Navigation Links
Shar-Pei Dogs Shed Light on Human Fever Syndromes
Date:3/17/2011

THURSDAY, March 17 (HealthDay News) -- The gene mutation responsible for the wrinkled skin of Shar-Pei dogs is also linked to a periodic fever disorder, a finding that could have important implications for human health, researchers report.

Shar-Pei dogs have a high prevalence of a periodic fever disorder that is similar to inherited autoinflammatory periodic fever syndromes in humans.

The thick, wrinkled skin of Shar-Pei dogs contains an excess of hyaluronan, most likely because of an over-activation of the hyaluronan synthase 2 (HAS2) gene. The fever disorder in the dogs occurs when overproduction of hyaluronan activates the immune system, according to scientists at the Broad Institute in Cambridge, Mass., and Uppsala University in Sweden.

The finding, published in the March 17 online edition of the journal PLoS Genetics, could help improve understanding of human inflammatory diseases, the researchers said. They noted that the genetic cause of periodic fever syndromes in humans is unknown in about 60 percent of cases.

"The finding that hyaluronan is a major trigger of fever opens a new research field in canine and human inflammatory disease," senior author Kerstin Lindblad-Toh said in a journal news release.

More information

The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases has more about autoinflammatory diseases.

-- Robert Preidt

SOURCE: PLoS Genetics, news release, March 17, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Rat Study Sheds Light on How Alcohol Affects Young Brain
2. Self-administered light therapy may improve cognitive function after traumatic brain injury
3. A check engine light for the human body?
4. Mount Sinai researcher finds unexpected temperature sensation for a light detector
5. Brains Learning Ability Seems to Recharge During Light Slumber
6. Research sheds light on fat digestibility in pigs
7. How sunlight may reduce the severity of multiple sclerosis
8. Improved lesion detection with time-of-flight PET scans affirmed
9. CROI -- Day 3: Selected highlights of NIH-supported research
10. Emergency mental health lessons learned from Continental Flight 3407 disaster
11. Spotlight on autism research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Shar-Pei Dogs Shed Light on Human Fever Syndromes
(Date:4/30/2016)... ... April 30, 2016 , ... Saturday, April ... veterinarians’ global impact on public health. The World Veterinary Association (WVA) and the ... year have selected continuing education with a One Health focus, which emphasizes how ...
(Date:4/30/2016)... ... April 30, 2016 , ... Orlando-based Maximized Living has selected Dr. Nick ... in Rio. Under the care of Maximized Living doctors at the London Olympics ... showing, Maximized Living is sending the largest contingent of elite chiropractors to Rio to ...
(Date:4/29/2016)... , ... April 29, 2016 , ... ... Ten Footwear Foundation, the national charitable foundation serving the footwear industry, has broken ... volunteers representing more than 130 companies across 23 states during the months of ...
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... On Tuesday, ... hospitals across the Southeast, celebrated the signature of Gov. Nathan Deal on SB 258, ... Geoff Duncan (R - Cumming), offers a 70% tax credit to individuals and corporations ...
(Date:4/29/2016)... ... April 29, 2016 , ... Conditions were ideal for Global ... Park on Sunday, with sunny skies, a light breeze and temperatures in the 60s. ... , The 5k Run and Walk and 1-mile walk were held to increase ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... April 27, 2016   ... Growth in Recurring Consumable Sales  Clinical sales ... Kea Technologies (Euronext: MKEA, OTCQX: MKEAY) inventor of Cellvizio®, ... sales for the first quarter ended March 31, 2016 ... execution of its commercial strategy. First Quarter ...
(Date:4/27/2016)...  Bayer Animal Health today announced that ... of Florida College of Veterinary Medicine, is the ... Award (BECA). Brittany was selected from entries representing ... of $70,000 in scholarship funds through the 2016 ... provided a total of $232,500 in scholarship awards ...
(Date:4/27/2016)... 2016 The global  gamma ... billion by 2022, according to a new report ... towards a healthy lifestyle is expected to drive ...      (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) , ... health treatment expenditure has urged consumers to switch ...
Breaking Medicine Technology: