Navigation Links
'Shapeshifting' computer program will open up drug discovery for tricky disease targets
Date:8/26/2013

ntricate set of mechanisms that regulate many of our critical functions by simply changing protein shape.

"In simple terms, these 'shapeshifter' mechanisms allow the proteins to modulate their biological activity by changing their surface character, rather like tectonic plates moving around the surface of the Earth. The more we understand these mechanisms, the more we can emulate what nature has already developed so elegantly.

"Diseases are often caused by certain molecules in the body being either too active or not active enough or by them operating in the wrong place at the wrong time. The new technology helps discovery of 'shapeshifting' drugs that can carefully adjust these biological molecules, bringing them under control and thus less likely to cause problems.

"We can use this knowledge, in the case of a specific disease, to help a key protein be more or less active when the system is not working optimally on its own."

Strathclyde Professor of Medicinal Chemistry & Drug Discovery Portal Director, Simon Mackay added: "This is an exciting step towards rapidly and efficiently designing the next wave of innovative pharmaceuticals."

Dr John Wilson, of Strathclyde's Department of Computer and Information Sciences, said: "We've been able to understand how to optimise the SID algorithm such that it now provides a near real-time, three-dimensional, graphical output that makes it extremely easy for clients to quickly understand where to focus their efforts."

Serometrix Chief Executive Officer Mike Muehlemann said SID was already yielding promising early leads in the search for potential treatments for hypercholesterolemia high cholesterol and cardiovascular disease. He added: "Drug discovery and development represents one of the toughest technical challenges of our times.

"We have partnered with Strathclyde because their SID technology is best-in-class and fits exceedingly well with our own technology. The promise of better pharmaceuticals
'/>"/>

Contact: Lachlan Mackinnon
lachlan.mackinnon@strath.ac.uk
44-014-154-84123
University of Strathclyde
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New PlantFloorCertification Program from MODULAR Guarantees Operation of Standard Office Computers, Printers, & Displays in Harsh NEMA 4X/IP65 Plant Floor Environments
2. CipherLab Exhibits Its Latest CP60 and 9200 Mobile Computers at RetailNow 2013, Booth# 438, August 6-7, 2013
3. CipherLab CP60 Mobile Computer Chimes in with Prestigious AT&T Certification
4. Monroe, CT Dental Implants Are Now Computer Guided from Dr. Richard Amato for Precise Results
5. Memory improves for older adults using computerized brain-fitness program
6. Iowa VP for Research addresses next-generation supercomputers at congressional hearing
7. NJIT computer scientist publishes new algorithm cluster to data mine health records
8. CipherLab Exhibits Its Latest CP60 Mobile Computers and 1600 Series Barcode Scanners for Courier Industry at MCAA’s Annual Meeting & Exposition, Booth# 10, May 8-10, 2013
9. Computer algorithms help find cancer connections
10. Are Pricey Computer-Aided Mammograms Worth It?
11. Atlanta LASIK Surgeon Interviewed About Computer Vision Syndrome Prevention
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... Perelman School of Medicine at the University of Pennsylvania ... received an $8 million grant from the National Cancer ... therapy (PDT) in patients with malignant pleural mesothelioma, a ... itself in the lining of the lungs and is ... will fund a clinical trial and additional studies looking ...
(Date:7/9/2014)... common type of lung cancer, researchers have uncovered mutations ... forming tumors. The new knowledge may expand treatments for ... already are available or are in clinical trials. , ... The Cancer Genome Atlas (TCGA), including researchers at Washington ... School and other institutions, studied tumors from 230 patients ...
(Date:7/9/2014)... injection drug users in Russia might contribute to ... study, conducted by researchers from Boston University Schools ... St. Petersburg Pavlov State University, sought to discover ... outcomes of a cohort of HIV-positive people with ... were arrested by police were more likely to ...
(Date:7/9/2014)... There has been a sharp increase in the number ... MyChart, the online, interactive service that allows patients to ... providers, schedule appointments, and renew prescriptions. , Over a ... MyChart each year increased five-fold, while the number ... according to a study by Dr. David Gerber ...
(Date:7/9/2014)... It may smell of flatulence and have a reputation for ... dosage, hydrogen sulfide is now being being found to offer ... to stroke, heart attacks and dementia. A new compound (AP39), ... the key to future therapies, by targeting delivery of very ... places inside cells. , Scientists in Exeter have already ...
Breaking Medicine News(10 mins):Health News:Penn mesothelioma program receives $8 million NCI grant 2Health News:Lung cancer study hints at new treatments 2Health News:BU researchers relate arrests with HIV risk environment 2Health News:MyChart use skyrocketing among cancer patients, UT Southwestern study finds 2Health News:MyChart use skyrocketing among cancer patients, UT Southwestern study finds 3Health News:Rotten egg gas holds key to healthcare therapies 2
... Health Partnership - It,s In Our Hands - Has Been ... Caregivers To Healthcare Resources And Services In Local Communities , ... Sanofi-aventis announced the initiation of its Community Health Partnership (CHP), ... seeking to link African American residents with local healthcare professionals ...
... Courage Center,s Transitional,Rehabilitation Program, which is licensed as ... the Stratis Health 2008-2011 Technical Assistance Group, a,learning collaborative ... is,supported by the federal Centers for Medicare & Medicaid ... Medicare Quality Improvement,Organization (QIO). , ...
... Turner as Chairman, Robert Schnitzius as Acting President & CEO ... DelSite, Inc. (OTC Bulletin Board: DSII.OB), a drug delivery technology ... directors for the Company, has resigned his position as chairman, effective ... until his term ends in May 2009. , ...
... Associates in Tropical Health (LATH), a consulting arm of ... 10 million contract to manage a programme of work ... in Malawi. , Led by the National Research ... year programme supported by the Wellcome Trust, the UK ...
... 11 Americans United for Life (AUL) today released ... addition of eight new guides this year, AUL now offers ... abortion, protection of unborn victims of violence, bioethics, healthcare rights ... Dr. Charmaine Yoest, AUL President & CEO said, ...
... this year,s Gottfried Wilhelm Leibniz Prize have been officially ... Committee of the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) ... this year,s winners of Germany,s most prestigious research prize. ... 141 candidates. , The 2009 Gottfried Wilhelm Leibniz Prize ...
Cached Medicine News:Health News:Sanofi-aventis Partners with the African American Community in Baltimore to Increase Health Awareness, Access to Resources and Help Improve Patient Care 2Health News:Sanofi-aventis Partners with the African American Community in Baltimore to Increase Health Awareness, Access to Resources and Help Improve Patient Care 3Health News:Sanofi-aventis Partners with the African American Community in Baltimore to Increase Health Awareness, Access to Resources and Help Improve Patient Care 4Health News:Courage Center Transitional Rehabilitation Program to Participate in Learning Collaborative With Stratis Health 2Health News:DelSite Chairman George DeMott Resigns 2Health News:DelSite Chairman George DeMott Resigns 3Health News:LATH wins contract to boost health research capacity in Malawi 2Health News:Americans United for Life Releases Eight New Model Legislation & Policy Guides: Twenty-Three Model Legislation & Policy Guides Now Available 2Health News:The 2009 Leibniz Prize: Eleven new scientific discoverers 2Health News:The 2009 Leibniz Prize: Eleven new scientific discoverers 3Health News:The 2009 Leibniz Prize: Eleven new scientific discoverers 4Health News:The 2009 Leibniz Prize: Eleven new scientific discoverers 5Health News:The 2009 Leibniz Prize: Eleven new scientific discoverers 6Health News:The 2009 Leibniz Prize: Eleven new scientific discoverers 7Health News:The 2009 Leibniz Prize: Eleven new scientific discoverers 8Health News:The 2009 Leibniz Prize: Eleven new scientific discoverers 9Health News:The 2009 Leibniz Prize: Eleven new scientific discoverers 10Health News:The 2009 Leibniz Prize: Eleven new scientific discoverers 11Health News:The 2009 Leibniz Prize: Eleven new scientific discoverers 12
(Date:1/15/2014)... 2014  A novel wearable injector slightly larger than an Oreo ... to self-inject prescription drugs in the large doses required to ... autoimmune deficiencies, and genetic disorders.  An emerging ... 2018, according to analysts.   Many of these drugs will require ...
(Date:1/14/2014)... N.J. , Jan. 14, 2014 InformEx, ... and sellers of high-value chemistry, will hold the 30 th ... Miami Beach Convention Center from January 21-24. ... 3,500 attendees from top pharmaceutical, fine chemical and specialty chemical ...
(Date:1/14/2014)... 2014 /PRNewswire-iReach/ -- Acumed,s new SLIC Screw System - ... instrumentation to place and insert the screw accurately - ... (e.g. ligament) repair or reconstruction as it holds the ... (Photo: http://photos.prnewswire.com/prnh/20140114/MN45636 ) The SLIC ...
Breaking Medicine Technology:Enable Injections Presents A New Class of Injectors for Drug Delivery at PEPTalk, Drug Delivery Partnership Meetings 2Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: