Navigation Links
Shire investigational nonstimulant INTUNIV showed significant efficacy in reducing ADHD symptoms
Date:5/7/2008

WASHINGTON, May 7 -- Shire plc(LSE: SHP, Nasdaq: SHPGY), the global specialty biopharmaceutical company, presented today at a major scientific meeting findings from analyses of pivotal trial results of INTUNIV, a selective alpha-2A-agonist. This compound is an investigational once-daily medication, which is being evaluated for the treatment of the symptoms of Attention Deficit Hyperactivity Disorder (ADHD). The data demonstrated that INTUNIV showed significant efficacy in reducing ADHD symptoms for patients taking the medication when compared to patients taking placebo at all measured time points up to 24 hours postdose.

The U.S. Food and Drug Administration (FDA) issued an approvable letter on June 20, 2007, regarding INTUNIV. Shire is conducting additional clinical work which is designed to enhance the label. Upon approval, INTUNIV will be the first selective alpha-2A receptor agonist indicated for the treatment of ADHD that may provide an important treatment option for patients and physicians.

Summary of Analyses

The pooled analysis evaluated results from these patients on a weight adjusted mg/kg basis from two similarly designed, randomized, double-blind, forced-dose titration, multicenter phase III trials. The primary efficacy measure for both studies was change in the ADHD Rating Scale (ADHD-RS-IV) total score from baseline to endpoint. All patient groups treated with INTUNIV showed significantly greater improvement in ADHD-RS-IV total score from baseline to endpoint than the placebo group (P < .001). The ADHD-RS-IV is a standardized, validated test for assessing symptoms of ADHD and for assessing their response to treatment.

The analysis also studied duration of effect using the Conners' Parent Rating Scale-Revised Short Form (CPRS-R), which is a comprehensive scale that used observer and self-report ratings to help assess ADHD and evaluate be
'/>"/>

Contact: MIchelle Park
212-601-8248
Porter Novelli
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Anthem Blue Cross and Blue Shield in New Hampshire Announces Unique Enhancement to its ePrescribing Program
2. Shire to present ADHD treatments scientific data at American Psychiatric Assoc. Meeting
3. AUDIO from Medialink and Shire: What It Means to be an Adult With ADHD
4. Shire Launches Patient Education Forums on Better Managing the Challenges of Ulcerative Colitis
5. VIDEO from Medialink and Shire plc: Rare Diseases Must Be Top of the Health Agenda
6. New Hampshire AIDS Group Calls on Huckabee to Disavow His 1992 Statement
7. Shire to Present New Scientific Data on its ADHD Treatments at a Major Psychiatric Meeting
8. New Hampshire: 1st in the Nation Primary State Takes a Stand on E-Prescribing
9. Families Invited to Celebrate Shire Day at Boston Childrens Museum
10. URAC CEO Testifies Before New Hampshire Legislators Regarding New URAC Standards for Pharmacy Benefit Management
11. Exciting New Plan from John Edwards on AIDS; Plan is Bold and Achievable, say New Hampshire Activists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... OH (PRWEB) December 22, 2014 Explorys, ... three additions to its leadership team: Greg Yarrington as ... of Engineering, and Patrick Wells as Vice President of ... to add 80 new jobs in 2015 to support ... expansion of its platform-as-a-service offerings, and growth of its ...
(Date:12/22/2014)... CA (PRWEB) December 22, 2014 ... now offering consultations for sleep apnea. Drowsy drivers are ... than drivers who are well-rested, and some experts believe ... the roads as intoxicated drivers. Unfortunately, millions of Americans ... the American Academy of Sleep Medicine, about 18 million ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 Christmas is days ... has a fast and easy solution that will please: the ... can be purchased from from $25 up to $350," says ... 100% customer satisfaction and a wide array of skin care ... fees and no expiration dates. , Gift delivery past ...
(Date:12/22/2014)... Washington, DC (PRWEB) December 22, 2014 ... Nursing Leadership Conference, next month in San ... strategies to address dynamics that often stand in ... authority, and competition. , This premier faculty ... Center for Transformational Leadership, whose mission is to ...
(Date:12/21/2014)... (PRWEB) December 22, 2014 BellasDress.com offers ... more for women. Today, it announces its BellasDress ... products at its online store. , BellasDress is a ... benefits to its fans through a series of promotions. ... for every customer. , “We are proud of ...
Breaking Medicine News(10 mins):Health News:Explorys Continues to Experience Rapid Growth, Adds Three Healthcare IT Executives to Its Leadership Team 2Health News:Explorys Continues to Experience Rapid Growth, Adds Three Healthcare IT Executives to Its Leadership Team 3Health News:Pasadena Dentist, Dr. Marine Martirosyan, Now Offers Consultations for Sleep Apnea 2Health News:2015 NLN Leadership Conference February 5-7 San Antonio 2Health News:2015 NLN Leadership Conference February 5-7 San Antonio 3Health News:BellasDress.com Announces its BellasDress Christmas Sale 2
... development by a team of researchers at the University of ... medical procedures. , The system works by using a Web-based ... children from the procedures that cause the pain. The distractions ... watching a video, talking, or playing a game. , The ...
... is proud to announce,that President and CEO Humberto ... Jury President for North America. Jury members for ... their,achievements in the business, non-profit and academic fields, ... The awards, an annual distinction supporting innovative woman-led,business ...
... to Brooke Army Medical Center, RESTON, Va., ... ), an information technology and network solutions (IT),company, ... competitive task order under,the US Army,s HRsolutions Indefinite ... and Support to provide,services to Brooke Army Medical ...
... Illinois at Chicago has been named one of 10 ... consumers and clinicians make critical treatment decisions about therapeutic ... of the Agency for Healthcare Research and Quality,s Center ... It will design and test systems to optimize drug ...
... Oct. 16 (HealthDay News) -- A new gene associated with ... Dmp1 gene may help improve understanding of what ... , The Wake Forest University School of Medicine researchers analyzed ... the Dmp1 gene -- which normally works to ...
... 16 Starpharma,Holdings Ltd (ASX: SPL, Pink Sheets: ... SSL International plc (LSE: SSL), owner of Durex(R), ... which a commercial licence will be negotiated,sets out ... coating.,Undisclosed fees are payable to Starpharma under the ...
Cached Medicine News:Health News:UI researchers seek to ease children's pain during medical procedures 2Health News:UI researchers seek to ease children's pain during medical procedures 3Health News:Galderma Associates Itself to Cartier's Women's Initiative Awards to Recognize Female Entrepreneurs From Around the Globe 2Health News:Galderma Associates Itself to Cartier's Women's Initiative Awards to Recognize Female Entrepreneurs From Around the Globe 3Health News:SI International Awarded $4 Million Army HRsolutions Task Order 2Health News:SI International Awarded $4 Million Army HRsolutions Task Order 3Health News:New UIC center to study drug choices, safety 2Health News:Researchers ID New Gene Linked to Lung Cancer 2Health News:Starpharma and Durex Sign Co-Development Agreement for VivaGel(R)-Coated Condoms 2
(Date:12/19/2014)... and CARDIFF-BY-THE-SEA, Calif. , Dec. ... SRNE ;  Sorrento), an oncology company developing ... Conkwest, Inc., a privately-held immuno-oncology company developing proprietary ... cell-line based therapy, announced today that the companies ... develop next generation CAR-TNK™ (pronounced as "Car-Tank") immunotherapies ...
(Date:12/19/2014)... , Dec. 18, 2014  Decision Resources Group finds ... United States will increase to a value ... primarily driven by expansion in the large direct energy ... will be increasingly adopted due to the advantages they ... Other key findings from Decision Resources Group,s coverage of ...
(Date:12/19/2014)... Kan. , Dec. 18, 2014   ... ), a biopharmaceutical company focused on the licensing, ... animals, today announced positive results from its pivotal ... drug for treating pain in dogs with osteoarthritis. ... in pain assessment scores that were statistically significant ...
Breaking Medicine Technology:Sorrento and Conkwest Announce Exclusive Global Collaboration 2Sorrento and Conkwest Announce Exclusive Global Collaboration 3Sorrento and Conkwest Announce Exclusive Global Collaboration 4Sorrento and Conkwest Announce Exclusive Global Collaboration 5U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 2U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 2Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 4Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 5
Concave inner surface to conform to the globe. Used in conjunction with the E5381 600 Circling Band (40 style). Indications: Wide scleral bed. Outside diameter 30.2 mm....
...
...
...
Medicine Products: