Navigation Links
Shining a light on disease -- tracking light-emitting bacteria during infection
Date:9/8/2009

By attaching light-emitting genes to infectious bacteria in an experimental system, researchers at University College, Cork, Ireland, have been able to track where in the body the bacteria go giving an insight into the path of the infection process leading to the development of more targeted treatments.

At the Society for General Microbiology's meeting at Heriot-Watt University, Edinburgh, Dr Cormac Gahan described how his research team had manipulated the infectious food-borne pathogen Listeria monocytogenes to emit enough light for an ultra-sensitive camera system to detect these bacteria during infection of living mice in real time. This non-invasive procedure allowed individual animals to be analysed over the course of a lengthy infection and therefore reduced the numbers of animals required for infection studies.

This bioluminescence technology showed the researchers that Listeria bacteria migrated to the kidneys and gall bladders of normal mice during infection. In mice with cancer, the bacterium migrated very efficiently to the tumour tissue. The team went on to investigate the possibility that Listeria could be used to kill tumour cells by delivering DNA containing the codes for proteins to kill the tumour.

"Bioluminescence imaging in bacterial infections has great potential to provide information on the cause of infectious diseases," said Dr Gahan, "The technology allows the researcher to pinpoint exactly where in the body the bacteria reside during infection. We have also demonstrated that the technology can indicate which bacterial genes are switched on during infection. The use of this approach will underpin the development and testing of new vaccine and DNA-delivery vectors for protection against bacterial diseases."


'/>"/>

Contact: Dianne Stilwell
diannestilwell@me.com
07-957-200-214
Society for General Microbiology
Source:Eurekalert

Page: 1

Related medicine news :

1. International Aid Named as a MinistryWatch.com Shining Light Christian Ministry
2. Shining light on sciences dark data: New venture ensures a fuller scientific record
3. China-Biotics, Inc. Expands Retail Network to 60 Shining Retail Centers
4. Shining a Light on Sunscreen: Sun Protection Misconceptions Unveiled by Dr. Jeffrey Dover and CVS/pharmacy
5. Partnership Applauds President for Shining Light on True Cost Driver in Health Care - Calls on CBO to Join the Effort
6. Five Healthcare Organizations Honored as Shining Stars by The Beryl Institute
7. Stanford study highlights cost-effective method of lowering heart disease risks
8. Study shines more light on benefit of vitamin D in fighting cancer
9. Bacteria See the Light
10. Quantum light beams good for fast technology
11. Free will takes flight: how our brains respond to an approaching menace
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2017)... (PRWEB) , ... April 25, 2017 , ... ... a breakthrough topical cream that’s the first in a new class of photodynamic ... the overall appearance of skin, visibly reduce outward signs of aging, and minimize ...
(Date:4/25/2017)... ... April 25, 2017 , ... As President Trump challenges ... for how his administration could impact the employee benefits industry. James Slotnick, AVP, ... most likely to make it through Congress. His discussion will focus on the ...
(Date:4/25/2017)... ... April 25, 2017 , ... ... rely on contracted partners to help with process innovation in drug formulation and ... formulation experience along with state-of-the-art analytical equipment in support of their development and ...
(Date:4/25/2017)... ... April 25, 2017 , ... Somnoware, a ... its patient care management module. Using this new feature, sleep physicians can now ... initiated on continuous positive airway pressure (CPAP), oral, or other forms of sleep ...
(Date:4/24/2017)... ... April 24, 2017 , ... Emmanuel College is introducing ... advance their careers. Beginning in the fall of 2017, Emmanuel’s program will allow registered ... few as 16 months and for as little as $14,528. These changes will enable ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... India , April 19, 2017 ... and Application, Forecast to 2022 report has covered and analysed ... statistics and information on market size, shares and growth factors. ... major drivers, challenges and opportunities in the global market. ... Browse 152 Tables and Figures, ...
(Date:4/19/2017)... Companion animal vaccines ... pets such as canine, avian and feline. ... such as Attenuated Live Vaccines, Conjugate Vaccines, Inactivated ... Recombinant Vaccines. Attenuated live vaccines are derived from ... have been weakend under laboratory conditions. Conjugate vaccines ...
(Date:4/19/2017)... , April 19, 2017  Novartis today ... the National Heart, Lung, and Blood Institute (NHLBI) ... that 58% of patients with treatment-naïve severe aplastic ... when treated with eltrombopag at the initiation of ... The study evaluated three sequential treatment groups, or ...
Breaking Medicine Technology: