Navigation Links
Shark cartilage shows no benefit as a therapeutic agent for lung cancer
Date:5/26/2010

HOUSTON - In the first scientific study of its kind, shark cartilage extract, AE-941 or Neovastat, has shown no benefit as a therapeutic agent when combined with chemotherapy and radiation for patients with advanced non-small cell lung cancer, according to researchers at The University of Texas MD Anderson Cancer Center.

The study was published in the Journal of the National Cancer Institute; the findings were first presented at the 43rd annual meeting of the American Society of Clinical Oncology.

The absence of blood vessels in cartilage as well as preclinical studies analyzing cartilage extracts have supported the hypothesis that cartilage contains inhibitors of angiogenesis. Also, shark cartilage has long intrigued the public due to the belief that the incidence of cancer in this cartilaginous fish is very rare. Early Phase I and II studies in lung and renal cancers suggested some benefit to patients when AE-941 was given at higher doses, said Charles Lu, M.D. associate professor in MD Anderson's Department of Thoracic Head and Neck Medical Oncology.

"This is the first large Phase III randomized trial of shark cartilage as a cancer agent. A unique and important aspect about this shark cartilage study was that this product, Neovastat, was never sold over-the-counter, unlike other shark cartilage compounds previously studied. The company, Aeterna Zentaris, developed the compound as a pharmaceutical as opposed to a compound sold for profit that is available over the Internet, for example," said Lu, the study's national principal investigator and corresponding author.

The international Phase III study enrolled 379 newly-diagnosed untreated Stage III non-small cell lung cancer patients at 53 sites in the United Sates and in Canada from June 2000 to February 2006. MD Anderson enrolled 60 patients in the trial.

The study was initiated at the request of, and was supported by, the National Cancer Institute (NCI) who sought proposals from pharmaceutical companies regarding their shark cartilage agents.

All study participants received the standard treatment of induction chemotherapy and chemo-radiation. Patients were randomized to receive either shark cartilage or placebo, both in the form of a liquid. Patients drank four ounces of the extract twice daily, and continued on the shark cartilage/placebo as maintenance after completing standard therapy.

Researchers say that the study did not meet its primary endpoint: survival. With a median follow-up of 3.7 years, researchers did not find a statistical difference in survival between patients who received the shark cartilage, 14.4 months, and those who received the placebo, 15.6 months.

"Clearly, these results demonstrate that AE-941 is not an effective therapeutic agent for lung cancer," said Lu. "So, too, these findings have to cast major skepticism on shark cartilage products that are being sold for profit and have no data to support their efficacy as cancer-fighting agent."

Patients who are currently taking shark cartilage should be very cautious in accepting that the therapy will be beneficial, warns Lu.

"We have absolutely no data showing improvements in survival, tumor shrinkage and/or clinical benefits to patients," said Lu. "Now when patients ask their oncologists about shark cartilage, physicians can point to this large NCI-sponsored Phase III trial and tell patients that, at this point, the only studies that have been done with cartilage-derived products have been negative."

Lung cancer is the leading cancer killer in both men and women; according to the American Cancer Society, approximately 219,440 were diagnosed with lung cancer in 2009 and 159,390 died from the disease.

Non-small cell is the most common type of the disease, accounting for about 80 percent of all lung cancers, said Lu.


'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Related medicine news :

1. Shark Cartilage Not Beneficial in Advanced Lung Cancer
2. Shark Attack Study Announced: Politics of Bite Incidents Under Review
3. NIH study confirms location of stem cells near cartilage-rich regions in bones
4. Nanofiber Gel May Spur Growth of New Knee Cartilage
5. Cartilage repair can improve life, ease burden on health services
6. Gene Therapy Shows Promise for Muscular Dystrophy
7. CA-125 change over time shows promise as screening tool for early detection of ovarian cancer
8. Fat in Males, Females Differs Genetically, Mouse Study Shows
9. Social Media Driving Leads & Sales, New Report Shows
10. Drug in new class of targeted therapies shows early promise against blood-related cancers
11. Varicose vein study shows radiofrequency ablation causes less post-operative pain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/14/2016)... ... February 14, 2016 , ... In honor of ... Nurses (AAHFN) is promoting healthier living with heart failure by providing educational materials ... Living with Heart Failure will kick-off February 14 and includes tips on keeping ...
(Date:2/13/2016)... ... February 13, 2016 , ... Many individuals looking to lead a healthy lifestyle ... reasons. IsoPasta by Isolator Fitness has delved into this niche allowing those giving ... high-carb repercussions. IsoPasta has 30 grams of protein and only 7 grams of ...
(Date:2/13/2016)... ... ... an Au Pair comes all the way around the world to provide child ... are often worried things won’t go well. More often than not, however, they find out ... the Year winner’s all commented how their Au Pairs have become a part of the ...
(Date:2/12/2016)... ... 2016 , ... The law firm of Morrow, Morrow, Ryan & Bassett is ... these scholarships is to encourage applicants to pursue a degree in their field of ... parishes. , “We have available jobs in St. Landry and Evangeline Parishes that ...
(Date:2/12/2016)... ... February 12, 2016 , ... Each year, the American Physical ... in Anaheim, CA at the Anaheim Convention Center. Almost 10,000 physical therapists across the ... products in action, learn more about their chosen field and network with their colleagues. ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... , 12 februari 2016 ... een toonaangevende leverancier van productie en ontwikkeling ... industrieën, kondigt vandaag een uitbreiding aan van ... haar locatie in Charleston, SC ... geleid tot meerdere recente investeringen. ...
(Date:2/12/2016)... , Ungarn, February 12, 2016 ... das sich auf den ungedeckten medizinischen Bedarf ... positive Ergebnisse seines klinischen Forschungsprogramms bekannt. Das ... beschäftigt, ergab Verbesserungen ihrer respiratorischen Funktionen und ... ltd , ein Medizintechnikunternehmen, das sich auf ...
(Date:2/11/2016)... NEW YORK , Feb. 11, 2016 ... - Companion Diagnostics in Personalized Medicine and Cancer ... Markets. - High-Growth Diagnostic Testing Markets. - ... Cancer Testing. - Molecular Diagnostics in Genetic Testing. ... - Molecular Diagnostics Markets. - Over-the-Counter Diagnostic Products ...
Breaking Medicine Technology: