Navigation Links
Shar-Pei Dogs Shed Light on Human Fever Syndromes
Date:3/17/2011

THURSDAY, March 17 (HealthDay News) -- The gene mutation responsible for the wrinkled skin of Shar-Pei dogs is also linked to a periodic fever disorder, a finding that could have important implications for human health, researchers report.

Shar-Pei dogs have a high prevalence of a periodic fever disorder that is similar to inherited autoinflammatory periodic fever syndromes in humans.

The thick, wrinkled skin of Shar-Pei dogs contains an excess of hyaluronan, most likely because of an over-activation of the hyaluronan synthase 2 (HAS2) gene. The fever disorder in the dogs occurs when overproduction of hyaluronan activates the immune system, according to scientists at the Broad Institute in Cambridge, Mass., and Uppsala University in Sweden.

The finding, published in the March 17 online edition of the journal PLoS Genetics, could help improve understanding of human inflammatory diseases, the researchers said. They noted that the genetic cause of periodic fever syndromes in humans is unknown in about 60 percent of cases.

"The finding that hyaluronan is a major trigger of fever opens a new research field in canine and human inflammatory disease," senior author Kerstin Lindblad-Toh said in a journal news release.

More information

The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases has more about autoinflammatory diseases.

-- Robert Preidt

SOURCE: PLoS Genetics, news release, March 17, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Rat Study Sheds Light on How Alcohol Affects Young Brain
2. Self-administered light therapy may improve cognitive function after traumatic brain injury
3. A check engine light for the human body?
4. Mount Sinai researcher finds unexpected temperature sensation for a light detector
5. Brains Learning Ability Seems to Recharge During Light Slumber
6. Research sheds light on fat digestibility in pigs
7. How sunlight may reduce the severity of multiple sclerosis
8. Improved lesion detection with time-of-flight PET scans affirmed
9. CROI -- Day 3: Selected highlights of NIH-supported research
10. Emergency mental health lessons learned from Continental Flight 3407 disaster
11. Spotlight on autism research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Shar-Pei Dogs Shed Light on Human Fever Syndromes
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can now ... and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings ... The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has dedicated ... has implemented orthobiologic procedures as a method for treating his patients. The procedure ... doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use to ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
(Date:6/24/2016)... ... 24, 2016 , ... Puradigm® & Innovative Solutions today announced ... and processing operations at its production facility, and opened its first two dispensaries ... manufacturer of a complete system of proactive air and surface purification solutions for ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- The Academy of Managed Care Pharmacy (AMCP) today ... allow biopharmaceutical companies to more easily share health care ... coverage decisions, a move that addresses the growing need ... The recommendations address restrictions in the sharing of product ... a prohibition that hinders decision makers from accessing HCEI ...
(Date:6/24/2016)... , June 24, 2016 Research ... World Market for Companion Diagnostic Tests" report to their ... Market for Companion Diagnostics The World Market ... and personalized medicine diagnostics. Market analysis in the report includes ... Test Market (In Vitro Diagnostic Kits) by Region (N. America, ...
(Date:6/24/2016)... Belgium , June 24, 2016 ... today announced the appointment of Dr. Edward ... as a Non-Executive Director, effective June 23, 2016.Dr. ... Compensation and Nominations and Governance Committees.  As a ... will provide independent expertise and strategic counsel to ...
Breaking Medicine Technology: