Navigation Links
Sharp Rise in Risk With New Breast Cancer Gene, Scientists Say
Date:8/7/2014

elihood she could get cancer," Greenberg said. "I would frame it as a very relevant question for PALB2 carriers."

Doctors also could recommend more aggressive surveillance for breast cancer, such as annual mammograms or MRI breast screening, Tischkowitz said.

About one in every 1,000 women carry the PALB2 mutation, said study co-author William Foulkes, director of the Program in Cancer Genetics at McGill University's Center for Translational Research in Cancer, located in Montreal.

"It's not common, but the risks are significant," Foulkes said. "Particularly for a woman with a strong family history of breast cancer, they may want to find out if they have this mutation."

Genetic tests for breast cancer already include PALB2 in their panel, Foulkes added.

"In the past few years, it's become easier to test for a package of genes at once," he said. "Women who have had a genetic test should go back and check their records. They may have been tested for PALB2 already and not even know it."

The new PALB2 study involved an international team of researchers from 17 centers in eight countries, led by the University of Cambridge. The scientists analyzed data from 362 family members with PALB2 gene mutations from 154 families without BRCA1 or BRCA2 mutations.

Women who carried rare mutations in PALB2 were found to have, on average, a 33 percent chance of developing breast cancer by age 70.

BRCA1, BRCA2 and PALB2 all play an important role in the repair of damaged DNA. "PALB2 interacts with BRCA2, and acts as a kind of a bridge between BRCA1 and BRCA2," Foulkes explained. Mutation of any of the genes impairs the body's ability to fix broken DNA, which can lead to cancer.

In a separate study also published in the same issue of the NEJM, doctors identified another gene called MEN1 that is linked to breast cancer.

Mutations of the MEN1 gene can cause a rare inherited cancer of the endocrine glands called multiple en
'/>"/>

Copyright©2014 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Natalie Sharp's Pure Vitality Rx Upgrade - Partnership With Shangri-La Spa and Website Facelift!
2. Testicular Cancer Up Sharply Among Young Hispanics, Study Finds
3. Can Games, Puzzles Keep Aging Minds Sharp?
4. Sharp decline in maternal and child deaths globally, new data show
5. NIH grantees sharpen understanding of antibodies that may cut risk of HIV infection
6. “Supreme Mind Mastery” Teaches People How To Sharpen Their Brain With Simple Exercises – Vkoolelite
7. Learning new skills keeps an aging mind sharp
8. Sharp rise in opioid drugs prescribed for non-cancer pain, reports study in Medical Care
9. Gaster Sharpley Sheds Light on the Grief Process
10. NFL Hall-of-Famer & CBS Analyst Shannon Sharpe Joins FitnessRx for Men
11. Sharp Rise in ICU Admissions From U.S. Emergency Rooms
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sharp Rise in Risk With New Breast Cancer Gene, Scientists Say 
(Date:5/5/2015)... 05, 2015 There have been numerous ... focused primarily on personal lines (home, auto, etc). Now, ... Insurance (NDOI.com) has created an online vehicle for ... U.S. to present their expertise in all realms of ... is significant and two-fold. , First, the online, searchable ...
(Date:5/4/2015)... (PRWEB) May 05, 2015 ... honors Irene Taylor , Volunteer Executive Director ... a 2015-2016 inductee into its VIP Woman of ... prestigious distinction for leadership in business. NAPW is ... women, boasting more than 700,000 members and over ...
(Date:5/4/2015)... 2015 The National Association of ... as a 2015-2016 inductee into the NAPW VIP Woman ... prestigious distinction for leadership in oral healthcare. NAPW is ... boasting more than 700,000 members and over 200 operating ... this exceptional group of professional women," said NAPW President ...
(Date:5/4/2015)... May 04, 2015 Global Vision, ... proofreading technologies, today announced that it will showcase ... Music City Center, in Nashville Tennessee, May 04 ... world's first true all-in-one we-based packaging inspection suite, ... the security of their brand copy and artwork. ...
(Date:5/4/2015)... (PRWEB) May 04, 2015 The ... Group today launched a new initiative at UC ... next generation of physicians committed to advancing Latino ... Ser Medicos, or Preparing Students to Be Physicians, ... that will provide scholarships, mentorship and internship opportunities, ...
Breaking Medicine News(10 mins):Health News:NDOI Launch Brings Commercial Insurance Online for the First Time 2Health News:NDOI Launch Brings Commercial Insurance Online for the First Time 3Health News:National Association of Professional Women Inducts Irene Taylor into its 2015-2016 VIP Woman of the Year Circle 2Health News:National Association of Professional Women Inducts Elizabeth Moncada, Owner, Moncada Center for Orofacial Pain, into its 2015-2016 VIP Woman of the Year Circle 2Health News:Global Vision to Spotlight Proofware at INFO*FLEX 2015 2Health News:New UC Davis Program Targets Next Generation of Physicians to Advance Latino Health 2Health News:New UC Davis Program Targets Next Generation of Physicians to Advance Latino Health 3Health News:New UC Davis Program Targets Next Generation of Physicians to Advance Latino Health 4Health News:New UC Davis Program Targets Next Generation of Physicians to Advance Latino Health 5
... prices are bouncing back slowly after its steep fall from ... promotional campaigns, free bies and on the house access to ... inching itself back onto people’s plates. ,The farm-gate ... egg from Rs 1.20 while the chicken prices had hit ...
... the plane to the gulf, not so much for greener pastures ... // The demand for rabbit meat has increased following the bird ... for what was a dry gulf palate sans the chicken. ... and this has led to several enquiries flooding the State Animal ...
... poorly-maintained air-conditioning towers.,It is an air borne disease and has ... exposure. // ,Symptoms include headaches, fever, chills and ... north of Melbourne. So far ten victims have been diagnosed ... positive to the airborne disease and was admitted to the ...
... doing their bit to raise awareness about Ovarian Cancer as ... a nice gesture that celebrities are lending their support to ... killer" in medical circles. ,"For too long ovarian ... now shows that, even in the early stages, most women ...
... confirmed that the dreaded bird flu had made an entry into ... cat had died of bird flu. Since then the country has ... Federal Agriculture and Protection of Consumer Minister Horst Seehofer has said ... kept inside homes, while it is compulsory to keep dogs on ...
... gigantic problem but Childhood obesity rates are soaring as well.Studies ... the world by the end of the decade and raise ... by 2010 the number of overweight and obese youngsters in ... ,Over a million children will show signs of high blood ...
Cached Medicine News:
(Date:5/4/2015)... 2015  BioSpecifics Technologies Corp. (NASDAQ: BSTC ), ... marketed as XIAFLEX ® (collagenase clostridium histolyticum or ... EU, will announce its first quarter 2015 financial results ... Monday, May 11, 2015 and will host a conference ... day, Tuesday May 12, 2015.  In ...
(Date:5/4/2015)... May 4, 2015 Microbrush International, a leading ... in dental restorative procedures, today announced the acquisition ... an innovative sectional matrix system used in dental ... about the opportunity to add DentiSmart to our ... Frymark , VP and General Manager of Microbrush. ...
(Date:5/4/2015)... , May 4, 2015   The New ... injection, Kybella, from internationally acclaimed plastic surgeon, Dr. ... and Drug Administration, is proven to reduce fat deposits ... The active ingredient in Kybella, ... gives plastic surgeons the ability to reshape this area ...
Breaking Medicine Technology:BioSpecifics Technologies Corp. to Report First Quarter 2015 Financial Results on Monday, May 11, 2015 2Microbrush International Announces Acquisition of DentiSmart 2Dr. Rod Rohrich Provides Medical Expertise on Kybella 2Dr. Rod Rohrich Provides Medical Expertise on Kybella 3
... Ltd. (Nasdaq: ACAS ) announced today that ... its affiliates, in the debt and equity of portfolio ... on women,s health.   "American Capital is pleased ... it continues to grow its medical device business focused ...
... March 8, 2012 Reportlinker.com announces that a ... catalogue:   ... http://www.reportlinker.com/p0151191/Global-Ophthalmic-Lasers-Industry.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Ophthalmi   The global ... of statistical anecdotes, market briefs, and concise summaries ...
Cached Medicine Technology:American Capital and its Affiliates Invest $20 Million in Portfolio Company Halt Medical 2Global Ophthalmic Lasers Industry 2Global Ophthalmic Lasers Industry 3Global Ophthalmic Lasers Industry 4Global Ophthalmic Lasers Industry 5
... 560 Cryo-Star - a vision becomes ... which offer the users many benefits.,The ... cryostat with retraction that incorporates a ... and knife cooling. This facilitates applications ...
... microtome with automatic fine/trim- feed system, ... precision cross roller bearings. For sectioning ... in biological, botany, and materials science. ... 90 mm can be accommodated. Performance, ...
... is a robust rotary microtome designed ... specimens embedded in paraffin. The microtome's ... feed system ensures premium quality sections ... harder tissues. The RM2235 is available ...
... sliding microtome with low-maintenance cross-roller-bearing guideways ... in routine histopathology laboratories. The SM2000 ... some specific industrial sectioning applications. The ... meet most of today's sliding microtome ...
Medicine Products: