support caregivers 2Health News:To improve oral health of adults with developmental disabilities, support caregivers 3Health News:Bedros Keuilian Shares Tips on Selling Personal Training for the Holidays 2Health News:Bedros Keuilian Shares Tips on Selling Personal Training for the Holidays 3Health News:Farmington Company Launches Rebrand and New Positioning 2
... Feb. 15 that a 70 % minimum requirement in the ... for admission to medical// and dental colleges in the open ... % of the weightage for admission in medical and dental ... common entrance test (CET), the government said it would be ...
... and sound health info Kerala and Goa have lifted the ... revealed by Minister for Medical Education and Animal Husbandry V.S. ... that this indicates that the situation is under control. ... make policies Chief Minister H.D. Kumaraswamy said the Government has ...
... charge contraceptives have a VAT of 17.5% on them. This ... in the ensuing budget.,Gordon Brown is due to present the ... Street chemist Superdrug which said that it was confident of ... said the move followed a successful 10-month campaign. ...
... Researchers from Texas A&M University said that poorly maintained ... breeding grounds for potentially lethal bacterial strains. They tested ... some kind of microbial growth.// ,Various Bacterial ... of the samples, while 81% had fungi and 34% ...
... Indian mind trainer and motivator has been helping South Africans ... subconscious mind. ,Jeetendra Adhia's workshops in various cities seek to ... the mind which he says lies between the conscious state ... never utilised more than 10 percent of their mind power," ...
... Researchers have developed a molecular map and other similar ... found in the Asian population//. ,'The inroads ... more effectively,' said Professor Soo Khee Chee, director of ... led by the NCC included experts from the University ...
Cached Medicine News:
(Date:9/30/2014)... This report analyzes the worldwide markets for Enteral Feeding Devices ... Pumps, Nasogastric Tubes, and Others. The report provides ... , Europe , Asia-Pacific ... of World. Annual estimates and forecasts are provided for the ... provided for these markets. The report profiles 38 ...
(Date:9/30/2014)... BEDFORD, Mass. , Sept. 30, 2014  Hologic, ... Stephen MacMillan , Hologic,s President and Chief Executive ... Bell Ceremony on October 1, the first day of ... will discuss the Company,s campaign focused on the important ... system approved by the FDA as clinically superior to ...
(Date:9/30/2014)... ROCKVILLE, Md. , Sept. 30, 2014 /PRNewswire/ ... natural way to modernize medicine, announced today the ... line of nutraceuticals developed to address men and ... staying healthy and vibrant into old age while ... line includes three condition-specific, whole-food and herb-based formulas, ...
Breaking Medicine Technology:Global Enteral Feeding Devices Industry 2Global Enteral Feeding Devices Industry 3Global Enteral Feeding Devices Industry 4Global Enteral Feeding Devices Industry 5Global Enteral Feeding Devices Industry 6Global Enteral Feeding Devices Industry 7Global Enteral Feeding Devices Industry 8Global Enteral Feeding Devices Industry 9Global Enteral Feeding Devices Industry 10Global Enteral Feeding Devices Industry 11Global Enteral Feeding Devices Industry 12Global Enteral Feeding Devices Industry 13Global Enteral Feeding Devices Industry 14Global Enteral Feeding Devices Industry 15Global Enteral Feeding Devices Industry 16Global Enteral Feeding Devices Industry 17Global Enteral Feeding Devices Industry 18Global Enteral Feeding Devices Industry 19Hologic to Kick Off National Breast Cancer Awareness Month at the October 1 NASDAQ Stock Market Opening Bell Ceremony 2Hologic to Kick Off National Breast Cancer Awareness Month at the October 1 NASDAQ Stock Market Opening Bell Ceremony 3
... Therapy Services Holdings, Inc. ("Radiation Therapy Services" or the "Company") ... Wells Fargo Securities 2011 Healthcare Conference on Wednesday, June 22, ... held at the Intercontinental Hotel in Boston, MA. ... available by visiting the Events section of the Company,s Web ...
... ERT ), announced today that Keith ... present at the 2011 Wells Fargo Securities Healthcare ... in Boston. Interested parties may access ... at  http://www.ert.com . The webcast may also be ...
Cached Medicine Technology:ERT to Present at the 2011 Wells Fargo Securities Healthcare Conference on June 23, 2011 2
Suture Cutters, Straight...
Suture scissor...
Threaded cannula for use with Suretac® II, sterile packs, box of 10....
The Small Oval Cannula System is designed to be the smallest oval cannula system currently available, and is utilized with the Caspari Suture Punch System. Disposable seals are available with this sy...
Medicine Products: