Navigation Links
'Shapeshifting' computer program will open up drug discovery for tricky disease targets
Date:8/26/2013

A unique computer technology that opens up the discovery of smarter drugs to treat major illnesses including heart disease has been invented by University of Strathclyde scientists.

The Shapeshifting Inspired Discovery (SID) program decodes the structures of proteins in our cells that scientists suspect may hold the key to new treatments. The program can rapidly analyse the complicated shapes and identify how the proteins might be "shapeshifted" by drugs.

Shapeshifting involves an altogether different and more subtle mechanism than conventional drugs, which stop the proteins working completely. The team behind SID developed entirely at Strathclyde over the last decade, and now being deployed exclusively in collaboration with US firm Serometrix will apply it to drug discovery for a wide range of diseases and conditions.

Dr Mark Dufton, of Strathclyde's Department of Pure and Applied Chemistry, said: "Conventional drug discovery is extremely expensive, time consuming and often heavily reliant on 'lottery techniques' to identify useful drugs by chance.

"While this has certainly reaped benefits before, these traditional methods are becoming less fruitful and many new drug candidates found in this way are being abandoned because of toxicity problems and side effects. Drugs that act by shapeshifting work in a much smarter way that is a closer mimic of natural mechanisms for control.

"The ability of SID to predict the scope for 'shapeshifting' enables us to probe large, complex biological molecules which have evolved their intricate shapes over hundreds of millions of years so that we can analyse where and whether they can be targeted to provide treatments. When targeting is more selective, and the mechanism is smarter, a new generation of better medicines beckons.

"There are thousands of different types of protein in the human system that cooperate and regulate each other so that we can function properly. Nature has evolved a beautifully i
'/>"/>

Contact: Lachlan Mackinnon
lachlan.mackinnon@strath.ac.uk
44-014-154-84123
University of Strathclyde
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New PlantFloorCertification Program from MODULAR Guarantees Operation of Standard Office Computers, Printers, & Displays in Harsh NEMA 4X/IP65 Plant Floor Environments
2. CipherLab Exhibits Its Latest CP60 and 9200 Mobile Computers at RetailNow 2013, Booth# 438, August 6-7, 2013
3. CipherLab CP60 Mobile Computer Chimes in with Prestigious AT&T Certification
4. Monroe, CT Dental Implants Are Now Computer Guided from Dr. Richard Amato for Precise Results
5. Memory improves for older adults using computerized brain-fitness program
6. Iowa VP for Research addresses next-generation supercomputers at congressional hearing
7. NJIT computer scientist publishes new algorithm cluster to data mine health records
8. CipherLab Exhibits Its Latest CP60 Mobile Computers and 1600 Series Barcode Scanners for Courier Industry at MCAA’s Annual Meeting & Exposition, Booth# 10, May 8-10, 2013
9. Computer algorithms help find cancer connections
10. Are Pricey Computer-Aided Mammograms Worth It?
11. Atlanta LASIK Surgeon Interviewed About Computer Vision Syndrome Prevention
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... September 16, 2014 Today, Top 10 ... the most recommended suppliers for the webmasters for people ... save money at the same time. , As an ... ) has been offering useful products at low prices ... connected to multiple GB connections to ensure that there ...
(Date:9/16/2014)... (PRWEB) September 16, 2014 Recently, the ... compared a lot of SEO hosting suppliers and announced ... most recommended suppliers for webmasters from the USA, UK, ... products (including VPS and cloud hosting) without spending a ... easy to use shared SEO hosting plans come with ...
(Date:9/16/2014)... (PRWEB) September 16, 2014 Care ... Logistics™, a component of the Hospital Operating System™ ... match patient needs with staff capacity. For the ... understanding of actual nursing and other staff capacity. ... of patient-care needs, anticipated admissions, discharges and transfers, ...
(Date:9/16/2014)... Randy Dotinga HealthDay Reporter , ... pattern baldness may face a higher risk of developing an ... a new study suggests. But, the study authors noted ... pattern of baldness should be concerned. Their study only found ... It did not prove cause and effect. "It is ...
(Date:9/16/2014)... September 15, 2014 Combining a standard chemotherapy ... from dividing improves both the survival and response ... new study by UT Southwestern Medical Center cancer ... the chemotherapy drug cisplatin with pemetrexed - an ... showed promising results for advanced, persistent, or recurrent ...
Breaking Medicine News(10 mins):Health News:Top 10 Best SEO Hosting: These Companies Are The Best Cheap SEO Hosting Suppliers In 2014 2Health News:Great SEO Hosting Suppliers Announced By Top 10 Best SEO Hosting 2Health News:Care Logistics Launches Demand Logistics as Part of the Hospital Operating System 2Health News:Male Pattern Baldness Tied to Prostate Cancer, Study Suggests 2Health News:Male Pattern Baldness Tied to Prostate Cancer, Study Suggests 3Health News:Cancer-fighting cocktail demonstrates promising results as treatment for advanced cervical cancer 2
... different types of dementia, but these findings are shocking. We ... study", say researchers Elisabet Englund and Hans Brunnstrm at Lund ... from the cities of Lund and Malm. All of them ... period 1996-2006 and been diagnosed with some form of dementia. ...
... Boston and Google.org have found web-based search data to be ... of outbreaks of dengue, an emerging mosquito-borne virus found in ... capture of disease-related queries in near real time, it could ... affected by dengue respond more quickly to nascent epidemics. ...
... new test that identifies the specific type of tumour they ... at the University of Edinburgh hope this improved diagnosis will ... the most effective drugs. The Edinburgh team worked with ... each of which had a different genetic signature. ...
... Private health clinics across Canada providing weight-loss surgeries are ... and at the expense of quality patient care, according to ... Chaim Bell. "The private clinics in Canada offer ... banding the upper stomach to restrict food intake to patients ...
... Randy Dotinga HealthDay Reporter , MONDAY, May 30 ... are marketed heavily toward children and teens, a leading association ... kids. Young children and teens should avoid energy drinks ... issued Monday, and routine consumption of sports drinks should be ...
... Ill. Functional magnetic resonance imaging (fMRI) may provide ... researchers at Columbia University in New York City, who ... children. Results of their study appear online and in ... is a spectrum disorder characterized by repetitive behaviors and ...
Cached Medicine News:Health News:Difficulties in diagnosing dementia type 2Health News:Searching the web for dengue 2Health News:Targeted testing offers treatment hope for ovarian cancer patients 2Health News:Private weight-loss surgery clinics shedding quality patient care 2Health News:Pediatricians Group Raps Energy and Sports Drinks for Kids 2Health News:Pediatricians Group Raps Energy and Sports Drinks for Kids 3Health News:New research may lead to improved diagnosis of autism 2
(Date:9/16/2014)... Ind. , Sept. 16, 2014   Evana ... of custom, automated assembly and test systems, recently received ... a leading medical device manufacturer. The Evana solution will ... quality and ergonomics, as well as reduce labor. ... automatically fed to Evana,s robotic assembly cell. The robot ...
(Date:9/16/2014)... , Sept. 16, 2014   Vestagen Technical Textiles, ... patient experience at hospitals. The myComfort™ line of patient ... barrier fabric that is fluid repellant, breathable and in ... the growth of bacteria on the fabric i . ... plays in the chain of transmission. We want myComfort ...
(Date:9/16/2014)... , Sept. 16, 2014  Synereca Pharmaceutics, ... novel orally active drugs that restore or ... today a $1.4 million convertible debt financing. ... life sciences accelerator Accele Biopharma, Inc., led ... a nationally recognized private not-for-profit corporation focused ...
Breaking Medicine Technology:Evana Automation to Supply Robotic Assembly Cell to Leading Medical Device Manufacturer 2Evana Automation to Supply Robotic Assembly Cell to Leading Medical Device Manufacturer 3New Vestagen Patient Garments Aim to Minimize Pathogen Transmission Inside Hospitals 2Synereca Pharmaceuticals Announces Financing Led by Accele Venture Partners 2Synereca Pharmaceuticals Announces Financing Led by Accele Venture Partners 3Synereca Pharmaceuticals Announces Financing Led by Accele Venture Partners 4
... 1, 2011 Deb Group today announced the ... the world,s first group monitoring system to report ... new innovation, hospitals can now immediately monitor compliance ... "Five Moments for Hand Hygiene." A stand-alone system, ...
... Echo Therapeutics, Inc. (OTC Bulletin Board: ... tCGM System as a non-invasive, wireless, transdermal continuous ... System for transdermal drug delivery, today announced that ... & Sullivan Technology Innovation Award in Pharmaceuticals and ...
Cached Medicine Technology:Deb Group Introduces First Real-time Hand Hygiene Group Monitoring System Based on World Health Organization Guidelines 2Deb Group Introduces First Real-time Hand Hygiene Group Monitoring System Based on World Health Organization Guidelines 3Echo Therapeutics Receives Frost & Sullivan's 2011 Technology Innovation Award 2Echo Therapeutics Receives Frost & Sullivan's 2011 Technology Innovation Award 3Echo Therapeutics Receives Frost & Sullivan's 2011 Technology Innovation Award 4
... Self-Cath Closed System is a latex-free ... for safe, simple catheterization designed to ... infections. It includes a 100% ... new EasyOff tear tab makes it ...
The latex free, hydrophilic Self-Cath Plus is designed for single use, intermittent self-catheterization. The unique hydrophilic coating activates immediately upon exposure to water for fast, clean...
... Closed System is a latex-free unisex ... safe, simple catheterization designed to reduce ... It includes a 100% latex-free ... EasyOff tear tab makes it easy ...
... System is a latex-free unisex system ... simple catheterization designed to reduce the ... It includes a 100% latex-free Mentor ... tear tab makes it easy to ...
Medicine Products: