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Sharp as a Tack at 90: Here's Why
Date:8/17/2012

By Jenifer Goodwin
HealthDay Reporter

THURSDAY, Aug. 16 (HealthDay News) -- Elderly people who experience no decline in memory have certain brain characteristics that differ from their peers who show more typical age-related memory loss, new research reveals.

Scientists from Northwestern University's Cognitive Neurology and Alzheimer's Disease Center identified 12 people aged 80 and older who did as well or better on memory tests as people who were 20 to 30 years younger. Researchers dubbed them "SuperAgers."

MRI scans showed that the cortex of SuperAgers was thicker than a comparison group of people aged 80 and older. The cortex is the outer layer of the brain involved in memory, attention and other thinking abilities.

A thinning cortex suggests a loss of brain cells, or gray matter, explained senior study author Emily Rogalski, an assistant research professor at Northwestern.

Brain scans also showed that people in their 80s and 90s who exhibited more typical memory declines (though not the marked decline associated with Alzheimer's disease or other thinking impairments, researchers said) had a thinner cortex.

"The SuperAgers looked more like the middle-aged controls, despite being 20 to 30 years older," Rogalski said. "We didn't see any significant atrophy or brain cell loss."

The study is published in the current issue of the Journal of the International Neuropsychological Society.

Some degree of forgetfulness is a common complaint among the elderly, Rogalski said. "These complaints are so widespread that it's come to be thought of as a normal part of aging," she noted.

Many prior studies have shown that brain atrophy and loss of thinking abilities go hand in hand, said Dr. Russell Swerdlow, director of the Alzheimer's Disease Center at the University of Kansas.

This study is unique in that it starts with people with exceptionally good memories for their age, and t
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