Navigation Links
Shar-Pei Dogs Shed Light on Human Fever Syndromes
Date:3/17/2011

THURSDAY, March 17 (HealthDay News) -- The gene mutation responsible for the wrinkled skin of Shar-Pei dogs is also linked to a periodic fever disorder, a finding that could have important implications for human health, researchers report.

Shar-Pei dogs have a high prevalence of a periodic fever disorder that is similar to inherited autoinflammatory periodic fever syndromes in humans.

The thick, wrinkled skin of Shar-Pei dogs contains an excess of hyaluronan, most likely because of an over-activation of the hyaluronan synthase 2 (HAS2) gene. The fever disorder in the dogs occurs when overproduction of hyaluronan activates the immune system, according to scientists at the Broad Institute in Cambridge, Mass., and Uppsala University in Sweden.

The finding, published in the March 17 online edition of the journal PLoS Genetics, could help improve understanding of human inflammatory diseases, the researchers said. They noted that the genetic cause of periodic fever syndromes in humans is unknown in about 60 percent of cases.

"The finding that hyaluronan is a major trigger of fever opens a new research field in canine and human inflammatory disease," senior author Kerstin Lindblad-Toh said in a journal news release.

More information

The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases has more about autoinflammatory diseases.

-- Robert Preidt

SOURCE: PLoS Genetics, news release, March 17, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Rat Study Sheds Light on How Alcohol Affects Young Brain
2. Self-administered light therapy may improve cognitive function after traumatic brain injury
3. A check engine light for the human body?
4. Mount Sinai researcher finds unexpected temperature sensation for a light detector
5. Brains Learning Ability Seems to Recharge During Light Slumber
6. Research sheds light on fat digestibility in pigs
7. How sunlight may reduce the severity of multiple sclerosis
8. Improved lesion detection with time-of-flight PET scans affirmed
9. CROI -- Day 3: Selected highlights of NIH-supported research
10. Emergency mental health lessons learned from Continental Flight 3407 disaster
11. Spotlight on autism research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Shar-Pei Dogs Shed Light on Human Fever Syndromes
(Date:10/13/2017)... ... , ... The Visiting Nurse Association (VNA) of Somerset Hills is proud to ... unique items from across the nation, this holiday-themed event will raise funds and awareness ... VNA. The boutique will be open Saturday, November 4 (10:00 a.m. – 5:00 ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The ... the most popular and least understood books in the Holy Scriptures, Revelation. The Book ... have baffled scholars for centuries. Many have tossed it off as mere rubbish, but ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “The Journey: From ... every danger possible to save lost souls in the Philippines. “The Journey: From the ... is a dedicated teacher of the Bible. She has taught all ages and currently ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and San Francisco dentists, ... cutting-edge Oventus O2Vent technology. As many as 18 million Americans are estimated to ... breathing. Oral appliances can offer significant relief to about 75 percent of people ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( ... today the introduction of an innovative new design of the shoulder pad. The ... get maximum comfort while controlling your pain while using cold therapy. By utilizing ice ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... WASHINGTON , Sept. 28, 2017 Cohen ... to advance the use of wearable and home sensors ... brain disorders. Early Signal Foundation, a nonprofit organization focused ... populations, will provide an affordable analytical system to record ... ...
(Date:9/25/2017)... PROVIDENCE, R.I. , Sept. 25, 2017 /PRNewswire/ ... immunogenicity assessment, vaccine design, and immune-engineering today announced ... focused on the development of personalized therapeutic cancer ... and has provided exclusive access to enabling technologies ... MSc Eng., MBA will lead EpiVax Oncology as ...
(Date:9/19/2017)... Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, ... tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek , PhD, ...
Breaking Medicine Technology: